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Acceptance Criteria for Ultratrace HPLC-Tandem Mass Spectrometry: Quantitative and Qualitative Determination of Sulfonylurea Herbicides in Soil.
Anal Chem. 1996 Oct 01; 68(19):3397-404.AC

Abstract

Eight commonly used sulfonylureas (SUs: nicosulfuron, thifensulfuron methyl, metsulfuron methyl, sulfometuron methyl, chlorsulfuron, bensulfuron methyl, tribenuron methyl, and chlorimuron methyl) and deuterium-labeled nicosulfuron (nicosulfuron-d(6)), used as an internal standard, were isolated from soil by solvent extraction and identified under quantitative and qualitative ion spray LC/MS/MS conditions using the selected reaction monitoring (SRM) mode of acquisition. The lower level of quantitation for these SUs in soil was determined at the 0.05 ppb level using a TurboIonSpray adapted LC/MS interface without a precolumn split and optimizing MS/MS tuning conditions for individual SUs. The eight SUs were qualitatively identified and quantitatively determined in soil. The standard curve for each SU was linear from 0.05 to 10 ppb. This SRM LC/MS method demonstrates high sensitivity and high specificity for these SUs in soil and shows at least a 400-fold improvement in sensitivity over previous reports. Acceptance criteria for forensically valid data are suggested for qualitative SRM LC/MS experiments. These include HPLC retention time reproducibility (±2%), at least two and preferably three precursor-product ions selected, and relative abundance criteria for selected ions (±20% absolute).

Authors+Show Affiliations

Advanced BioAnalytical Services, Inc., 15 Catherwood Road, Ithaca, New York 14850.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21619275

Citation

Li, L Y., et al. "Acceptance Criteria for Ultratrace HPLC-Tandem Mass Spectrometry: Quantitative and Qualitative Determination of Sulfonylurea Herbicides in Soil." Analytical Chemistry, vol. 68, no. 19, 1996, pp. 3397-404.
Li LY, Campbell DA, Bennett PK, et al. Acceptance Criteria for Ultratrace HPLC-Tandem Mass Spectrometry: Quantitative and Qualitative Determination of Sulfonylurea Herbicides in Soil. Anal Chem. 1996;68(19):3397-404.
Li, L. Y., Campbell, D. A., Bennett, P. K., & Henion, J. (1996). Acceptance Criteria for Ultratrace HPLC-Tandem Mass Spectrometry: Quantitative and Qualitative Determination of Sulfonylurea Herbicides in Soil. Analytical Chemistry, 68(19), 3397-404. https://doi.org/10.1021/ac960375w
Li LY, et al. Acceptance Criteria for Ultratrace HPLC-Tandem Mass Spectrometry: Quantitative and Qualitative Determination of Sulfonylurea Herbicides in Soil. Anal Chem. 1996 Oct 1;68(19):3397-404. PubMed PMID: 21619275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acceptance Criteria for Ultratrace HPLC-Tandem Mass Spectrometry: Quantitative and Qualitative Determination of Sulfonylurea Herbicides in Soil. AU - Li,L Y, AU - Campbell,D A, AU - Bennett,P K, AU - Henion,J, PY - 2011/5/31/entrez PY - 1996/10/1/pubmed PY - 1996/10/1/medline SP - 3397 EP - 404 JF - Analytical chemistry JO - Anal Chem VL - 68 IS - 19 N2 - Eight commonly used sulfonylureas (SUs: nicosulfuron, thifensulfuron methyl, metsulfuron methyl, sulfometuron methyl, chlorsulfuron, bensulfuron methyl, tribenuron methyl, and chlorimuron methyl) and deuterium-labeled nicosulfuron (nicosulfuron-d(6)), used as an internal standard, were isolated from soil by solvent extraction and identified under quantitative and qualitative ion spray LC/MS/MS conditions using the selected reaction monitoring (SRM) mode of acquisition. The lower level of quantitation for these SUs in soil was determined at the 0.05 ppb level using a TurboIonSpray adapted LC/MS interface without a precolumn split and optimizing MS/MS tuning conditions for individual SUs. The eight SUs were qualitatively identified and quantitatively determined in soil. The standard curve for each SU was linear from 0.05 to 10 ppb. This SRM LC/MS method demonstrates high sensitivity and high specificity for these SUs in soil and shows at least a 400-fold improvement in sensitivity over previous reports. Acceptance criteria for forensically valid data are suggested for qualitative SRM LC/MS experiments. These include HPLC retention time reproducibility (±2%), at least two and preferably three precursor-product ions selected, and relative abundance criteria for selected ions (±20% absolute). SN - 0003-2700 UR - https://www.unboundmedicine.com/medline/citation/21619275/Acceptance_Criteria_for_Ultratrace_HPLC_Tandem_Mass_Spectrometry:_Quantitative_and_Qualitative_Determination_of_Sulfonylurea_Herbicides_in_Soil_ L2 - https://doi.org/10.1021/ac960375w DB - PRIME DP - Unbound Medicine ER -
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