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Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats.
Pediatr Nephrol 2011; 26(11):2019-29PN

Abstract

The role of α-tocopherol during nephrogenesis was investigated in rats subjected to maternal undernutrition, which reduces the number of nephrons. α-tocopherol (350 mg/kg, p.o.) was administered daily to well-nourished or malnourished Wistar dams during pregnancy, or to prenatal undernourished rats during lactation. The kidneys of 1- and 25-day-old offspring were removed to evaluate expression of angiotensin II (Ang II) and to correlate this with expression of proliferating cell nuclear antigen, α-smooth muscle actin, fibronectin and vimentin in the glomeruli and tubulointerstitial space. One-day-old prenatally undernourished rats had reduced expression of Ang II and of kidney development markers, and presented with an enlarged nephrogenic zone. Maternal administration of α-tocopherol restored the features of normal kidney development in undernourished rats. Twenty-five-day-old prenatally undernourished progeny had fewer glomeruli than the control group. Conversely, animals from mothers that received α-tocopherol during lactation presented with the same number of glomeruli and the same glomerular morphometrical profile as the control group. Analyzing the levels of thiobarbituric acid reactive substances in the liver in conjunction with kidney development markers, it is plausible that α-tocopherol had antioxidant and non-antioxidant actions. This study provides evidence that α-tocopherol treatment restored Ang II expression, and subsequently restored renal structural development.

Authors+Show Affiliations

Departamento de Fisiologia e Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, s/n, Cidade Universitária 50670-901, Recife, PE, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21607627

Citation

Vieira-Filho, Leucio D., et al. "Alpha-tocopherol Prevents Intrauterine Undernutrition-induced Oligonephronia in Rats." Pediatric Nephrology (Berlin, Germany), vol. 26, no. 11, 2011, pp. 2019-29.
Vieira-Filho LD, Cabral EV, Santos FT, et al. Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats. Pediatr Nephrol. 2011;26(11):2019-29.
Vieira-Filho, L. D., Cabral, E. V., Santos, F. T., Coimbra, T. M., & Paixão, A. D. (2011). Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats. Pediatric Nephrology (Berlin, Germany), 26(11), pp. 2019-29. doi:10.1007/s00467-011-1908-8.
Vieira-Filho LD, et al. Alpha-tocopherol Prevents Intrauterine Undernutrition-induced Oligonephronia in Rats. Pediatr Nephrol. 2011;26(11):2019-29. PubMed PMID: 21607627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats. AU - Vieira-Filho,Leucio D, AU - Cabral,Edjair Vicente, AU - Santos,Felipe T J, AU - Coimbra,Terezila M, AU - Paixão,Ana D O, Y1 - 2011/05/24/ PY - 2010/12/14/received PY - 2011/04/25/accepted PY - 2011/04/22/revised PY - 2011/5/25/entrez PY - 2011/5/25/pubmed PY - 2012/1/27/medline SP - 2019 EP - 29 JF - Pediatric nephrology (Berlin, Germany) JO - Pediatr. Nephrol. VL - 26 IS - 11 N2 - The role of α-tocopherol during nephrogenesis was investigated in rats subjected to maternal undernutrition, which reduces the number of nephrons. α-tocopherol (350 mg/kg, p.o.) was administered daily to well-nourished or malnourished Wistar dams during pregnancy, or to prenatal undernourished rats during lactation. The kidneys of 1- and 25-day-old offspring were removed to evaluate expression of angiotensin II (Ang II) and to correlate this with expression of proliferating cell nuclear antigen, α-smooth muscle actin, fibronectin and vimentin in the glomeruli and tubulointerstitial space. One-day-old prenatally undernourished rats had reduced expression of Ang II and of kidney development markers, and presented with an enlarged nephrogenic zone. Maternal administration of α-tocopherol restored the features of normal kidney development in undernourished rats. Twenty-five-day-old prenatally undernourished progeny had fewer glomeruli than the control group. Conversely, animals from mothers that received α-tocopherol during lactation presented with the same number of glomeruli and the same glomerular morphometrical profile as the control group. Analyzing the levels of thiobarbituric acid reactive substances in the liver in conjunction with kidney development markers, it is plausible that α-tocopherol had antioxidant and non-antioxidant actions. This study provides evidence that α-tocopherol treatment restored Ang II expression, and subsequently restored renal structural development. SN - 1432-198X UR - https://www.unboundmedicine.com/medline/citation/21607627/Alpha-tocopherol_prevents_intrauterine_undernutrition-induced_oligonephronia_in_rats L2 - https://dx.doi.org/10.1007/s00467-011-1908-8 DB - PRIME DP - Unbound Medicine ER -