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Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose.
Am J Chin Med. 2011; 39(3):551-63.AJ

Abstract

This study attempted to access the neuroprotective effect of diosgenin on the senescent mice induced by d-galactose (D-gal). The mice in the experiments were orally administered with diosgenin (1, 5, 25 and 125 mg/kg), for four weeks from the sixth week. The learning and memory abilities of the mice in Morris water maze test and the mechanism involved in the neuroprotective effect of diosgenin on the mice brain tissue were investigated. Diosgenin (5, 25 and 125 mg/kg, p.o.) showed significantly improved learning and memory abilities in Morris water maze test compared to D-gal treated mice (200 mg/kg, ten weeks). Diosgenin also increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and decreased the malondialdehyde (MDA) level in the brain of D-gal treated mice. These results indicated that diosgenin has the potential to be a useful treatment for cognitive impairment. In addition, the memory enhancing effect of diosgenin may be partly mediated via enhancing endogenous antioxidant enzymatic activities.

Authors+Show Affiliations

School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21598421

Citation

Chiu, Chuan-Sung, et al. "Diosgenin Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced By D-galactose." The American Journal of Chinese Medicine, vol. 39, no. 3, 2011, pp. 551-63.
Chiu CS, Chiu YJ, Wu LY, et al. Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose. Am J Chin Med. 2011;39(3):551-63.
Chiu, C. S., Chiu, Y. J., Wu, L. Y., Lu, T. C., Huang, T. H., Hsieh, M. T., Lu, C. Y., & Peng, W. H. (2011). Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose. The American Journal of Chinese Medicine, 39(3), 551-63.
Chiu CS, et al. Diosgenin Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced By D-galactose. Am J Chin Med. 2011;39(3):551-63. PubMed PMID: 21598421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose. AU - Chiu,Chuan-Sung, AU - Chiu,Yung-Jia, AU - Wu,Lung-Yuan, AU - Lu,Tsung-Chun, AU - Huang,Tai-Hung, AU - Hsieh,Ming-Tsuen, AU - Lu,Chung-Yen, AU - Peng,Wen-Huang, PY - 2011/5/21/entrez PY - 2011/5/21/pubmed PY - 2011/12/13/medline SP - 551 EP - 63 JF - The American journal of Chinese medicine JO - Am J Chin Med VL - 39 IS - 3 N2 - This study attempted to access the neuroprotective effect of diosgenin on the senescent mice induced by d-galactose (D-gal). The mice in the experiments were orally administered with diosgenin (1, 5, 25 and 125 mg/kg), for four weeks from the sixth week. The learning and memory abilities of the mice in Morris water maze test and the mechanism involved in the neuroprotective effect of diosgenin on the mice brain tissue were investigated. Diosgenin (5, 25 and 125 mg/kg, p.o.) showed significantly improved learning and memory abilities in Morris water maze test compared to D-gal treated mice (200 mg/kg, ten weeks). Diosgenin also increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and decreased the malondialdehyde (MDA) level in the brain of D-gal treated mice. These results indicated that diosgenin has the potential to be a useful treatment for cognitive impairment. In addition, the memory enhancing effect of diosgenin may be partly mediated via enhancing endogenous antioxidant enzymatic activities. SN - 1793-6853 UR - https://www.unboundmedicine.com/medline/citation/21598421/Diosgenin_ameliorates_cognition_deficit_and_attenuates_oxidative_damage_in_senescent_mice_induced_by_D_galactose_ L2 - https://www.worldscientific.com/doi/10.1142/S0192415X11009020?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -