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Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats.
Brain Res. 2011 Jun 29; 1398:13-20.BR

Abstract

In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient temperature of 25°C. The acute hyperthermia following the higher dosages was much stronger in males than in females. After the highest dose, body temperature was even raised for several days. This effect was particularly present in males where nocturnal hyperthermia persisted the whole 4-week period of sampling. Despite the differences in the acute hyperthermic response, no significant gender differences were found in 5-HT depletion 4 weeks after MDMA (9 mg/kg) administration. A striking difference was present, however, in the concentration of the 5-HT metabolite 5-HIAA after MDMA administration. In males 5-HIAA levels decreased, whereas in females this metabolite was hardly affected, suggesting a lasting increase in 5-HT turnover in females following drug administration. When genders were matched for their acute physiological hyperthermic response by repeated injection of 9 mg/kg in female rats and 6 mg/kg in male rats, 5-HT depletion was only present in females. In this experiment with matched acute physiological responses 5-HIAA levels also decreased much stronger in males, suggesting an increased 5-HT turnover in females 4 weeks after MDMA administration. In conclusion, although male rats are clearly more susceptible for the acute as well as the lasting hyperthermic effects of MDMA than females, this is not reflected in levels of 5-HT depletion following administration of similar dosages of the drug. This may indicate that, in case of a similar thermogenic response, females have a higher 5-HT neurotoxicity following MDMA than males.

Authors+Show Affiliations

Department of Behavioral Physiology, Biological Center, University of Groningen, Haren, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21620380

Citation

Wallinga, Alinde E., et al. "Gender Differences in Hyperthermia and Regional 5-HT and 5-HIAA Depletion in the Brain Following MDMA Administration in Rats." Brain Research, vol. 1398, 2011, pp. 13-20.
Wallinga AE, Grahlmann C, Granneman RA, et al. Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats. Brain Res. 2011;1398:13-20.
Wallinga, A. E., Grahlmann, C., Granneman, R. A., Koolhaas, J. M., & Buwalda, B. (2011). Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats. Brain Research, 1398, 13-20. https://doi.org/10.1016/j.brainres.2011.04.039
Wallinga AE, et al. Gender Differences in Hyperthermia and Regional 5-HT and 5-HIAA Depletion in the Brain Following MDMA Administration in Rats. Brain Res. 2011 Jun 29;1398:13-20. PubMed PMID: 21620380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats. AU - Wallinga,Alinde E, AU - Grahlmann,Carolin, AU - Granneman,Ramon A, AU - Koolhaas,Jaap M, AU - Buwalda,Bauke, Y1 - 2011/05/04/ PY - 2010/12/01/received PY - 2011/02/21/revised PY - 2011/04/20/accepted PY - 2011/5/31/entrez PY - 2011/5/31/pubmed PY - 2012/5/5/medline SP - 13 EP - 20 JF - Brain research JO - Brain Res. VL - 1398 N2 - In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient temperature of 25°C. The acute hyperthermia following the higher dosages was much stronger in males than in females. After the highest dose, body temperature was even raised for several days. This effect was particularly present in males where nocturnal hyperthermia persisted the whole 4-week period of sampling. Despite the differences in the acute hyperthermic response, no significant gender differences were found in 5-HT depletion 4 weeks after MDMA (9 mg/kg) administration. A striking difference was present, however, in the concentration of the 5-HT metabolite 5-HIAA after MDMA administration. In males 5-HIAA levels decreased, whereas in females this metabolite was hardly affected, suggesting a lasting increase in 5-HT turnover in females following drug administration. When genders were matched for their acute physiological hyperthermic response by repeated injection of 9 mg/kg in female rats and 6 mg/kg in male rats, 5-HT depletion was only present in females. In this experiment with matched acute physiological responses 5-HIAA levels also decreased much stronger in males, suggesting an increased 5-HT turnover in females 4 weeks after MDMA administration. In conclusion, although male rats are clearly more susceptible for the acute as well as the lasting hyperthermic effects of MDMA than females, this is not reflected in levels of 5-HT depletion following administration of similar dosages of the drug. This may indicate that, in case of a similar thermogenic response, females have a higher 5-HT neurotoxicity following MDMA than males. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/21620380/Gender_differences_in_hyperthermia_and_regional_5_HT_and_5_HIAA_depletion_in_the_brain_following_MDMA_administration_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(11)00801-8 DB - PRIME DP - Unbound Medicine ER -