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Diagnostic accuracy, internal consistency, and convergent validity of the Greek version of the patient health questionnaire 9 in diagnosing depression in rheumatologic disorders.
Arthritis Care Res (Hoboken). 2011 Sep; 63(9):1313-21.AC

Abstract

OBJECTIVE

The Patient Health Questionnaire 9 (PHQ-9) was developed to screen for depressive disorders in community, primary care, and medical settings. We aimed to estimate its diagnostic accuracy, internal consistency, reliability, and convergent validity in diagnosing major depressive disorder (MDD) in Greek patients with rheumatologic disorders.

METHODS

In a 2-phase sampling design study, we recruited 475 patients with established rheumatologic disorders. One of 2 of the high scorers (PHQ-9 score ≥9, n = 85) and 1 of 3 of the low scorers (PHQ-9 score 0-8, n = 128) were interviewed using the Mini International Neuropsychiatric Interview to confirm MDD. A receiver operator characteristic curve analysis was performed to confirm the optimum threshold value. The scale's dimensional structure was tested with factor analysis, and internal consistency reliability was assessed with Cronbach's alpha. Psychological distress (Symptom Check List-90-Revised [SCL-90-R]), disability (Health Assessment Questionnaire disability index), and health-related quality of life (HRQOL; World Health Organization Quality of Life Instrument [WHOQOL-BREF]) were also assessed to test convergent validity with bivariate correlations.

RESULTS

At an optimum threshold of 10, the PHQ-9 showed a sensitivity of 81.2% and a specificity of 86.8%. The area under the curve was 0.91. The PHQ-9 presented unidimensional structure with good scale reliability (α = 0.82). The PHQ-9 score presented the greatest correlations with SCL-90-R depression (r = 0.736) and WHOQOL-BREF mental HRQOL scales (r = -0.571), and all other correlations with disability and HRQOL were in the expected direction.

CONCLUSION

At a cutoff of 10, the PHQ-9 is an accurate, reliable, and valid measure for screening for MDD among Greek rheumatologic patients.

Authors+Show Affiliations

University of Ioannina Medical School, Greece. tyfantis@cc.uoi.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

21618450

Citation

Hyphantis, Thomas, et al. "Diagnostic Accuracy, Internal Consistency, and Convergent Validity of the Greek Version of the Patient Health Questionnaire 9 in Diagnosing Depression in Rheumatologic Disorders." Arthritis Care & Research, vol. 63, no. 9, 2011, pp. 1313-21.
Hyphantis T, Kotsis K, Voulgari PV, et al. Diagnostic accuracy, internal consistency, and convergent validity of the Greek version of the patient health questionnaire 9 in diagnosing depression in rheumatologic disorders. Arthritis Care Res (Hoboken). 2011;63(9):1313-21.
Hyphantis, T., Kotsis, K., Voulgari, P. V., Tsifetaki, N., Creed, F., & Drosos, A. A. (2011). Diagnostic accuracy, internal consistency, and convergent validity of the Greek version of the patient health questionnaire 9 in diagnosing depression in rheumatologic disorders. Arthritis Care & Research, 63(9), 1313-21. https://doi.org/10.1002/acr.20505
Hyphantis T, et al. Diagnostic Accuracy, Internal Consistency, and Convergent Validity of the Greek Version of the Patient Health Questionnaire 9 in Diagnosing Depression in Rheumatologic Disorders. Arthritis Care Res (Hoboken). 2011;63(9):1313-21. PubMed PMID: 21618450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic accuracy, internal consistency, and convergent validity of the Greek version of the patient health questionnaire 9 in diagnosing depression in rheumatologic disorders. AU - Hyphantis,Thomas, AU - Kotsis,Konstantinos, AU - Voulgari,Paraskevi V, AU - Tsifetaki,Niki, AU - Creed,Francis, AU - Drosos,Alexandros A, PY - 2011/5/28/entrez PY - 2011/5/28/pubmed PY - 2011/11/1/medline SP - 1313 EP - 21 JF - Arthritis care & research JO - Arthritis Care Res (Hoboken) VL - 63 IS - 9 N2 - OBJECTIVE: The Patient Health Questionnaire 9 (PHQ-9) was developed to screen for depressive disorders in community, primary care, and medical settings. We aimed to estimate its diagnostic accuracy, internal consistency, reliability, and convergent validity in diagnosing major depressive disorder (MDD) in Greek patients with rheumatologic disorders. METHODS: In a 2-phase sampling design study, we recruited 475 patients with established rheumatologic disorders. One of 2 of the high scorers (PHQ-9 score ≥9, n = 85) and 1 of 3 of the low scorers (PHQ-9 score 0-8, n = 128) were interviewed using the Mini International Neuropsychiatric Interview to confirm MDD. A receiver operator characteristic curve analysis was performed to confirm the optimum threshold value. The scale's dimensional structure was tested with factor analysis, and internal consistency reliability was assessed with Cronbach's alpha. Psychological distress (Symptom Check List-90-Revised [SCL-90-R]), disability (Health Assessment Questionnaire disability index), and health-related quality of life (HRQOL; World Health Organization Quality of Life Instrument [WHOQOL-BREF]) were also assessed to test convergent validity with bivariate correlations. RESULTS: At an optimum threshold of 10, the PHQ-9 showed a sensitivity of 81.2% and a specificity of 86.8%. The area under the curve was 0.91. The PHQ-9 presented unidimensional structure with good scale reliability (α = 0.82). The PHQ-9 score presented the greatest correlations with SCL-90-R depression (r = 0.736) and WHOQOL-BREF mental HRQOL scales (r = -0.571), and all other correlations with disability and HRQOL were in the expected direction. CONCLUSION: At a cutoff of 10, the PHQ-9 is an accurate, reliable, and valid measure for screening for MDD among Greek rheumatologic patients. SN - 2151-4658 UR - https://www.unboundmedicine.com/medline/citation/21618450/Diagnostic_accuracy_internal_consistency_and_convergent_validity_of_the_Greek_version_of_the_patient_health_questionnaire_9_in_diagnosing_depression_in_rheumatologic_disorders_ L2 - https://doi.org/10.1002/acr.20505 DB - PRIME DP - Unbound Medicine ER -