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Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats.
Pharm Biol. 2011 Jul; 49(7):696-701.PB

Abstract

CONTEXT

Oxidative stress plays a key role in pathophysiology of many neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and so on. Although Matricaria recutita L. (Asteraceae), German chamomile, is traditionally used for central nervous system (CNS)-related diseases, its antistress properties have received little attention.

OBJECTIVE

The present study evaluated the neuroprotective effect of German chamomile against aluminium fluoride (AlF₄⁻)-induced oxidative stress in rats.

MATERIALS AND METHODS

The Sprague-Dawley rats of either sex (200-250 g) were selected and grouped as: group I received normal saline; group II received AlF₄⁻ (negative control); groups III, IV, and V received 100, 200, and 300 mg/kg, orally, German chamomile methanol extract (GCME) along with AlF₄⁻; and group VI received quercetin (25 mg/kg, i.p.) + AlF₄⁻, respectively. After 10 days treatment with GCME, oxidative stress was induced by administering AlF₄⁻ through drinking water for 7 days. Then, the protective antioxidant enzyme levels were measured and the histopathological studies were carried out.

RESULTS

The GCME showed dose-dependent neuroprotective activity by significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and total thiol levels in extract-treated animals as compared with negative control group (P < 0.001). The histopathological studies also revealed the potent neuroprotective action of German chamomile against oxidative brain damage.

CONCLUSION

The present study for the first time shows potent neuroprotective activity of the methanol extract of German chamomile against AlF₄⁻-induced oxidative stress in rats.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Saurashtra University, Rajkot-360005, Gujarat, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21599496

Citation

Ranpariya, V L., et al. "Neuroprotective Activity of Matricaria Recutita Against Fluoride-induced Stress in Rats." Pharmaceutical Biology, vol. 49, no. 7, 2011, pp. 696-701.
Ranpariya VL, Parmar SK, Sheth NR, et al. Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats. Pharm Biol. 2011;49(7):696-701.
Ranpariya, V. L., Parmar, S. K., Sheth, N. R., & Chandrashekhar, V. M. (2011). Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats. Pharmaceutical Biology, 49(7), 696-701. https://doi.org/10.3109/13880209.2010.540249
Ranpariya VL, et al. Neuroprotective Activity of Matricaria Recutita Against Fluoride-induced Stress in Rats. Pharm Biol. 2011;49(7):696-701. PubMed PMID: 21599496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats. AU - Ranpariya,V L, AU - Parmar,S K, AU - Sheth,N R, AU - Chandrashekhar,V M, Y1 - 2011/05/20/ PY - 2011/5/24/entrez PY - 2011/5/24/pubmed PY - 2011/10/1/medline SP - 696 EP - 701 JF - Pharmaceutical biology JO - Pharm Biol VL - 49 IS - 7 N2 - CONTEXT: Oxidative stress plays a key role in pathophysiology of many neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and so on. Although Matricaria recutita L. (Asteraceae), German chamomile, is traditionally used for central nervous system (CNS)-related diseases, its antistress properties have received little attention. OBJECTIVE: The present study evaluated the neuroprotective effect of German chamomile against aluminium fluoride (AlF₄⁻)-induced oxidative stress in rats. MATERIALS AND METHODS: The Sprague-Dawley rats of either sex (200-250 g) were selected and grouped as: group I received normal saline; group II received AlF₄⁻ (negative control); groups III, IV, and V received 100, 200, and 300 mg/kg, orally, German chamomile methanol extract (GCME) along with AlF₄⁻; and group VI received quercetin (25 mg/kg, i.p.) + AlF₄⁻, respectively. After 10 days treatment with GCME, oxidative stress was induced by administering AlF₄⁻ through drinking water for 7 days. Then, the protective antioxidant enzyme levels were measured and the histopathological studies were carried out. RESULTS: The GCME showed dose-dependent neuroprotective activity by significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and total thiol levels in extract-treated animals as compared with negative control group (P < 0.001). The histopathological studies also revealed the potent neuroprotective action of German chamomile against oxidative brain damage. CONCLUSION: The present study for the first time shows potent neuroprotective activity of the methanol extract of German chamomile against AlF₄⁻-induced oxidative stress in rats. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/21599496/Neuroprotective_activity_of_Matricaria_recutita_against_fluoride_induced_stress_in_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2010.540249 DB - PRIME DP - Unbound Medicine ER -