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Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort).
Int Angiol. 2011 Jun; 30(3):272-7.IA

Abstract

AIM

The aim of this study was to compare the change in functional signs of venous insufficiency and venous refilling time measured by mercury strain-gauge plethysmography under the effects of the combination of Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid (Cyclo 3 Fort).

METHODS

An open-label clinical trial conducted in 65 women presenting with CEAP class C2s and C3s assessment criteria. At D0 and D28, functional signs were measured on a visual analog scale (VAS), venous refilling time by mercury strain-gauge plethysmography and venous reflux by echo-Doppler method.

RESULTS

Under treatment, venous refilling time increased from 11.7±4 s to 13.8±4.4 s with Δ of 26% (P<0.0001) and the percentage of patients showing improvement of functional symptoms ≥30% was significantly correlated (P=0.04) with the percentage of patients presenting an improvement in venous refilling time ≥10%.

CONCLUSION

Improvement in subjective functional signs under treatment with Cyclo 3 Fort was correlated with objective plethysmographic parameter improvement. There-fore, this study contributes to objectively document the benefit of prescribing this venoactive drug to active women with CEAP class C2s to C3s.

Authors+Show Affiliations

Medical Evaluation, ESC CHU, Dijon, France. projet@cenbiotech.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

21617611

Citation

Allaert, F A., et al. "Correlation Between Improvement in Functional Signs and Plethysmographic Parameters During Venoactive Treatment (Cyclo 3 Fort)." International Angiology : a Journal of the International Union of Angiology, vol. 30, no. 3, 2011, pp. 272-7.
Allaert FA, Hugue C, Cazaubon M, et al. Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort). Int Angiol. 2011;30(3):272-7.
Allaert, F. A., Hugue, C., Cazaubon, M., Renaudin, J. M., Clavel, T., & Escourrou, P. (2011). Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort). International Angiology : a Journal of the International Union of Angiology, 30(3), 272-7.
Allaert FA, et al. Correlation Between Improvement in Functional Signs and Plethysmographic Parameters During Venoactive Treatment (Cyclo 3 Fort). Int Angiol. 2011;30(3):272-7. PubMed PMID: 21617611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort). AU - Allaert,F A, AU - Hugue,C, AU - Cazaubon,M, AU - Renaudin,J M, AU - Clavel,T, AU - Escourrou,P, PY - 2011/5/28/entrez PY - 2011/5/28/pubmed PY - 2011/9/17/medline SP - 272 EP - 7 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 30 IS - 3 N2 - AIM: The aim of this study was to compare the change in functional signs of venous insufficiency and venous refilling time measured by mercury strain-gauge plethysmography under the effects of the combination of Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid (Cyclo 3 Fort). METHODS: An open-label clinical trial conducted in 65 women presenting with CEAP class C2s and C3s assessment criteria. At D0 and D28, functional signs were measured on a visual analog scale (VAS), venous refilling time by mercury strain-gauge plethysmography and venous reflux by echo-Doppler method. RESULTS: Under treatment, venous refilling time increased from 11.7±4 s to 13.8±4.4 s with Δ of 26% (P<0.0001) and the percentage of patients showing improvement of functional symptoms ≥30% was significantly correlated (P=0.04) with the percentage of patients presenting an improvement in venous refilling time ≥10%. CONCLUSION: Improvement in subjective functional signs under treatment with Cyclo 3 Fort was correlated with objective plethysmographic parameter improvement. There-fore, this study contributes to objectively document the benefit of prescribing this venoactive drug to active women with CEAP class C2s to C3s. SN - 1827-1839 UR - https://www.unboundmedicine.com/medline/citation/21617611/Correlation_between_improvement_in_functional_signs_and_plethysmographic_parameters_during_venoactive_treatment__Cyclo_3_Fort__ L2 - http://www.minervamedica.it/index2.t?show=R34Y2011N03A0272 DB - PRIME DP - Unbound Medicine ER -