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Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice.
Food Chem Toxicol. 2011 Sep; 49(9):1943-7.FC

Abstract

Flavonoids are widely found in plants and many of them possess biological and pharmacological activities. In the present study, we assessed the effects of the flavonoids Genistein, Apigenin, Quercetin, Rutin and Astilbin on xanthine oxidase (XO) activities in vitro, and in serum and the liver. The effects of the flavonoids on serum uric acid levels were also measured in vivo. In vitro studies indicated that the flavonoids tested did not significantly affect XO activity. However, significant increases and decreases in XO activities were observed in vivo. Moreover, serum XO activity was correlated with serum uric acid levels, while no correlation was observed for liver XO activity. The present study showed that serum uric acid levels in mice treated with the flavonoids tested here are higher than control levels. Therefore, the flavonoids tested here are not candidates for replacing Allopurinol as a treatment to reduce serum uric acid levels.

Authors+Show Affiliations

Department of Physiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21600261

Citation

Huang, Jingqun, et al. "Effects of Genistein, Apigenin, Quercetin, Rutin and Astilbin On Serum Uric Acid Levels and Xanthine Oxidase Activities in Normal and Hyperuricemic Mice." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 49, no. 9, 2011, pp. 1943-7.
Huang J, Wang S, Zhu M, et al. Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice. Food Chem Toxicol. 2011;49(9):1943-7.
Huang, J., Wang, S., Zhu, M., Chen, J., & Zhu, X. (2011). Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 49(9), 1943-7. https://doi.org/10.1016/j.fct.2011.04.029
Huang J, et al. Effects of Genistein, Apigenin, Quercetin, Rutin and Astilbin On Serum Uric Acid Levels and Xanthine Oxidase Activities in Normal and Hyperuricemic Mice. Food Chem Toxicol. 2011;49(9):1943-7. PubMed PMID: 21600261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice. AU - Huang,Jingqun, AU - Wang,Siwang, AU - Zhu,Miaozhang, AU - Chen,Jianzong, AU - Zhu,Xiaoxing, Y1 - 2011/05/10/ PY - 2011/01/17/received PY - 2011/04/20/revised PY - 2011/04/23/accepted PY - 2011/5/24/entrez PY - 2011/5/24/pubmed PY - 2011/12/13/medline SP - 1943 EP - 7 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 49 IS - 9 N2 - Flavonoids are widely found in plants and many of them possess biological and pharmacological activities. In the present study, we assessed the effects of the flavonoids Genistein, Apigenin, Quercetin, Rutin and Astilbin on xanthine oxidase (XO) activities in vitro, and in serum and the liver. The effects of the flavonoids on serum uric acid levels were also measured in vivo. In vitro studies indicated that the flavonoids tested did not significantly affect XO activity. However, significant increases and decreases in XO activities were observed in vivo. Moreover, serum XO activity was correlated with serum uric acid levels, while no correlation was observed for liver XO activity. The present study showed that serum uric acid levels in mice treated with the flavonoids tested here are higher than control levels. Therefore, the flavonoids tested here are not candidates for replacing Allopurinol as a treatment to reduce serum uric acid levels. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/21600261/Effects_of_genistein_apigenin_quercetin_rutin_and_astilbin_on_serum_uric_acid_levels_and_xanthine_oxidase_activities_in_normal_and_hyperuricemic_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(11)00177-3 DB - PRIME DP - Unbound Medicine ER -