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Association between vascular calcification scores on plain radiographs and fatty acid contents of erythrocyte membrane in hemodialysis patients.
J Ren Nutr. 2012 Jan; 22(1):58-66.JR

Abstract

OBJECTIVE

Vascular calcification (VC) scores determined by using simple plain radiographic films are known to be associated with coronary artery disease and mortality in patients undergoing hemodialysis (HD). Omega-3 fatty acid (FA) has been shown to reduce ectopic calcifications in an animal model, and it has also been shown that erythrocyte membrane omega-3 FA content is an independent discriminator of coronary artery disease. The present study was designed to demonstrate relations between VC scores and erythrocyte membrane FA contents in patients undergoing HD.

DESIGN

A cross-sectional study was carried out.

SETTING

The study was carried out at an outpatient hemodialysis unit at Dong-A University Hospital, Busan, Republic of Korea.

PATIENTS

A total of 31 patients undergoing HD were recruited. Patients with significant malnutrition, a short duration of dialysis (<12 months), a history of recent infection, malignancy, or liver disease were excluded.

MAIN OUTCOME MEASURES

Plain radiographic films of the feet, hands, pelvis, and lateral lumbar spine were examined and VC scores were determined using previously reported methods. Erythrocyte membrane FA contents were analyzed by gas chromatography.

RESULTS

The erythrocyte membrane contents of eicosapentaenoic acid and docosahexaenoic acid were not found to be related with VC on simple plain radiographic films. However, erythrocyte membrane contents of oleic acid and total monounsaturated FA (MUFA) were significantly higher in patients with significant VC scores. Furthermore, erythrocyte membrane contents of MUFA and oleic acid were found to be negatively associated with high-density lipoprotein cholesterol level and positively associated with triglyceride level.

CONCLUSION

Erythrocyte membrane contents of MUFA and oleic acid were found to be associated with VC scores determined using plain radiographs and with dyslipidemia in patients undergoing HD.

Authors+Show Affiliations

Department of Internal Medicine, Dong-A University, Seo-Gu, Busan, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21620727

Citation

Son, Young K., et al. "Association Between Vascular Calcification Scores On Plain Radiographs and Fatty Acid Contents of Erythrocyte Membrane in Hemodialysis Patients." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 22, no. 1, 2012, pp. 58-66.
Son YK, Lee SM, Kim SE, et al. Association between vascular calcification scores on plain radiographs and fatty acid contents of erythrocyte membrane in hemodialysis patients. J Ren Nutr. 2012;22(1):58-66.
Son, Y. K., Lee, S. M., Kim, S. E., Kim, K. H., Lee, S. Y., Bae, H. R., Han, J. Y., Park, Y., & An, W. S. (2012). Association between vascular calcification scores on plain radiographs and fatty acid contents of erythrocyte membrane in hemodialysis patients. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 22(1), 58-66. https://doi.org/10.1053/j.jrn.2011.01.023
Son YK, et al. Association Between Vascular Calcification Scores On Plain Radiographs and Fatty Acid Contents of Erythrocyte Membrane in Hemodialysis Patients. J Ren Nutr. 2012;22(1):58-66. PubMed PMID: 21620727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between vascular calcification scores on plain radiographs and fatty acid contents of erythrocyte membrane in hemodialysis patients. AU - Son,Young K, AU - Lee,Su M, AU - Kim,Seong E, AU - Kim,Ki H, AU - Lee,Seon Y, AU - Bae,Hae R, AU - Han,Jin Y, AU - Park,Yongsoon, AU - An,Won S, Y1 - 2011/05/26/ PY - 2010/12/21/received PY - 2011/01/26/revised PY - 2011/01/28/accepted PY - 2011/5/31/entrez PY - 2011/5/31/pubmed PY - 2012/5/9/medline SP - 58 EP - 66 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 22 IS - 1 N2 - OBJECTIVE: Vascular calcification (VC) scores determined by using simple plain radiographic films are known to be associated with coronary artery disease and mortality in patients undergoing hemodialysis (HD). Omega-3 fatty acid (FA) has been shown to reduce ectopic calcifications in an animal model, and it has also been shown that erythrocyte membrane omega-3 FA content is an independent discriminator of coronary artery disease. The present study was designed to demonstrate relations between VC scores and erythrocyte membrane FA contents in patients undergoing HD. DESIGN: A cross-sectional study was carried out. SETTING: The study was carried out at an outpatient hemodialysis unit at Dong-A University Hospital, Busan, Republic of Korea. PATIENTS: A total of 31 patients undergoing HD were recruited. Patients with significant malnutrition, a short duration of dialysis (<12 months), a history of recent infection, malignancy, or liver disease were excluded. MAIN OUTCOME MEASURES: Plain radiographic films of the feet, hands, pelvis, and lateral lumbar spine were examined and VC scores were determined using previously reported methods. Erythrocyte membrane FA contents were analyzed by gas chromatography. RESULTS: The erythrocyte membrane contents of eicosapentaenoic acid and docosahexaenoic acid were not found to be related with VC on simple plain radiographic films. However, erythrocyte membrane contents of oleic acid and total monounsaturated FA (MUFA) were significantly higher in patients with significant VC scores. Furthermore, erythrocyte membrane contents of MUFA and oleic acid were found to be negatively associated with high-density lipoprotein cholesterol level and positively associated with triglyceride level. CONCLUSION: Erythrocyte membrane contents of MUFA and oleic acid were found to be associated with VC scores determined using plain radiographs and with dyslipidemia in patients undergoing HD. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/21620727/Association_between_vascular_calcification_scores_on_plain_radiographs_and_fatty_acid_contents_of_erythrocyte_membrane_in_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(11)00045-8 DB - PRIME DP - Unbound Medicine ER -