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A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions.
Drug Dev Ind Pharm. 2011 Oct; 37(10):1141-9.DD

Abstract

Poor water solubility of new chemical entities (NCEs) is one of the major challenges the pharmaceutical industry currently faces. The purpose of this study was to investigate the feasibility of freeze-drying as an alternative technique to spray-drying to produce solid dispersions of poorly water-soluble drugs. Also investigated was the use of aqueous solvent mixtures in place of pure solvent for the production of solid dispersions. Aqueous solvent systems would reduce the environmental impact of pure organic solvent systems. Spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions exhibited differences in dissolution behavior. Freeze-dried dispersions exhibited faster dissolution rates than the corresponding spray-dried dispersions. Spray-dried systems prepared using both solvent systems (20% v/v and 96% v/v ethanol) displayed similar dissolution performance despite displaying differences in glass transition temperatures (T(g)) and surface areas. All dispersions showed drug/polymer interactions indicated by positive deviations in T(g) from the predicted values calculated using the Couchman-Karasz equation. Fourier transform infrared (FTIR) spectroscopic results confirmed the conversion of crystalline drug to the amorphous in the dispersions. Stability studies were preformed at 40°C and 75% relative humidity to investigate the physical stability of prepared dispersions. Recrystallization was observed after a month and the resultant dispersions were tested for their dissolution performance to compare with the dissolution performance of the dispersions prior to the stability study. The dissolution rate of the freeze-dried dispersions remained higher than both spray-dried dispersions after storage.

Authors+Show Affiliations

Pharmacodelivery Group, School of Pharmacy, University College Cork, Ireland.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21615280

Citation

Dontireddy, Rakesh, and Abina M. Crean. "A Comparative Study of Spray-dried and Freeze-dried Hydrocortisone/polyvinyl Pyrrolidone Solid Dispersions." Drug Development and Industrial Pharmacy, vol. 37, no. 10, 2011, pp. 1141-9.
Dontireddy R, Crean AM. A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions. Drug Dev Ind Pharm. 2011;37(10):1141-9.
Dontireddy, R., & Crean, A. M. (2011). A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions. Drug Development and Industrial Pharmacy, 37(10), 1141-9. https://doi.org/10.3109/03639045.2011.562213
Dontireddy R, Crean AM. A Comparative Study of Spray-dried and Freeze-dried Hydrocortisone/polyvinyl Pyrrolidone Solid Dispersions. Drug Dev Ind Pharm. 2011;37(10):1141-9. PubMed PMID: 21615280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions. AU - Dontireddy,Rakesh, AU - Crean,Abina M, Y1 - 2011/05/26/ PY - 2011/5/28/entrez PY - 2011/5/28/pubmed PY - 2011/12/21/medline SP - 1141 EP - 9 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 37 IS - 10 N2 - Poor water solubility of new chemical entities (NCEs) is one of the major challenges the pharmaceutical industry currently faces. The purpose of this study was to investigate the feasibility of freeze-drying as an alternative technique to spray-drying to produce solid dispersions of poorly water-soluble drugs. Also investigated was the use of aqueous solvent mixtures in place of pure solvent for the production of solid dispersions. Aqueous solvent systems would reduce the environmental impact of pure organic solvent systems. Spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions exhibited differences in dissolution behavior. Freeze-dried dispersions exhibited faster dissolution rates than the corresponding spray-dried dispersions. Spray-dried systems prepared using both solvent systems (20% v/v and 96% v/v ethanol) displayed similar dissolution performance despite displaying differences in glass transition temperatures (T(g)) and surface areas. All dispersions showed drug/polymer interactions indicated by positive deviations in T(g) from the predicted values calculated using the Couchman-Karasz equation. Fourier transform infrared (FTIR) spectroscopic results confirmed the conversion of crystalline drug to the amorphous in the dispersions. Stability studies were preformed at 40°C and 75% relative humidity to investigate the physical stability of prepared dispersions. Recrystallization was observed after a month and the resultant dispersions were tested for their dissolution performance to compare with the dissolution performance of the dispersions prior to the stability study. The dissolution rate of the freeze-dried dispersions remained higher than both spray-dried dispersions after storage. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/21615280/A_comparative_study_of_spray_dried_and_freeze_dried_hydrocortisone/polyvinyl_pyrrolidone_solid_dispersions_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2011.562213 DB - PRIME DP - Unbound Medicine ER -