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Effect of neuropeptide Y on vasodilation mediated by calcitonin gene-related peptide (CGRP)-containing nerves in the mesenteric resistance vessel of the rat.
Jpn J Pharmacol. 1990 May; 53(1):125-8.JJ

Abstract

The role of neuropeptide Y (NPY) in the neurotransmission of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves was investigated in perfused mesenteric vascular beds of the rat with active tone. NPY (5 and 10 nM) significantly inhibited the neurogenic vasodilation induced by perivascular nerve stimulation (1-8 Hz). However, NPY had no effect on vasodilation in response to bolus infusion of rat CGRP (10 and 100 pmol). These results suggest that NPY modulates the release of CGRP from CGRP-containing nerves in mesenteric resistance vessels.

Authors+Show Affiliations

Department of Pharmacology, Miyazaki Medical College, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2161963

Citation

Nuki, C, et al. "Effect of Neuropeptide Y On Vasodilation Mediated By Calcitonin Gene-related Peptide (CGRP)-containing Nerves in the Mesenteric Resistance Vessel of the Rat." Japanese Journal of Pharmacology, vol. 53, no. 1, 1990, pp. 125-8.
Nuki C, Kawasaki H, Takasaki K. Effect of neuropeptide Y on vasodilation mediated by calcitonin gene-related peptide (CGRP)-containing nerves in the mesenteric resistance vessel of the rat. Jpn J Pharmacol. 1990;53(1):125-8.
Nuki, C., Kawasaki, H., & Takasaki, K. (1990). Effect of neuropeptide Y on vasodilation mediated by calcitonin gene-related peptide (CGRP)-containing nerves in the mesenteric resistance vessel of the rat. Japanese Journal of Pharmacology, 53(1), 125-8.
Nuki C, Kawasaki H, Takasaki K. Effect of Neuropeptide Y On Vasodilation Mediated By Calcitonin Gene-related Peptide (CGRP)-containing Nerves in the Mesenteric Resistance Vessel of the Rat. Jpn J Pharmacol. 1990;53(1):125-8. PubMed PMID: 2161963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of neuropeptide Y on vasodilation mediated by calcitonin gene-related peptide (CGRP)-containing nerves in the mesenteric resistance vessel of the rat. AU - Nuki,C, AU - Kawasaki,H, AU - Takasaki,K, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 125 EP - 8 JF - Japanese journal of pharmacology JO - Jpn J Pharmacol VL - 53 IS - 1 N2 - The role of neuropeptide Y (NPY) in the neurotransmission of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves was investigated in perfused mesenteric vascular beds of the rat with active tone. NPY (5 and 10 nM) significantly inhibited the neurogenic vasodilation induced by perivascular nerve stimulation (1-8 Hz). However, NPY had no effect on vasodilation in response to bolus infusion of rat CGRP (10 and 100 pmol). These results suggest that NPY modulates the release of CGRP from CGRP-containing nerves in mesenteric resistance vessels. SN - 0021-5198 UR - https://www.unboundmedicine.com/medline/citation/2161963/Effect_of_neuropeptide_Y_on_vasodilation_mediated_by_calcitonin_gene_related_peptide__CGRP__containing_nerves_in_the_mesenteric_resistance_vessel_of_the_rat_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/jphs1951/53.125?from=PubMed DB - PRIME DP - Unbound Medicine ER -