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A compressibility and compactibility study of real tableting mixtures: the impact of wet and dry granulation versus a direct tableting mixture.
Int J Pharm. 2011 Jul 29; 414(1-2):131-9.IJ

Abstract

The purpose of this study was to investigate the influence of various powder agglomeration processes on tableting mixture flow and compaction properties. Four different granulation methods of the same model placebo formulation were tested at a semi-industrial scale and their properties were compared to those of the directly compressed mixture. The wet granulated mixtures had superior flow properties compared to other mixtures and showed better compressibility, measured by the Heckel and Walker models. This was attributed to work hardening due to the double particle processing and also to shorter contact times due to higher initial densities of dry granulated mixtures, allowing a shorter time for deformation. A strong linear correlation was established between the Heckel and Walker coefficients, which was further confirmed by the net energy results of force-displacement measurements. It was shown that the Walker model had slightly better discriminative power to differentiate tableting mixtures according to compressibility. The compactibility was considerably lower for the slugged mixture; however, the roller-compacted mixture produced tablets with unexpectedly high tensile strength. In conclusion, it is important to emphasize that general assumptions like higher porosity => better compressibility or better compressibility => better compactibility cannot be established for complex tableting mixtures.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Šantl M
Krka dd, Novo Mesto, Šmarješka cesta 6, 8501 Novo Mesto, Slovenia.
Ilić I
No affiliation info available
Vrečer F
No affiliation info available
Baumgartner S
No affiliation info available

MeSH

Antineoplastic Combined Chemotherapy ProtocolsCompressive StrengthDrug Delivery SystemsExcipientsModels, TheoreticalParticle SizePlacebosPorosityPowdersPressureTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21605646

Citation

Šantl, Maja, et al. "A Compressibility and Compactibility Study of Real Tableting Mixtures: the Impact of Wet and Dry Granulation Versus a Direct Tableting Mixture." International Journal of Pharmaceutics, vol. 414, no. 1-2, 2011, pp. 131-9.
Šantl M, Ilić I, Vrečer F, et al. A compressibility and compactibility study of real tableting mixtures: the impact of wet and dry granulation versus a direct tableting mixture. Int J Pharm. 2011;414(1-2):131-9.
Šantl, M., Ilić, I., Vrečer, F., & Baumgartner, S. (2011). A compressibility and compactibility study of real tableting mixtures: the impact of wet and dry granulation versus a direct tableting mixture. International Journal of Pharmaceutics, 414(1-2), 131-9. https://doi.org/10.1016/j.ijpharm.2011.05.025
Šantl M, et al. A Compressibility and Compactibility Study of Real Tableting Mixtures: the Impact of Wet and Dry Granulation Versus a Direct Tableting Mixture. Int J Pharm. 2011 Jul 29;414(1-2):131-9. PubMed PMID: 21605646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A compressibility and compactibility study of real tableting mixtures: the impact of wet and dry granulation versus a direct tableting mixture. AU - Šantl,Maja, AU - Ilić,Ilija, AU - Vrečer,Franc, AU - Baumgartner,Saša, Y1 - 2011/05/12/ PY - 2011/01/21/received PY - 2011/05/03/revised PY - 2011/05/05/accepted PY - 2011/5/25/entrez PY - 2011/5/25/pubmed PY - 2012/2/7/medline SP - 131 EP - 9 JF - International journal of pharmaceutics JO - Int J Pharm VL - 414 IS - 1-2 N2 - The purpose of this study was to investigate the influence of various powder agglomeration processes on tableting mixture flow and compaction properties. Four different granulation methods of the same model placebo formulation were tested at a semi-industrial scale and their properties were compared to those of the directly compressed mixture. The wet granulated mixtures had superior flow properties compared to other mixtures and showed better compressibility, measured by the Heckel and Walker models. This was attributed to work hardening due to the double particle processing and also to shorter contact times due to higher initial densities of dry granulated mixtures, allowing a shorter time for deformation. A strong linear correlation was established between the Heckel and Walker coefficients, which was further confirmed by the net energy results of force-displacement measurements. It was shown that the Walker model had slightly better discriminative power to differentiate tableting mixtures according to compressibility. The compactibility was considerably lower for the slugged mixture; however, the roller-compacted mixture produced tablets with unexpectedly high tensile strength. In conclusion, it is important to emphasize that general assumptions like higher porosity => better compressibility or better compressibility => better compactibility cannot be established for complex tableting mixtures. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/21605646/A_compressibility_and_compactibility_study_of_real_tableting_mixtures:_the_impact_of_wet_and_dry_granulation_versus_a_direct_tableting_mixture_ DB - PRIME DP - Unbound Medicine ER -