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Optimum dose of ketamine for prevention of postanesthetic shivering; a randomized double-blind placebo-controlled clinical trial.
Acta Anaesthesiol Belg. 2011; 62(1):33-6.AA

Abstract

Our objective was to investigate the efficacy and the optimum dosage of ketamine for post anesthetic shivering prevention. One-hundred and twenty patients (ASA I-II) scheduled for elective orthopedic surgery were randomly allocated to receive ketamine in 3 groups ; groups A (0.125 mg/Kg), groups B (0.25 mg/Kg) and C (0.5 mg/Kg) along with those receiving 0.9% normal saline as the placebo group. Tympanic temperature was measured immediately after induction of anesthesia, 30 min after induction, before administration of the study drug and by the end of the surgery. The four groups did not differ significantly in their hemodynamic parameters and tympanic temperature. The frequency of shivering was significantly less in groups B (0.25 mg/Kg) and C (0.5 mg/Kg) than in groups A (0.125 mg/Kg) and D (placebo). In addition recovery, extubation time and hallucination was observed to be less in group B compared to group A. Prophylactic 0.25 and 0.5 mg/kg ketamine was found to be effective in preventing postanesthetic shivering with a better response observed with 0.25 mg/kg dosage.

Authors+Show Affiliations

Department of Anesthesiology, Kerman University of Medical Sciences, Kerman, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21612143

Citation

Norouzi, M, et al. "Optimum Dose of Ketamine for Prevention of Postanesthetic Shivering; a Randomized Double-blind Placebo-controlled Clinical Trial." Acta Anaesthesiologica Belgica, vol. 62, no. 1, 2011, pp. 33-6.
Norouzi M, Doroodian MR, Salajegheh S. Optimum dose of ketamine for prevention of postanesthetic shivering; a randomized double-blind placebo-controlled clinical trial. Acta Anaesthesiol Belg. 2011;62(1):33-6.
Norouzi, M., Doroodian, M. R., & Salajegheh, S. (2011). Optimum dose of ketamine for prevention of postanesthetic shivering; a randomized double-blind placebo-controlled clinical trial. Acta Anaesthesiologica Belgica, 62(1), 33-6.
Norouzi M, Doroodian MR, Salajegheh S. Optimum Dose of Ketamine for Prevention of Postanesthetic Shivering; a Randomized Double-blind Placebo-controlled Clinical Trial. Acta Anaesthesiol Belg. 2011;62(1):33-6. PubMed PMID: 21612143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimum dose of ketamine for prevention of postanesthetic shivering; a randomized double-blind placebo-controlled clinical trial. AU - Norouzi,M, AU - Doroodian,M R, AU - Salajegheh,S, PY - 2011/5/27/entrez PY - 2011/5/27/pubmed PY - 2011/6/15/medline SP - 33 EP - 6 JF - Acta anaesthesiologica Belgica JO - Acta Anaesthesiol Belg VL - 62 IS - 1 N2 - Our objective was to investigate the efficacy and the optimum dosage of ketamine for post anesthetic shivering prevention. One-hundred and twenty patients (ASA I-II) scheduled for elective orthopedic surgery were randomly allocated to receive ketamine in 3 groups ; groups A (0.125 mg/Kg), groups B (0.25 mg/Kg) and C (0.5 mg/Kg) along with those receiving 0.9% normal saline as the placebo group. Tympanic temperature was measured immediately after induction of anesthesia, 30 min after induction, before administration of the study drug and by the end of the surgery. The four groups did not differ significantly in their hemodynamic parameters and tympanic temperature. The frequency of shivering was significantly less in groups B (0.25 mg/Kg) and C (0.5 mg/Kg) than in groups A (0.125 mg/Kg) and D (placebo). In addition recovery, extubation time and hallucination was observed to be less in group B compared to group A. Prophylactic 0.25 and 0.5 mg/kg ketamine was found to be effective in preventing postanesthetic shivering with a better response observed with 0.25 mg/kg dosage. SN - 0001-5164 UR - https://www.unboundmedicine.com/medline/citation/21612143/Optimum_dose_of_ketamine_for_prevention_of_postanesthetic_shivering L2 - https://medlineplus.gov/anesthesia.html DB - PRIME DP - Unbound Medicine ER -