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Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences.
Psychoneuroendocrinology 2011; 36(10):1570-81P

Abstract

An apparent clinical relationship between pain and depression has long been recognized. Depression and pain are often diagnosed in the same patients. The emerging concept for pain-depression pathogenesis is the dysfunction of biogenic amine-mediated pain-depression control and the possible involvement of nitrodative stress-induced neurogenic inflammation. The present study was designed to investigate the effect of curcumin on reserpine-induced pain-depression dyad in rats. Administration of reserpine (1mg/kg subcutaneous daily for three consecutive days) led to a significant decrease in nociceptive threshold as evident from reduced paw withdrawal threshold in Randall Sellitto and von-Frey hair test as well as significant increase in immobility time in forced swim test. This behavioural deficit was integrated with decrease in the biogenic amine (dopamine, norepinephrine and serotonin) levels along with increased substance P concentration, nitrodative stress, inflammatory cytokines, NF-κβ and caspase-3 levels in different brain regions (cortex and hippocampus) of the reserpinised rats. Curcumin (100, 200, 300mg/kg; ip) dose dependently ameliorated the behavioural deficits associated with pain and depression by restoring behavioural, biochemical, neurochemical and molecular alterations against reserpine-induced pain-depression dyad in rats.

Authors+Show Affiliations

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21612876

Citation

Arora, V, et al. "Curcumin Ameliorates Reserpine-induced Pain-depression Dyad: Behavioural, Biochemical, Neurochemical and Molecular Evidences." Psychoneuroendocrinology, vol. 36, no. 10, 2011, pp. 1570-81.
Arora V, Kuhad A, Tiwari V, et al. Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. Psychoneuroendocrinology. 2011;36(10):1570-81.
Arora, V., Kuhad, A., Tiwari, V., & Chopra, K. (2011). Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. Psychoneuroendocrinology, 36(10), pp. 1570-81. doi:10.1016/j.psyneuen.2011.04.012.
Arora V, et al. Curcumin Ameliorates Reserpine-induced Pain-depression Dyad: Behavioural, Biochemical, Neurochemical and Molecular Evidences. Psychoneuroendocrinology. 2011;36(10):1570-81. PubMed PMID: 21612876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. AU - Arora,V, AU - Kuhad,A, AU - Tiwari,V, AU - Chopra,K, Y1 - 2011/05/25/ PY - 2011/02/01/received PY - 2011/04/21/revised PY - 2011/04/22/accepted PY - 2011/5/27/entrez PY - 2011/5/27/pubmed PY - 2012/3/6/medline SP - 1570 EP - 81 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 36 IS - 10 N2 - An apparent clinical relationship between pain and depression has long been recognized. Depression and pain are often diagnosed in the same patients. The emerging concept for pain-depression pathogenesis is the dysfunction of biogenic amine-mediated pain-depression control and the possible involvement of nitrodative stress-induced neurogenic inflammation. The present study was designed to investigate the effect of curcumin on reserpine-induced pain-depression dyad in rats. Administration of reserpine (1mg/kg subcutaneous daily for three consecutive days) led to a significant decrease in nociceptive threshold as evident from reduced paw withdrawal threshold in Randall Sellitto and von-Frey hair test as well as significant increase in immobility time in forced swim test. This behavioural deficit was integrated with decrease in the biogenic amine (dopamine, norepinephrine and serotonin) levels along with increased substance P concentration, nitrodative stress, inflammatory cytokines, NF-κβ and caspase-3 levels in different brain regions (cortex and hippocampus) of the reserpinised rats. Curcumin (100, 200, 300mg/kg; ip) dose dependently ameliorated the behavioural deficits associated with pain and depression by restoring behavioural, biochemical, neurochemical and molecular alterations against reserpine-induced pain-depression dyad in rats. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/21612876/Curcumin_ameliorates_reserpine_induced_pain_depression_dyad:_behavioural_biochemical_neurochemical_and_molecular_evidences_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(11)00136-3 DB - PRIME DP - Unbound Medicine ER -