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Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies.

Abstract

BACKGROUND

Previous studies of the association between intake of dairy products and colorectal cancer risk have indicated an inverse association with milk, however, the evidence for cheese or other dairy products is inconsistent.

METHODS

We conducted a systematic review and meta-analysis to clarify the shape of the dose-response relationship between dairy products and colorectal cancer risk. We searched the PubMed database for prospective studies published up to May 2010. Summary relative risks (RRs) were estimated using a random effects model.

RESULTS

Nineteen cohort studies were included. The summary RR was 0.83 (95% CI [confidence interval]: 0.78-0.88, I2=25%) per 400 g/day of total dairy products, 0.91 (95% CI: 0.85-0.94, I2=0%) per 200 g/day of milk intake and 0.96 (95% CI: 0.83-1.12, I2=28%) per 50 g/day of cheese. Inverse associations were observed in both men and women but were restricted to colon cancer. There was evidence of a nonlinear association between milk and total dairy products and colorectal cancer risk, P<0.001, and the inverse associations appeared to be the strongest at the higher range of intake.

CONCLUSION

This meta-analysis shows that milk and total dairy products, but not cheese or other dairy products, are associated with a reduction in colorectal cancer risk.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. d.aune@imperial.ac.uk

    , , , , ,

    Source

    MeSH

    Cohort Studies
    Colorectal Neoplasms
    Dairy Products
    Diet
    Female
    Humans
    Male
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    21617020

    Citation

    Aune, D, et al. "Dairy Products and Colorectal Cancer Risk: a Systematic Review and Meta-analysis of Cohort Studies." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 1, 2012, pp. 37-45.
    Aune D, Lau R, Chan DS, et al. Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol. 2012;23(1):37-45.
    Aune, D., Lau, R., Chan, D. S., Vieira, R., Greenwood, D. C., Kampman, E., & Norat, T. (2012). Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(1), pp. 37-45. doi:10.1093/annonc/mdr269.
    Aune D, et al. Dairy Products and Colorectal Cancer Risk: a Systematic Review and Meta-analysis of Cohort Studies. Ann Oncol. 2012;23(1):37-45. PubMed PMID: 21617020.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. AU - Aune,D, AU - Lau,R, AU - Chan,D S M, AU - Vieira,R, AU - Greenwood,D C, AU - Kampman,E, AU - Norat,T, Y1 - 2011/05/26/ PY - 2011/5/28/entrez PY - 2011/5/28/pubmed PY - 2012/4/12/medline SP - 37 EP - 45 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 1 N2 - BACKGROUND: Previous studies of the association between intake of dairy products and colorectal cancer risk have indicated an inverse association with milk, however, the evidence for cheese or other dairy products is inconsistent. METHODS: We conducted a systematic review and meta-analysis to clarify the shape of the dose-response relationship between dairy products and colorectal cancer risk. We searched the PubMed database for prospective studies published up to May 2010. Summary relative risks (RRs) were estimated using a random effects model. RESULTS: Nineteen cohort studies were included. The summary RR was 0.83 (95% CI [confidence interval]: 0.78-0.88, I2=25%) per 400 g/day of total dairy products, 0.91 (95% CI: 0.85-0.94, I2=0%) per 200 g/day of milk intake and 0.96 (95% CI: 0.83-1.12, I2=28%) per 50 g/day of cheese. Inverse associations were observed in both men and women but were restricted to colon cancer. There was evidence of a nonlinear association between milk and total dairy products and colorectal cancer risk, P<0.001, and the inverse associations appeared to be the strongest at the higher range of intake. CONCLUSION: This meta-analysis shows that milk and total dairy products, but not cheese or other dairy products, are associated with a reduction in colorectal cancer risk. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/21617020/full_citation L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr269 DB - PRIME DP - Unbound Medicine ER -