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Toll-like receptors, inflammation, metabolism and obesity.
Arch Physiol Biochem. 2011 Jul; 117(3):151-64.AP

Abstract

Obesity is a highly prevalent health problem in Western countries that leads to many important diseases such as type 2 diabetes and metabolic syndrome being now considered an inflammatory chronic disease. Adipocytes are no longer considered passive cells storing fat since they are major producers of inflammatory cytokines during obesity. Adipocytes and macrophages share many biological properties including the synthesis of similar molecules regulating inflammation. Fatty acid levels are elevated in obesity and induce inflammatory pathways by yet a mostly unknown mechanism, leading to the development of insulin and leptin resistance. Recent studies suggest that these effects could be mediated through the activation of toll-like receptors (TLR). TLR signalling pathways might contribute to the development of obesity-associated insulin resistance, thus representing a connection between innate immunity and metabolism. Here, we summarize the recent evidence for the important role that TLRs play in adipose tissue, obesity and insulin resistance.

Authors+Show Affiliations

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. mfresno@cbm.uam.esNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21599616

Citation

Fresno, Manuel, et al. "Toll-like Receptors, Inflammation, Metabolism and Obesity." Archives of Physiology and Biochemistry, vol. 117, no. 3, 2011, pp. 151-64.
Fresno M, Alvarez R, Cuesta N. Toll-like receptors, inflammation, metabolism and obesity. Arch Physiol Biochem. 2011;117(3):151-64.
Fresno, M., Alvarez, R., & Cuesta, N. (2011). Toll-like receptors, inflammation, metabolism and obesity. Archives of Physiology and Biochemistry, 117(3), 151-64. https://doi.org/10.3109/13813455.2011.562514
Fresno M, Alvarez R, Cuesta N. Toll-like Receptors, Inflammation, Metabolism and Obesity. Arch Physiol Biochem. 2011;117(3):151-64. PubMed PMID: 21599616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toll-like receptors, inflammation, metabolism and obesity. AU - Fresno,Manuel, AU - Alvarez,Ruth, AU - Cuesta,Natalia, Y1 - 2011/05/23/ PY - 2011/5/24/entrez PY - 2011/5/24/pubmed PY - 2011/10/1/medline SP - 151 EP - 64 JF - Archives of physiology and biochemistry JO - Arch Physiol Biochem VL - 117 IS - 3 N2 - Obesity is a highly prevalent health problem in Western countries that leads to many important diseases such as type 2 diabetes and metabolic syndrome being now considered an inflammatory chronic disease. Adipocytes are no longer considered passive cells storing fat since they are major producers of inflammatory cytokines during obesity. Adipocytes and macrophages share many biological properties including the synthesis of similar molecules regulating inflammation. Fatty acid levels are elevated in obesity and induce inflammatory pathways by yet a mostly unknown mechanism, leading to the development of insulin and leptin resistance. Recent studies suggest that these effects could be mediated through the activation of toll-like receptors (TLR). TLR signalling pathways might contribute to the development of obesity-associated insulin resistance, thus representing a connection between innate immunity and metabolism. Here, we summarize the recent evidence for the important role that TLRs play in adipose tissue, obesity and insulin resistance. SN - 1744-4160 UR - https://www.unboundmedicine.com/medline/citation/21599616/Toll_like_receptors_inflammation_metabolism_and_obesity_ L2 - https://www.tandfonline.com/doi/full/10.3109/13813455.2011.562514 DB - PRIME DP - Unbound Medicine ER -