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Febuxostat efficacy in allopurinol-resistant tophaceous gout.
J Clin Rheumatol. 2011 Jun; 17(4):204-6.JC

Abstract

Allopurinol has been a standard hypouricemic agent for more than 40 years, but febuxostat, which is also a xanthine oxidase inhibitor, is now available. We present a case of tophaceous gout with uric acid levels that did not respond to prescription of very high doses of allopurinol or uricosuric agents. With febuxostat treatment, the patient had rapid and sustained reduction in her uric acid levels to target range. This case raises the possibility of currently unrecognized pharmacologic differences between allopurinol and febuxostat.

Authors+Show Affiliations

Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21617552

Citation

Uh, Mitchell, and Graham Reid. "Febuxostat Efficacy in Allopurinol-resistant Tophaceous Gout." Journal of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseases, vol. 17, no. 4, 2011, pp. 204-6.
Uh M, Reid G. Febuxostat efficacy in allopurinol-resistant tophaceous gout. J Clin Rheumatol. 2011;17(4):204-6.
Uh, M., & Reid, G. (2011). Febuxostat efficacy in allopurinol-resistant tophaceous gout. Journal of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseases, 17(4), 204-6. https://doi.org/10.1097/RHU.0b013e31821c0cae
Uh M, Reid G. Febuxostat Efficacy in Allopurinol-resistant Tophaceous Gout. J Clin Rheumatol. 2011;17(4):204-6. PubMed PMID: 21617552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Febuxostat efficacy in allopurinol-resistant tophaceous gout. AU - Uh,Mitchell, AU - Reid,Graham, PY - 2011/5/28/entrez PY - 2011/5/28/pubmed PY - 2011/12/16/medline SP - 204 EP - 6 JF - Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases JO - J Clin Rheumatol VL - 17 IS - 4 N2 - Allopurinol has been a standard hypouricemic agent for more than 40 years, but febuxostat, which is also a xanthine oxidase inhibitor, is now available. We present a case of tophaceous gout with uric acid levels that did not respond to prescription of very high doses of allopurinol or uricosuric agents. With febuxostat treatment, the patient had rapid and sustained reduction in her uric acid levels to target range. This case raises the possibility of currently unrecognized pharmacologic differences between allopurinol and febuxostat. SN - 1536-7355 UR - https://www.unboundmedicine.com/medline/citation/21617552/Febuxostat_efficacy_in_allopurinol_resistant_tophaceous_gout_ L2 - https://doi.org/10.1097/RHU.0b013e31821c0cae DB - PRIME DP - Unbound Medicine ER -