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Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography.
Nat Prod Commun. 2011 May; 6(5):639-43.NP

Abstract

Echinacea angustifolia and E. purpurea are commonly used in North America for their anti-bacterial effects. Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae are traditional Chinese medicinal herbs commonly used for the treatment of complaints such as pneumonia, acute upper respiratory tract infection, and acute bronchitis. A reproducible, simple, and reliable rapid resolution liquid chromatographic (RRLC) method has been developed to analyze extracts of products formulated containing E. angustifolia, E. purpurea, Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae simultaneously in one run in less than 6 minutes. The method uses a C18-HST column, a mobile phase consisting of 0.1% aqueous phosphoric acid solution and acetonitrile, and UV detection at 327 nm and 229 nm. A stability test was performed that revealed that chlorogenic acid is more stable in acidic pH, and hence it is best to keep the extract of E. augustifolia, E. purpurea, Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae in mild acidic conditions at approximately pH 5.

Authors+Show Affiliations

Canadian Phytopharmaceuticals Corp., 12233 Riverside Way, Richmond, B.C., Canada V6W 1K8.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21615024

Citation

Ma, Jie, et al. "Simultaneous Quantification of Echinacea Species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae Combinations By Rapid Resolution Liquid Chromatography." Natural Product Communications, vol. 6, no. 5, 2011, pp. 639-43.
Ma J, Ma YC, Cai C, et al. Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. Nat Prod Commun. 2011;6(5):639-43.
Ma, J., Ma, Y. C., Cai, C., Wang, D., Hou, F. F., Luo, M., Lu, S., Gorecki, D. C., Patel, A. V., Chen, A., & Jin, P. (2011). Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. Natural Product Communications, 6(5), 639-43.
Ma J, et al. Simultaneous Quantification of Echinacea Species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae Combinations By Rapid Resolution Liquid Chromatography. Nat Prod Commun. 2011;6(5):639-43. PubMed PMID: 21615024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. AU - Ma,Jie, AU - Ma,Yuan-chun, AU - Cai,Carina, AU - Wang,Daniel, AU - Hou,Fei Fei, AU - Luo,Mai, AU - Lu,Shane, AU - Gorecki,Dariusz C, AU - Patel,Asmita V, AU - Chen,Alice, AU - Jin,Peter, PY - 2011/5/28/entrez PY - 2011/5/28/pubmed PY - 2011/6/24/medline SP - 639 EP - 43 JF - Natural product communications JO - Nat Prod Commun VL - 6 IS - 5 N2 - Echinacea angustifolia and E. purpurea are commonly used in North America for their anti-bacterial effects. Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae are traditional Chinese medicinal herbs commonly used for the treatment of complaints such as pneumonia, acute upper respiratory tract infection, and acute bronchitis. A reproducible, simple, and reliable rapid resolution liquid chromatographic (RRLC) method has been developed to analyze extracts of products formulated containing E. angustifolia, E. purpurea, Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae simultaneously in one run in less than 6 minutes. The method uses a C18-HST column, a mobile phase consisting of 0.1% aqueous phosphoric acid solution and acetonitrile, and UV detection at 327 nm and 229 nm. A stability test was performed that revealed that chlorogenic acid is more stable in acidic pH, and hence it is best to keep the extract of E. augustifolia, E. purpurea, Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae in mild acidic conditions at approximately pH 5. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/21615024/Simultaneous_quantification_of_Echinacea_species_Flos_Lonicerae_Radix_Scutellaria_and_Fructus_Forsythiae_combinations_by_rapid_resolution_liquid_chromatography_ DB - PRIME DP - Unbound Medicine ER -