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Levels of household particulate matter and environmental tobacco smoke exposure in the first year of life for a cohort at risk for asthma in urban Syracuse, NY.
Environ Int 2011; 37(7):1196-205EI

Abstract

The Syracuse, NY, AUDIT (Assessment of Urban Dwellings for Indoor Toxics) study was designed to quantify asthma agent levels in the inner-city homes of a birth cohort whose mothers had a diagnosis of asthma. Risk of exposure to particulate matter (PM), particle number and tobacco smoke was assessed in 103 infants' homes. Repeat measurements were made in 44% of the homes. Infants also were examined on a quarterly basis during the first year of life to monitor their respiratory health and urine cotinine levels. Overall geometric mean (GM) values for PM(2.5) of 21.2 μg/m(3) and for PM(10) of 31.8 μg/m(3) were recorded in homes at visit 1. GM values for PM(2.5) and PM(10) in smoking homes were higher at 26.3 and 37.7 μg/m(3), while values in non-smoking homes were 12.7 and 21.2 μg/m(3) respectively. Fifty-four percent of mothers (55/103) smoked at some point in pregnancy (39% smoked throughout pregnancy). Environmental tobacco smoke (ETS) exposure occurred in 68% of homes during the infants' first year. Significant to this study was the size- and time-resolved monitoring of PM at 140 home visits and the classification of PM count data. PM number counts ranged from continuously low levels (little indoor activity) to continuously high counts (constant indoor activity), and recorded apparent instances of prolonged repeated cigarette smoking. Wheezing in the first year of life was recorded for 38% of the infants (39/103). Adjusted logistic regression modeling demonstrated that elevated levels of indoor PM(2.5) (≥ 15 μg/m(3)) were a significant risk factor for infant wheezing after controlling for infant gender, mothers' age and education level, season of home visit and presence of carpeting (OR 4.21; 95% CI 1.36-13.03; p=0.013). An elevated level of the nicotine metabolite cotinine in infant urine also was associated with infant wheezing after adjusting for infant gender, mothers' age and education level (OR 5.10; 95% CI 0.96-27.24; p=0.057). ETS exposure was pervasive in the AUDIT cohort and a risk for developing infants in this urban population.

Authors+Show Affiliations

Department of Earth and Environmental Sciences, University of Texas at Arlington, Arlington, TX 76019-0049, USA. hunt@uta.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21620473

Citation

Hunt, A, et al. "Levels of Household Particulate Matter and Environmental Tobacco Smoke Exposure in the First Year of Life for a Cohort at Risk for Asthma in Urban Syracuse, NY." Environment International, vol. 37, no. 7, 2011, pp. 1196-205.
Hunt A, Crawford JA, Rosenbaum PF, et al. Levels of household particulate matter and environmental tobacco smoke exposure in the first year of life for a cohort at risk for asthma in urban Syracuse, NY. Environ Int. 2011;37(7):1196-205.
Hunt, A., Crawford, J. A., Rosenbaum, P. F., & Abraham, J. L. (2011). Levels of household particulate matter and environmental tobacco smoke exposure in the first year of life for a cohort at risk for asthma in urban Syracuse, NY. Environment International, 37(7), pp. 1196-205. doi:10.1016/j.envint.2011.04.013.
Hunt A, et al. Levels of Household Particulate Matter and Environmental Tobacco Smoke Exposure in the First Year of Life for a Cohort at Risk for Asthma in Urban Syracuse, NY. Environ Int. 2011;37(7):1196-205. PubMed PMID: 21620473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levels of household particulate matter and environmental tobacco smoke exposure in the first year of life for a cohort at risk for asthma in urban Syracuse, NY. AU - Hunt,A, AU - Crawford,J A, AU - Rosenbaum,P F, AU - Abraham,J L, Y1 - 2011/05/28/ PY - 2010/11/25/received PY - 2011/04/21/accepted PY - 2011/5/31/entrez PY - 2011/5/31/pubmed PY - 2011/10/11/medline SP - 1196 EP - 205 JF - Environment international JO - Environ Int VL - 37 IS - 7 N2 - The Syracuse, NY, AUDIT (Assessment of Urban Dwellings for Indoor Toxics) study was designed to quantify asthma agent levels in the inner-city homes of a birth cohort whose mothers had a diagnosis of asthma. Risk of exposure to particulate matter (PM), particle number and tobacco smoke was assessed in 103 infants' homes. Repeat measurements were made in 44% of the homes. Infants also were examined on a quarterly basis during the first year of life to monitor their respiratory health and urine cotinine levels. Overall geometric mean (GM) values for PM(2.5) of 21.2 μg/m(3) and for PM(10) of 31.8 μg/m(3) were recorded in homes at visit 1. GM values for PM(2.5) and PM(10) in smoking homes were higher at 26.3 and 37.7 μg/m(3), while values in non-smoking homes were 12.7 and 21.2 μg/m(3) respectively. Fifty-four percent of mothers (55/103) smoked at some point in pregnancy (39% smoked throughout pregnancy). Environmental tobacco smoke (ETS) exposure occurred in 68% of homes during the infants' first year. Significant to this study was the size- and time-resolved monitoring of PM at 140 home visits and the classification of PM count data. PM number counts ranged from continuously low levels (little indoor activity) to continuously high counts (constant indoor activity), and recorded apparent instances of prolonged repeated cigarette smoking. Wheezing in the first year of life was recorded for 38% of the infants (39/103). Adjusted logistic regression modeling demonstrated that elevated levels of indoor PM(2.5) (≥ 15 μg/m(3)) were a significant risk factor for infant wheezing after controlling for infant gender, mothers' age and education level, season of home visit and presence of carpeting (OR 4.21; 95% CI 1.36-13.03; p=0.013). An elevated level of the nicotine metabolite cotinine in infant urine also was associated with infant wheezing after adjusting for infant gender, mothers' age and education level (OR 5.10; 95% CI 0.96-27.24; p=0.057). ETS exposure was pervasive in the AUDIT cohort and a risk for developing infants in this urban population. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/21620473/Levels_of_household_particulate_matter_and_environmental_tobacco_smoke_exposure_in_the_first_year_of_life_for_a_cohort_at_risk_for_asthma_in_urban_Syracuse_NY_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0160-4120(11)00123-1 DB - PRIME DP - Unbound Medicine ER -