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Effect of rimonabant on carotid intima-media thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial.
Heart. 2011 Jul; 97(14):1143-50.H

Abstract

OBJECTIVE

The aim of this trial was to determine whether obese patients benefit from treatment with rimonabant in terms of progression of carotid atherosclerosis. Rimonabant, a selective cannabinoid-1 receptor blocker, reduces body weight and improves cardiometabolic risk factors in patients who are obese.

DESIGN, SETTING, PATIENTS, INTERVENTIONS AND RESULTS

A prospective, double-blind, placebo-controlled trial (Atherosclerosis Underlying Development assessed by Intima-media Thickness in patients On Rimonabant (AUDITOR)) randomised 661 patients with abdominal obesity and metabolic syndrome to rimonabant or placebo for 30 months of treatment. The absolute change in the average value for six segments of far wall carotid intima-media thickness from baseline to month 30 was 0.010 ± 0.095 mm in the rimonabant group and 0.012 ± 0.091 mm in the placebo group (p=0.67). The annualised change was an increase of 0.005 ± 0.042 mm for the rimonabant-treated group and 0.007 ± 0.043 mm for the placebo-treated group (p=0.45).

CONCLUSIONS

There was no difference in atherosclerosis progression between patients receiving rimonabant for 30 months and those receiving placebo for the primary efficacy measure (absolute change in carotid intima-media thickness). These findings are consistent with a similar study using coronary intravascular ultrasound and another study evaluating the occurrence of cardiovascular events. Our findings suggest that a 5% loss of body weight over a 30-month period with rimonabant is insufficient to modify atherosclerosis progression in the carotid artery in obese patients with metabolic syndrome. Clinical trial registration information clinicaltrials.gov Identifier: NCT00228176.

Authors+Show Affiliations

Department of Vascular Medicine, Academic Medical Center, AZ Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21610270

Citation

O'Leary, Daniel H., et al. "Effect of Rimonabant On Carotid Intima-media Thickness (CIMT) Progression in Patients With Abdominal Obesity and Metabolic Syndrome: the AUDITOR Trial." Heart (British Cardiac Society), vol. 97, no. 14, 2011, pp. 1143-50.
O'Leary DH, Reuwer AQ, Nissen SE, et al. Effect of rimonabant on carotid intima-media thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial. Heart. 2011;97(14):1143-50.
O'Leary, D. H., Reuwer, A. Q., Nissen, S. E., Després, J. P., Deanfield, J. E., Brown, M. W., Zhou, R., Zabbatino, S. M., Job, B., Kastelein, J. J., & Visseren, F. L. (2011). Effect of rimonabant on carotid intima-media thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial. Heart (British Cardiac Society), 97(14), 1143-50. https://doi.org/10.1136/hrt.2011.223446
O'Leary DH, et al. Effect of Rimonabant On Carotid Intima-media Thickness (CIMT) Progression in Patients With Abdominal Obesity and Metabolic Syndrome: the AUDITOR Trial. Heart. 2011;97(14):1143-50. PubMed PMID: 21610270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of rimonabant on carotid intima-media thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial. AU - O'Leary,Daniel H, AU - Reuwer,Anne Q, AU - Nissen,Steven E, AU - Després,Jean-Pierre, AU - Deanfield,John E, AU - Brown,Michael W, AU - Zhou,Rong, AU - Zabbatino,Salvatore M, AU - Job,Bernard, AU - Kastelein,John J P, AU - Visseren,Frank L J, AU - ,, Y1 - 2011/05/24/ PY - 2011/5/26/entrez PY - 2011/5/26/pubmed PY - 2011/11/1/medline SP - 1143 EP - 50 JF - Heart (British Cardiac Society) JO - Heart VL - 97 IS - 14 N2 - OBJECTIVE: The aim of this trial was to determine whether obese patients benefit from treatment with rimonabant in terms of progression of carotid atherosclerosis. Rimonabant, a selective cannabinoid-1 receptor blocker, reduces body weight and improves cardiometabolic risk factors in patients who are obese. DESIGN, SETTING, PATIENTS, INTERVENTIONS AND RESULTS: A prospective, double-blind, placebo-controlled trial (Atherosclerosis Underlying Development assessed by Intima-media Thickness in patients On Rimonabant (AUDITOR)) randomised 661 patients with abdominal obesity and metabolic syndrome to rimonabant or placebo for 30 months of treatment. The absolute change in the average value for six segments of far wall carotid intima-media thickness from baseline to month 30 was 0.010 ± 0.095 mm in the rimonabant group and 0.012 ± 0.091 mm in the placebo group (p=0.67). The annualised change was an increase of 0.005 ± 0.042 mm for the rimonabant-treated group and 0.007 ± 0.043 mm for the placebo-treated group (p=0.45). CONCLUSIONS: There was no difference in atherosclerosis progression between patients receiving rimonabant for 30 months and those receiving placebo for the primary efficacy measure (absolute change in carotid intima-media thickness). These findings are consistent with a similar study using coronary intravascular ultrasound and another study evaluating the occurrence of cardiovascular events. Our findings suggest that a 5% loss of body weight over a 30-month period with rimonabant is insufficient to modify atherosclerosis progression in the carotid artery in obese patients with metabolic syndrome. Clinical trial registration information clinicaltrials.gov Identifier: NCT00228176. SN - 1468-201X UR - https://www.unboundmedicine.com/medline/citation/21610270/Effect_of_rimonabant_on_carotid_intima_media_thickness__CIMT__progression_in_patients_with_abdominal_obesity_and_metabolic_syndrome:_the_AUDITOR_Trial_ L2 - https://heart.bmj.com/lookup/pmidlookup?view=long&pmid=21610270 DB - PRIME DP - Unbound Medicine ER -