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Development and characterization of mucoadhesive microspheres for nasal delivery of ketorolac.
Pharmazie. 2011 Apr; 66(4):249-57.P

Abstract

The objective of the present investigation was to prepare mucoadhesive microspheres of ketorolac for nasal administration by means of a solvent evaporation technique using carbopol (CP), polycarbophil (PL) and chitosan (CS) as mucoadhesive polymers. The prepared microspheres were characterized for morphology, swelling behavior, mucoadhesion, interaction studies, drug encapsulation efficiency, in vitro drug release, release kinetics, and ex vivo nasal cilio toxicity studies. The effects of various process variables on the particle size of the microspheres were investigated. Drug encapsulation efficiency and particle size of the microspheres ranged from 52-78% w/w and 14-46 microm respectively. Interaction studies revealed that there were no drug-polymer interactions. The in vitro release profiles showed prolonged-release of the drug. In vitro release data showed a good fit with the Higuchi model, and indicated Fickian diffusion. No severe damage was found to the integrity of nasal mucosa after ex vivo experiments.

Authors+Show Affiliations

Induakaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Anand, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21612151

Citation

Nagda, C D., et al. "Development and Characterization of Mucoadhesive Microspheres for Nasal Delivery of Ketorolac." Die Pharmazie, vol. 66, no. 4, 2011, pp. 249-57.
Nagda CD, Chotai NP, Nagda DC, et al. Development and characterization of mucoadhesive microspheres for nasal delivery of ketorolac. Pharmazie. 2011;66(4):249-57.
Nagda, C. D., Chotai, N. P., Nagda, D. C., Patel, S. B., & Patel, U. L. (2011). Development and characterization of mucoadhesive microspheres for nasal delivery of ketorolac. Die Pharmazie, 66(4), 249-57.
Nagda CD, et al. Development and Characterization of Mucoadhesive Microspheres for Nasal Delivery of Ketorolac. Pharmazie. 2011;66(4):249-57. PubMed PMID: 21612151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and characterization of mucoadhesive microspheres for nasal delivery of ketorolac. AU - Nagda,C D, AU - Chotai,N P, AU - Nagda,D C, AU - Patel,S B, AU - Patel,U L, PY - 2011/5/27/entrez PY - 2011/5/27/pubmed PY - 2011/6/16/medline SP - 249 EP - 57 JF - Die Pharmazie JO - Pharmazie VL - 66 IS - 4 N2 - The objective of the present investigation was to prepare mucoadhesive microspheres of ketorolac for nasal administration by means of a solvent evaporation technique using carbopol (CP), polycarbophil (PL) and chitosan (CS) as mucoadhesive polymers. The prepared microspheres were characterized for morphology, swelling behavior, mucoadhesion, interaction studies, drug encapsulation efficiency, in vitro drug release, release kinetics, and ex vivo nasal cilio toxicity studies. The effects of various process variables on the particle size of the microspheres were investigated. Drug encapsulation efficiency and particle size of the microspheres ranged from 52-78% w/w and 14-46 microm respectively. Interaction studies revealed that there were no drug-polymer interactions. The in vitro release profiles showed prolonged-release of the drug. In vitro release data showed a good fit with the Higuchi model, and indicated Fickian diffusion. No severe damage was found to the integrity of nasal mucosa after ex vivo experiments. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/21612151/Development_and_characterization_of_mucoadhesive_microspheres_for_nasal_delivery_of_ketorolac_ DB - PRIME DP - Unbound Medicine ER -