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Role of oxidative stress and antioxidant supplementation in pregnancy disorders.
Am J Clin Nutr 2011; 94(6 Suppl):1980S-1985SAJ

Abstract

Oxidative stress is widely implicated in failed reproductive performance, including infertility, miscarriage, diabetes-related congenital malformations, and preeclampsia. Maternal obesity is a strong risk factor for preeclampsia, and in a recent study we observed oxidative stress in the oocytes of obese animals before pregnancy as well as in early-stage embryos. This adds to the growing evidence that investigators need to focus more on the preconceptual period in efforts to prevent pregnancy disorders, including those related to oxidative stress. Our research has also focused on the role of free radicals and antioxidant capacity in preeclampsia. By measuring markers of lipid peroxidation and antioxidant capacity, we obtained unequivocal evidence for oxidative stress in this disorder. Partial failure of the process of placentation has been implicated, and recent findings suggest that ischemia-reperfusion in the placenta may contribute to oxidative stress in trophoblasts. Endoplasmic reticulum stress in the placenta may also play a role. Randomized controlled trials have been conducted by our group as well as others to determine whether early supplementation with vitamins C and E in women at risk of preeclampsia is beneficial, but these trials have shown no evidence that these supplements can prevent preeclampsia. Whether this indicates that an inappropriate antioxidant strategy was used or supplementation was administered too late in gestation to be beneficial is not known. Other potential approaches for preventing preeclampsia through amelioration of oxidative stress include the use of supplements in the preconceptual period, selenium supplements, antiperoxynitrite strategies, and statins.

Authors+Show Affiliations

Division of Women's Health, King's College London, Kings Health Partners-Women's Health, Clinical Academic Grouping, London, United Kingdom. lucilla.poston@kcl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21613560

Citation

Poston, Lucilla, et al. "Role of Oxidative Stress and Antioxidant Supplementation in Pregnancy Disorders." The American Journal of Clinical Nutrition, vol. 94, no. 6 Suppl, 2011, 1980S-1985S.
Poston L, Igosheva N, Mistry HD, et al. Role of oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr. 2011;94(6 Suppl):1980S-1985S.
Poston, L., Igosheva, N., Mistry, H. D., Seed, P. T., Shennan, A. H., Rana, S., ... Chappell, L. C. (2011). Role of oxidative stress and antioxidant supplementation in pregnancy disorders. The American Journal of Clinical Nutrition, 94(6 Suppl), 1980S-1985S. doi:10.3945/ajcn.110.001156.
Poston L, et al. Role of Oxidative Stress and Antioxidant Supplementation in Pregnancy Disorders. Am J Clin Nutr. 2011;94(6 Suppl):1980S-1985S. PubMed PMID: 21613560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of oxidative stress and antioxidant supplementation in pregnancy disorders. AU - Poston,Lucilla, AU - Igosheva,Natalia, AU - Mistry,Hiten D, AU - Seed,Paul T, AU - Shennan,Andrew H, AU - Rana,Sarosh, AU - Karumanchi,S Ananth, AU - Chappell,Lucy C, Y1 - 2011/05/25/ PY - 2011/5/27/entrez PY - 2011/5/27/pubmed PY - 2012/2/14/medline SP - 1980S EP - 1985S JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 94 IS - 6 Suppl N2 - Oxidative stress is widely implicated in failed reproductive performance, including infertility, miscarriage, diabetes-related congenital malformations, and preeclampsia. Maternal obesity is a strong risk factor for preeclampsia, and in a recent study we observed oxidative stress in the oocytes of obese animals before pregnancy as well as in early-stage embryos. This adds to the growing evidence that investigators need to focus more on the preconceptual period in efforts to prevent pregnancy disorders, including those related to oxidative stress. Our research has also focused on the role of free radicals and antioxidant capacity in preeclampsia. By measuring markers of lipid peroxidation and antioxidant capacity, we obtained unequivocal evidence for oxidative stress in this disorder. Partial failure of the process of placentation has been implicated, and recent findings suggest that ischemia-reperfusion in the placenta may contribute to oxidative stress in trophoblasts. Endoplasmic reticulum stress in the placenta may also play a role. Randomized controlled trials have been conducted by our group as well as others to determine whether early supplementation with vitamins C and E in women at risk of preeclampsia is beneficial, but these trials have shown no evidence that these supplements can prevent preeclampsia. Whether this indicates that an inappropriate antioxidant strategy was used or supplementation was administered too late in gestation to be beneficial is not known. Other potential approaches for preventing preeclampsia through amelioration of oxidative stress include the use of supplements in the preconceptual period, selenium supplements, antiperoxynitrite strategies, and statins. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/21613560/Role_of_oxidative_stress_and_antioxidant_supplementation_in_pregnancy_disorders_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.110.001156 DB - PRIME DP - Unbound Medicine ER -