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Importance and benefits of dietary sodium restriction in the management of chronic kidney disease patients: experience from a single Chinese center.
Int Urol Nephrol. 2012 Apr; 44(2):549-56.IU

Abstract

AIM

Several studies have suggested that sodium intake may affect blood pressure (BP), proteinuria, and intrarenal transforming growth factor-β1 (TGF-β1) production in patients and animal models with chronic kidney disease (CKD). The Chinese population has a high prevalence of CKD and is well known for consuming salty foods. This study will investigate the role of dietary sodium intake on BP control among non-dialysis Chinese CKD patients.

METHODS

A cross-sectional study was carried out in a cohort of 176 non-dialysis hypertensive CKD patients to investigate their sodium intake and its effect on BP control by measuring 24-h urine sodium excretion (24-h UNa). A total of 20 patients with immunoglobulin A nephropathy (IgAN) participated in a 7-day sodium restriction study (100 mmol/day). Their changes in BP, proteinuria, and urinary TGF-β1 excretion were subsequently analyzed. Another 23 IgAN patients without salt restriction were included as controls.

RESULTS

The average 24-h UNa of the study cohort was 149.0 ± 66.4 mmol/day. Only 31.8% patients had a 24-h UNa less than 100 mmol/day. The OR for each 17 mmol increment in 24-h UNa (salt 1 g/day) for BP > 130/80 mmHg was 1.26 (95% CI 1.10-1.44, P = 0.001). The sodium restriction group achieved significantly more reduction in SBP (-11.1 mmHg vs. -5.0 mmHg, P = 0.022), DBP (-9.4 mmHg vs. -2.1 mmHg, P = 0.009), and urine protein excretion [-465 (-855 to -340) mg/day vs. -150 (-570 to 40) mg/day, P = 0.024]. A positive correlation was observed between the change of 24-h UNa and the change of SBP (r = 0.450, P = 0.047) in the sodium restriction group. The change of 24-h UNa was also correlated with the 24-h TGF-β1 excretion (r = 0.558, P = 0.011) in these patients.

CONCLUSION

Dietary sodium intake restriction should be monitored and intensified in the treatment of Chinese CKD patients.

Authors+Show Affiliations

Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, No. 8, Xishiku Street, 100034 Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21603903

Citation

Yu, Wang, et al. "Importance and Benefits of Dietary Sodium Restriction in the Management of Chronic Kidney Disease Patients: Experience From a Single Chinese Center." International Urology and Nephrology, vol. 44, no. 2, 2012, pp. 549-56.
Yu W, Luying S, Haiyan W, et al. Importance and benefits of dietary sodium restriction in the management of chronic kidney disease patients: experience from a single Chinese center. Int Urol Nephrol. 2012;44(2):549-56.
Yu, W., Luying, S., Haiyan, W., & Xiaomei, L. (2012). Importance and benefits of dietary sodium restriction in the management of chronic kidney disease patients: experience from a single Chinese center. International Urology and Nephrology, 44(2), 549-56. https://doi.org/10.1007/s11255-011-9986-x
Yu W, et al. Importance and Benefits of Dietary Sodium Restriction in the Management of Chronic Kidney Disease Patients: Experience From a Single Chinese Center. Int Urol Nephrol. 2012;44(2):549-56. PubMed PMID: 21603903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Importance and benefits of dietary sodium restriction in the management of chronic kidney disease patients: experience from a single Chinese center. AU - Yu,Wang, AU - Luying,Sun, AU - Haiyan,Wang, AU - Xiaomei,Li, Y1 - 2011/05/21/ PY - 2011/01/19/received PY - 2011/04/29/accepted PY - 2011/5/24/entrez PY - 2011/5/24/pubmed PY - 2012/8/1/medline SP - 549 EP - 56 JF - International urology and nephrology JO - Int Urol Nephrol VL - 44 IS - 2 N2 - AIM: Several studies have suggested that sodium intake may affect blood pressure (BP), proteinuria, and intrarenal transforming growth factor-β1 (TGF-β1) production in patients and animal models with chronic kidney disease (CKD). The Chinese population has a high prevalence of CKD and is well known for consuming salty foods. This study will investigate the role of dietary sodium intake on BP control among non-dialysis Chinese CKD patients. METHODS: A cross-sectional study was carried out in a cohort of 176 non-dialysis hypertensive CKD patients to investigate their sodium intake and its effect on BP control by measuring 24-h urine sodium excretion (24-h UNa). A total of 20 patients with immunoglobulin A nephropathy (IgAN) participated in a 7-day sodium restriction study (100 mmol/day). Their changes in BP, proteinuria, and urinary TGF-β1 excretion were subsequently analyzed. Another 23 IgAN patients without salt restriction were included as controls. RESULTS: The average 24-h UNa of the study cohort was 149.0 ± 66.4 mmol/day. Only 31.8% patients had a 24-h UNa less than 100 mmol/day. The OR for each 17 mmol increment in 24-h UNa (salt 1 g/day) for BP > 130/80 mmHg was 1.26 (95% CI 1.10-1.44, P = 0.001). The sodium restriction group achieved significantly more reduction in SBP (-11.1 mmHg vs. -5.0 mmHg, P = 0.022), DBP (-9.4 mmHg vs. -2.1 mmHg, P = 0.009), and urine protein excretion [-465 (-855 to -340) mg/day vs. -150 (-570 to 40) mg/day, P = 0.024]. A positive correlation was observed between the change of 24-h UNa and the change of SBP (r = 0.450, P = 0.047) in the sodium restriction group. The change of 24-h UNa was also correlated with the 24-h TGF-β1 excretion (r = 0.558, P = 0.011) in these patients. CONCLUSION: Dietary sodium intake restriction should be monitored and intensified in the treatment of Chinese CKD patients. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/21603903/Importance_and_benefits_of_dietary_sodium_restriction_in_the_management_of_chronic_kidney_disease_patients:_experience_from_a_single_Chinese_center_ L2 - https://doi.org/10.1007/s11255-011-9986-x DB - PRIME DP - Unbound Medicine ER -