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[Effects of piracetam on pain sensitivity and levels of beta-endorphin in blood and cAMP in the cerebral cortex of rats].
Biull Eksp Biol Med. 1990 Feb; 109(2):163-5.BE

Abstract

It has been shown, that piracetam by i.p. injection (10, 100, 400 mg/kg) or by consumption with drinking water 10, 100, 1000 mg/kg/day during 12 days delays extinction of conditioned reflex of passive avoidance and dose-dependence elevates exploratory activity in "open field", pain sensitivity threshold reduces to 70-75%. Prolonged consumption of 1000 mg/kg/day piracetam results in 3-fold decrease of beta-endorphin concentration in plasma (p less than 0.01) and 100 mg/kg/day--in 35% increase of cAMP content in rat brain cortex.

Authors

Vakulina OP
No affiliation info available
Iasnetsov VV
No affiliation info available
Isachenkov VA
No affiliation info available
Krylova IN
No affiliation info available
Tishkova IP
No affiliation info available
Bragin EO
No affiliation info available
Popkova EV
No affiliation info available

MeSH

AnimalsAvoidance LearningCerebral CortexConditioning, ClassicalCyclic AMPExploratory BehaviorInjections, IntraperitonealMalePain MeasurementPiracetamPyrrolidinonesRatsRats, Inbred StrainsTime Factorsbeta-Endorphin

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

2159815

Citation

Vakulina, O P., et al. "[Effects of Piracetam On Pain Sensitivity and Levels of Beta-endorphin in Blood and cAMP in the Cerebral Cortex of Rats]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 109, no. 2, 1990, pp. 163-5.
Vakulina OP, Iasnetsov VV, Isachenkov VA, et al. [Effects of piracetam on pain sensitivity and levels of beta-endorphin in blood and cAMP in the cerebral cortex of rats]. Biull Eksp Biol Med. 1990;109(2):163-5.
Vakulina, O. P., Iasnetsov, V. V., Isachenkov, V. A., Krylova, I. N., Tishkova, I. P., Bragin, E. O., & Popkova, E. V. (1990). [Effects of piracetam on pain sensitivity and levels of beta-endorphin in blood and cAMP in the cerebral cortex of rats]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 109(2), 163-5.
Vakulina OP, et al. [Effects of Piracetam On Pain Sensitivity and Levels of Beta-endorphin in Blood and cAMP in the Cerebral Cortex of Rats]. Biull Eksp Biol Med. 1990;109(2):163-5. PubMed PMID: 2159815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of piracetam on pain sensitivity and levels of beta-endorphin in blood and cAMP in the cerebral cortex of rats]. AU - Vakulina,O P, AU - Iasnetsov,V V, AU - Isachenkov,V A, AU - Krylova,I N, AU - Tishkova,I P, AU - Bragin,E O, AU - Popkova,E V, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - 163 EP - 5 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 109 IS - 2 N2 - It has been shown, that piracetam by i.p. injection (10, 100, 400 mg/kg) or by consumption with drinking water 10, 100, 1000 mg/kg/day during 12 days delays extinction of conditioned reflex of passive avoidance and dose-dependence elevates exploratory activity in "open field", pain sensitivity threshold reduces to 70-75%. Prolonged consumption of 1000 mg/kg/day piracetam results in 3-fold decrease of beta-endorphin concentration in plasma (p less than 0.01) and 100 mg/kg/day--in 35% increase of cAMP content in rat brain cortex. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/2159815/[Effects_of_piracetam_on_pain_sensitivity_and_levels_of_beta_endorphin_in_blood_and_cAMP_in_the_cerebral_cortex_of_rats]_ DB - PRIME DP - Unbound Medicine ER -