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The molecular epidemiology of hepatitis E virus infection.
Virus Res. 2011 Oct; 161(1):31-9.VR

Abstract

Molecular characterization of various hepatitis E virus (HEV) strains circulating among humans and animals (particularly swine, deer and boars) in different countries has revealed substantial genetic heterogeneity. The distinctive four-genotype distribution worldwide of mammalian HEV and varying degrees of genetic relatedness among local strains suggest a long and complex evolution of HEV in different geographic regions. The population expansion likely experienced by mammalian HEV in the second half of the 20th century is consistent with an extensive genetic divergence of HEV strains and high prevalence of HEV infections in many parts of the world, including developed countries. The rate and mechanisms of human-to-human transmission and zoonotic transmission to humans vary geographically, thus contributing to the complexity of HEV molecular evolution.

Authors+Show Affiliations

Centers for Disease Control and Prevention, National Center for HIV/Hepatitis/STD/TB Prevention, Division of Viral Hepatitis, Atlanta, GA 30333, USA. mup3@cdc.govNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21600939

Citation

Purdy, Michael A., and Yury E. Khudyakov. "The Molecular Epidemiology of Hepatitis E Virus Infection." Virus Research, vol. 161, no. 1, 2011, pp. 31-9.
Purdy MA, Khudyakov YE. The molecular epidemiology of hepatitis E virus infection. Virus Res. 2011;161(1):31-9.
Purdy, M. A., & Khudyakov, Y. E. (2011). The molecular epidemiology of hepatitis E virus infection. Virus Research, 161(1), 31-9. https://doi.org/10.1016/j.virusres.2011.04.030
Purdy MA, Khudyakov YE. The Molecular Epidemiology of Hepatitis E Virus Infection. Virus Res. 2011;161(1):31-9. PubMed PMID: 21600939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The molecular epidemiology of hepatitis E virus infection. AU - Purdy,Michael A, AU - Khudyakov,Yury E, Y1 - 2011/05/11/ PY - 2011/01/27/received PY - 2011/03/23/revised PY - 2011/04/29/accepted PY - 2011/5/24/entrez PY - 2011/5/24/pubmed PY - 2012/1/5/medline SP - 31 EP - 9 JF - Virus research JO - Virus Res VL - 161 IS - 1 N2 - Molecular characterization of various hepatitis E virus (HEV) strains circulating among humans and animals (particularly swine, deer and boars) in different countries has revealed substantial genetic heterogeneity. The distinctive four-genotype distribution worldwide of mammalian HEV and varying degrees of genetic relatedness among local strains suggest a long and complex evolution of HEV in different geographic regions. The population expansion likely experienced by mammalian HEV in the second half of the 20th century is consistent with an extensive genetic divergence of HEV strains and high prevalence of HEV infections in many parts of the world, including developed countries. The rate and mechanisms of human-to-human transmission and zoonotic transmission to humans vary geographically, thus contributing to the complexity of HEV molecular evolution. SN - 1872-7492 UR - https://www.unboundmedicine.com/medline/citation/21600939/The_molecular_epidemiology_of_hepatitis_E_virus_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(11)00167-5 DB - PRIME DP - Unbound Medicine ER -