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Acute chest syndrome: sickle cell disease.

Abstract

Acute chest syndrome (ACS) is a common complication and reason for hospital admission in patients with sickle cell disease (SCD). It is also the most common cause of death in this patient population. Most of the time, the trigger for ACS in an individual patient cannot be identified. However, although infection is the most common identifiable cause for ACS, other important triggers are vaso-occlusive crisis (VOC) and asthma. This comprehensive review will focus on the pathogenesis, clinical characteristics, complications and treatment available to manage ACS. But importantly, this review will highlight new possible etiologies, with the goal of improving oxygenation and, therefore, a reduction in sickling and lung damage in this patient population.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Division of Hematology/Oncology, Howard University, 2041 Georgia Ave. NW, Washington, DC 20060, USA. rabipaul@gmail.com

    , ,

    Source

    European journal of haematology 87:3 2011 Sep pg 191-207

    MeSH

    Acute Chest Syndrome
    Anemia, Sickle Cell
    Arterial Occlusive Diseases
    Asthma
    Humans
    Oxygen

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    21615795

    Citation

    Paul, Rabindra N., et al. "Acute Chest Syndrome: Sickle Cell Disease." European Journal of Haematology, vol. 87, no. 3, 2011, pp. 191-207.
    Paul RN, Castro OL, Aggarwal A, et al. Acute chest syndrome: sickle cell disease. Eur J Haematol. 2011;87(3):191-207.
    Paul, R. N., Castro, O. L., Aggarwal, A., & Oneal, P. A. (2011). Acute chest syndrome: sickle cell disease. European Journal of Haematology, 87(3), pp. 191-207. doi:10.1111/j.1600-0609.2011.01647.x.
    Paul RN, et al. Acute Chest Syndrome: Sickle Cell Disease. Eur J Haematol. 2011;87(3):191-207. PubMed PMID: 21615795.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Acute chest syndrome: sickle cell disease. AU - Paul,Rabindra N, AU - Castro,Oswaldo L, AU - Aggarwal,Anita, AU - Oneal,Patricia A, Y1 - 2011/07/26/ PY - 2011/5/28/entrez PY - 2011/5/28/pubmed PY - 2011/11/9/medline SP - 191 EP - 207 JF - European journal of haematology JO - Eur. J. Haematol. VL - 87 IS - 3 N2 - Acute chest syndrome (ACS) is a common complication and reason for hospital admission in patients with sickle cell disease (SCD). It is also the most common cause of death in this patient population. Most of the time, the trigger for ACS in an individual patient cannot be identified. However, although infection is the most common identifiable cause for ACS, other important triggers are vaso-occlusive crisis (VOC) and asthma. This comprehensive review will focus on the pathogenesis, clinical characteristics, complications and treatment available to manage ACS. But importantly, this review will highlight new possible etiologies, with the goal of improving oxygenation and, therefore, a reduction in sickling and lung damage in this patient population. SN - 1600-0609 UR - https://www.unboundmedicine.com/medline/citation/21615795/Acute_chest_syndrome:_sickle_cell_disease_ L2 - https://doi.org/10.1111/j.1600-0609.2011.01647.x DB - PRIME DP - Unbound Medicine ER -