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Alcohol consumption, types of alcoholic beverages and risk of venous thromboembolism - the Tromsø Study.
Thromb Haemost 2011; 106(2):272-8TH

Abstract

Moderate alcohol consumption has been shown to protect against cardiovascular diseases. The association between alcohol consumption, especially types of alcoholic beverages, and venous thromboembolism (VTE) is less well described. The aim of this study was to investigate the impact of alcohol consumption and different alcoholic beverages on risk of VTE. Information on alcohol consumption was collected by a self-administrated questionnaire in 26,662 subjects, aged 25-97 years, who participated in the Tromsø Study, in 1994-1995. Subjects were followed through September 1, 2007 with incident VTE as the primary outcome. There were 460 incident VTE-events during a median of 12.5 years of follow-up. Total alcohol consumption was not associated with risk of incident VTE. However, subjects consuming ≥ 3 units of liquor per week had 53% increased risk of VTE compared to teetotalers in analyses adjusted for age, sex, body mass index, smoking, diabetes, cancer, previous cardiovascular disease, physical activity and higher education (HR: 1.53, 95% CI: 1.00-2.33). Contrary, subjects with a wine intake of ≥ 3 units/week had 22% reduced risk of VTE (HR: 0.78, 95% CI: 0.47-1.30), further adjustment for liquor and beer intake strengthened the protective effect of wine (HR: 0.53, 95% CI: 0.30-1.00). Frequent binge drinkers (≥ 1/week) had a 17% increased risk of VTE compared to teetotallers (HR 1.17, 95% CI: 0.66-2.09), and a 47% increased risk compared to non-binge drinkers (HR 1.47, 95% CI: 0.85-2.54). In conclusion, liquor consumption and binge drinking was associated with increased risk of VTE, whereas wine consumption was possibly associated with reduced risk of VTE.

Authors+Show Affiliations

Hematological research group in Tromsø (HERG), Department of Clinical Medicine, University of Tromsø, N-9037 Tromsø, Norway. ida.j.hansen-krone@uit.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21614415

Citation

Hansen-Krone, Ida J., et al. "Alcohol Consumption, Types of Alcoholic Beverages and Risk of Venous Thromboembolism - the Tromsø Study." Thrombosis and Haemostasis, vol. 106, no. 2, 2011, pp. 272-8.
Hansen-Krone IJ, Brækkan SK, Enga KF, et al. Alcohol consumption, types of alcoholic beverages and risk of venous thromboembolism - the Tromsø Study. Thromb Haemost. 2011;106(2):272-8.
Hansen-Krone, I. J., Brækkan, S. K., Enga, K. F., Wilsgaard, T., & Hansen, J. B. (2011). Alcohol consumption, types of alcoholic beverages and risk of venous thromboembolism - the Tromsø Study. Thrombosis and Haemostasis, 106(2), pp. 272-8. doi:10.1160/TH-11-01-0043.
Hansen-Krone IJ, et al. Alcohol Consumption, Types of Alcoholic Beverages and Risk of Venous Thromboembolism - the Tromsø Study. Thromb Haemost. 2011;106(2):272-8. PubMed PMID: 21614415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption, types of alcoholic beverages and risk of venous thromboembolism - the Tromsø Study. AU - Hansen-Krone,Ida J, AU - Brækkan,Sigrid K, AU - Enga,Kristin F, AU - Wilsgaard,Tom, AU - Hansen,John-Bjarne, Y1 - 2011/05/26/ PY - 2011/01/28/received PY - 2011/05/03/accepted PY - 2011/5/27/entrez PY - 2011/5/27/pubmed PY - 2012/1/10/medline SP - 272 EP - 8 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 106 IS - 2 N2 - Moderate alcohol consumption has been shown to protect against cardiovascular diseases. The association between alcohol consumption, especially types of alcoholic beverages, and venous thromboembolism (VTE) is less well described. The aim of this study was to investigate the impact of alcohol consumption and different alcoholic beverages on risk of VTE. Information on alcohol consumption was collected by a self-administrated questionnaire in 26,662 subjects, aged 25-97 years, who participated in the Tromsø Study, in 1994-1995. Subjects were followed through September 1, 2007 with incident VTE as the primary outcome. There were 460 incident VTE-events during a median of 12.5 years of follow-up. Total alcohol consumption was not associated with risk of incident VTE. However, subjects consuming ≥ 3 units of liquor per week had 53% increased risk of VTE compared to teetotalers in analyses adjusted for age, sex, body mass index, smoking, diabetes, cancer, previous cardiovascular disease, physical activity and higher education (HR: 1.53, 95% CI: 1.00-2.33). Contrary, subjects with a wine intake of ≥ 3 units/week had 22% reduced risk of VTE (HR: 0.78, 95% CI: 0.47-1.30), further adjustment for liquor and beer intake strengthened the protective effect of wine (HR: 0.53, 95% CI: 0.30-1.00). Frequent binge drinkers (≥ 1/week) had a 17% increased risk of VTE compared to teetotallers (HR 1.17, 95% CI: 0.66-2.09), and a 47% increased risk compared to non-binge drinkers (HR 1.47, 95% CI: 0.85-2.54). In conclusion, liquor consumption and binge drinking was associated with increased risk of VTE, whereas wine consumption was possibly associated with reduced risk of VTE. SN - 2567-689X UR - https://www.unboundmedicine.com/medline/citation/21614415/Alcohol_consumption_types_of_alcoholic_beverages_and_risk_of_venous_thromboembolism___the_Tromsø_Study_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH11-01-0043 DB - PRIME DP - Unbound Medicine ER -