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Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome.
Thromb Haemost. 2011 Jul; 106(1):132-40.TH

Abstract

Mean platelet volume (MPV) has been proposed as a marker of platelet reactivity and cardiovascular risk. Its prognostic significance has not been thoroughly investigated in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). We included 1,041 consecutive patients with NSTE-ACS. Patients were divided in quartiles according to the MPV value on admission (fl) i.e. Q1<7.5; Q2=7.5-8.0; Q3=8.1-8.8; Q4≥8.9. The primary study endpoint was the composite of cardiovascular death and re-myocardial infarction (MI) at one year. Secondary study endpoints were individual cardiovascular death and re-MI. Patients in Q4 were older, had a higher prevalence of previous MI, peripheral artery disease and advanced Killip class compared to patients in Q1-Q3. Elevated MPV levels (Q4) was independently associated with gender, smoking status, platelet count and creatinine level. Overall, 210 patients (20.2%) reached the primary endpoint, 124 (12.1%) died from cardiovascular causes and 125 (12.0%) suffered from re-MI. On multivariable analysis patients in Q4 were at higher risk of primary endpoint (HR=1.41; 95%CI 1.06-1.89; p=0.02) whilst the association with cardiovascular death and re-MI was attenuated. MPV as continuous variable was independently associated with both primary endpoint (HR=1.19; 95%CI 1.06-1.33; p=0.003) and cardiovascular death (HR=1.23; 95%CI 1.06-1.42, p=0.006). The incorporation of MPV into a comprehensive model of risk significantly increased the likelihood ratio chi-square for prediction of both the composite endpoint (p=0.004) and cardiovascular death (p=0.009). Therefore, MPV may be useful to improve risk stratification in NSTE-ACS patients and should be included in future prospective studies evaluating the role of platelet function in promoting cardiovascular events.

Authors+Show Affiliations

Institute of Cardiology, St. Orsola/Malpighi Hospital, Bologna University, Bologna, Italy. neviotaglieri@hotmail.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21614413

Citation

Taglieri, Nevio, et al. "Prognostic Significance of Mean Platelet Volume On Admission in an Unselected Cohort of Patients With Non ST-segment Elevation Acute Coronary Syndrome." Thrombosis and Haemostasis, vol. 106, no. 1, 2011, pp. 132-40.
Taglieri N, Saia F, Rapezzi C, et al. Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome. Thromb Haemost. 2011;106(1):132-40.
Taglieri, N., Saia, F., Rapezzi, C., Marrozzini, C., Bacchi Reggiani, M. L., Palmerini, T., Ortolani, P., Melandri, G., Rosmini, S., Cinti, L., Alessi, L., Vagnarelli, F., Villani, C., Branzi, A., & Marzocchi, A. (2011). Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome. Thrombosis and Haemostasis, 106(1), 132-40. https://doi.org/10.1160/TH10-12-0821
Taglieri N, et al. Prognostic Significance of Mean Platelet Volume On Admission in an Unselected Cohort of Patients With Non ST-segment Elevation Acute Coronary Syndrome. Thromb Haemost. 2011;106(1):132-40. PubMed PMID: 21614413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome. AU - Taglieri,Nevio, AU - Saia,Francesco, AU - Rapezzi,Claudio, AU - Marrozzini,Cinzia, AU - Bacchi Reggiani,Maria Letizia, AU - Palmerini,Tullio, AU - Ortolani,Paolo, AU - Melandri,Giovanni, AU - Rosmini,Stefania, AU - Cinti,Laura, AU - Alessi,Laura, AU - Vagnarelli,Fabio, AU - Villani,Caterina, AU - Branzi,Angelo, AU - Marzocchi,Antonio, Y1 - 2011/05/26/ PY - 2010/12/28/received PY - 2011/04/08/accepted PY - 2011/5/27/entrez PY - 2011/5/27/pubmed PY - 2011/11/16/medline SP - 132 EP - 40 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 106 IS - 1 N2 - Mean platelet volume (MPV) has been proposed as a marker of platelet reactivity and cardiovascular risk. Its prognostic significance has not been thoroughly investigated in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). We included 1,041 consecutive patients with NSTE-ACS. Patients were divided in quartiles according to the MPV value on admission (fl) i.e. Q1<7.5; Q2=7.5-8.0; Q3=8.1-8.8; Q4≥8.9. The primary study endpoint was the composite of cardiovascular death and re-myocardial infarction (MI) at one year. Secondary study endpoints were individual cardiovascular death and re-MI. Patients in Q4 were older, had a higher prevalence of previous MI, peripheral artery disease and advanced Killip class compared to patients in Q1-Q3. Elevated MPV levels (Q4) was independently associated with gender, smoking status, platelet count and creatinine level. Overall, 210 patients (20.2%) reached the primary endpoint, 124 (12.1%) died from cardiovascular causes and 125 (12.0%) suffered from re-MI. On multivariable analysis patients in Q4 were at higher risk of primary endpoint (HR=1.41; 95%CI 1.06-1.89; p=0.02) whilst the association with cardiovascular death and re-MI was attenuated. MPV as continuous variable was independently associated with both primary endpoint (HR=1.19; 95%CI 1.06-1.33; p=0.003) and cardiovascular death (HR=1.23; 95%CI 1.06-1.42, p=0.006). The incorporation of MPV into a comprehensive model of risk significantly increased the likelihood ratio chi-square for prediction of both the composite endpoint (p=0.004) and cardiovascular death (p=0.009). Therefore, MPV may be useful to improve risk stratification in NSTE-ACS patients and should be included in future prospective studies evaluating the role of platelet function in promoting cardiovascular events. SN - 2567-689X UR - https://www.unboundmedicine.com/medline/citation/21614413/Prognostic_significance_of_mean_platelet_volume_on_admission_in_an_unselected_cohort_of_patients_with_non_ST_segment_elevation_acute_coronary_syndrome_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH10-12-0821 DB - PRIME DP - Unbound Medicine ER -