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Fusion image-based programming after subthalamic nucleus deep brain stimulation.
World Neurosurg. 2011 Mar-Apr; 75(3-4):517-24.WN

Abstract

OBJECTIVE

To propose fusion image-based programming to adjust patients with advanced Parkinson disease (PD) effectively after subthalamic nucleus (STN) deep brain stimulation (DBS).

METHODS

Between January 2007 and July 2008, 38 patients with advanced PD were consecutively treated with STN DBS. The electrode positions and information regarding their contacts with STN were determined via fusion of the images of preoperative magnetic resonance imaging (MRI) and of postoperative computed tomography (CT) obtained 1 month after STN DBS. Postoperative programming was performed using the information of electrode positions based on the fused images. All patients were evaluated with a prospective protocol of the Unified Parkinson Disease Rating Scale (UPDRS), Hoehn and Yahr Staging, Schwab and England Activities of Daily Living (SEADL), levodopa equivalent daily dose (LEDD), short-form-36 health survey (SF-36), and neuropsychological tests before and at 3 months and 6 months after surgery.

RESULTS

There was a rapid and significant improvement of motor symptoms, especially tremor and rigidity, after STN stimulation, with low morbidity. Stimulation led to an improvement in the off-medication UPDSR III scores of the patients of approximately 55% at 3 months and 6 months after STN DBS. Dyskinesia was significantly improved (74% at 3 months and 95% at 6 months) after STN DBS. In addition, LEDD values decreased to 50% of the level observed before surgery within 1 month after STN DBS.

CONCLUSIONS

Programming based on fused images of preoperative MRI and postoperative CT after STN DBS was performed quickly, easily, and efficiently.

Authors+Show Affiliations

Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21600506

Citation

Paek, Sun Ha, et al. "Fusion Image-based Programming After Subthalamic Nucleus Deep Brain Stimulation." World Neurosurgery, vol. 75, no. 3-4, 2011, pp. 517-24.
Paek SH, Kim HJ, Yoon JY, et al. Fusion image-based programming after subthalamic nucleus deep brain stimulation. World Neurosurg. 2011;75(3-4):517-24.
Paek, S. H., Kim, H. J., Yoon, J. Y., Heo, J. H., Kim, C., Kim, M. R., Lim, Y. H., Kim, K. R., Kim, J. W., Han, J. H., Kim, D. G., & Jeon, B. S. (2011). Fusion image-based programming after subthalamic nucleus deep brain stimulation. World Neurosurgery, 75(3-4), 517-24. https://doi.org/10.1016/j.wneu.2010.12.003
Paek SH, et al. Fusion Image-based Programming After Subthalamic Nucleus Deep Brain Stimulation. World Neurosurg. 2011 Mar-Apr;75(3-4):517-24. PubMed PMID: 21600506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fusion image-based programming after subthalamic nucleus deep brain stimulation. AU - Paek,Sun Ha, AU - Kim,Hee Jin, AU - Yoon,Ji Young, AU - Heo,Jae Heok, AU - Kim,Cheolyoung, AU - Kim,Mi Ryoung, AU - Lim,Yong Hoon, AU - Kim,Keyong Ran, AU - Kim,Jin Wook, AU - Han,Jung Ho, AU - Kim,Dong Gyu, AU - Jeon,Beom S, PY - 2010/02/16/received PY - 2010/10/03/revised PY - 2010/12/01/accepted PY - 2011/5/24/entrez PY - 2011/5/24/pubmed PY - 2011/7/26/medline SP - 517 EP - 24 JF - World neurosurgery JO - World Neurosurg VL - 75 IS - 3-4 N2 - OBJECTIVE: To propose fusion image-based programming to adjust patients with advanced Parkinson disease (PD) effectively after subthalamic nucleus (STN) deep brain stimulation (DBS). METHODS: Between January 2007 and July 2008, 38 patients with advanced PD were consecutively treated with STN DBS. The electrode positions and information regarding their contacts with STN were determined via fusion of the images of preoperative magnetic resonance imaging (MRI) and of postoperative computed tomography (CT) obtained 1 month after STN DBS. Postoperative programming was performed using the information of electrode positions based on the fused images. All patients were evaluated with a prospective protocol of the Unified Parkinson Disease Rating Scale (UPDRS), Hoehn and Yahr Staging, Schwab and England Activities of Daily Living (SEADL), levodopa equivalent daily dose (LEDD), short-form-36 health survey (SF-36), and neuropsychological tests before and at 3 months and 6 months after surgery. RESULTS: There was a rapid and significant improvement of motor symptoms, especially tremor and rigidity, after STN stimulation, with low morbidity. Stimulation led to an improvement in the off-medication UPDSR III scores of the patients of approximately 55% at 3 months and 6 months after STN DBS. Dyskinesia was significantly improved (74% at 3 months and 95% at 6 months) after STN DBS. In addition, LEDD values decreased to 50% of the level observed before surgery within 1 month after STN DBS. CONCLUSIONS: Programming based on fused images of preoperative MRI and postoperative CT after STN DBS was performed quickly, easily, and efficiently. SN - 1878-8769 UR - https://www.unboundmedicine.com/medline/citation/21600506/Fusion_image_based_programming_after_subthalamic_nucleus_deep_brain_stimulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1878-8750(10)01002-8 DB - PRIME DP - Unbound Medicine ER -