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Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate.
Eur J Pharm Sci. 2011 Jul 17; 43(4):325-33.EJ

Abstract

The purpose was to employ a new finite dilution approach to determine total surface energy distributions of mechanofused powders by inverse gas chromatography (IGC) to contribute to the understanding of their improved flow properties and to help optimise the magnesium stearate (MgSt) coating. Pharmatose 450M was mechanofused with between 0.1 and 8% (w/w) of MgSt. The non-polar, polar and total surface energies and work of cohesion at infinite dilution and the energy distributions at finite dilution were constructed using IGC. Brunauer-Emmet-Teller (BET) surface area and particle morphology were determined by IGC and scanning electron microscope, respectively. Surface energies determined at finite dilution appeared more consistent with the observed flow behaviour of mechanofused powders than comparative surface energy determination at infinite dilution. Polar and total surface energy distributions together with BET surface area measurements were the lowest when lactose was mechanofused with 1-2% MgSt (w/w). In conclusion, the surface energy distribution profiles measured at finite dilution were argued to be more informative and useful in reporting the surface energy changes during mechanofusion, optimising MgSt concentration in the mechanofusion process, and the flow behaviour of mechanofused powders.

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Authors+Show Affiliations

Das SC
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381, Royal Parade, Parkville, Melbourne, Victoria 3021, Australia. Shyamal.das@monash.edu
Zhou Q
No affiliation info available
Morton DA
No affiliation info available
Larson I
No affiliation info available
Stewart PJ
No affiliation info available

MeSH

Chromatography, GasExcipientsLactosePowdersStearic AcidsSurface Properties

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21621612

Citation

Das, Shyamal C., et al. "Use of Surface Energy Distributions By Inverse Gas Chromatography to Understand Mechanofusion Processing and Functionality of Lactose Coated With Magnesium Stearate." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 43, no. 4, 2011, pp. 325-33.
Das SC, Zhou Q, Morton DA, et al. Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. Eur J Pharm Sci. 2011;43(4):325-33.
Das, S. C., Zhou, Q., Morton, D. A., Larson, I., & Stewart, P. J. (2011). Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 43(4), 325-33. https://doi.org/10.1016/j.ejps.2011.05.012
Das SC, et al. Use of Surface Energy Distributions By Inverse Gas Chromatography to Understand Mechanofusion Processing and Functionality of Lactose Coated With Magnesium Stearate. Eur J Pharm Sci. 2011 Jul 17;43(4):325-33. PubMed PMID: 21621612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. AU - Das,Shyamal C, AU - Zhou,Qi, AU - Morton,David A V, AU - Larson,Ian, AU - Stewart,Peter J, Y1 - 2011/05/20/ PY - 2011/03/07/received PY - 2011/05/02/revised PY - 2011/05/14/accepted PY - 2011/5/31/entrez PY - 2011/5/31/pubmed PY - 2011/11/8/medline SP - 325 EP - 33 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 43 IS - 4 N2 - The purpose was to employ a new finite dilution approach to determine total surface energy distributions of mechanofused powders by inverse gas chromatography (IGC) to contribute to the understanding of their improved flow properties and to help optimise the magnesium stearate (MgSt) coating. Pharmatose 450M was mechanofused with between 0.1 and 8% (w/w) of MgSt. The non-polar, polar and total surface energies and work of cohesion at infinite dilution and the energy distributions at finite dilution were constructed using IGC. Brunauer-Emmet-Teller (BET) surface area and particle morphology were determined by IGC and scanning electron microscope, respectively. Surface energies determined at finite dilution appeared more consistent with the observed flow behaviour of mechanofused powders than comparative surface energy determination at infinite dilution. Polar and total surface energy distributions together with BET surface area measurements were the lowest when lactose was mechanofused with 1-2% MgSt (w/w). In conclusion, the surface energy distribution profiles measured at finite dilution were argued to be more informative and useful in reporting the surface energy changes during mechanofusion, optimising MgSt concentration in the mechanofusion process, and the flow behaviour of mechanofused powders. SN - 1879-0720 UR - https://www.unboundmedicine.com/medline/citation/21621612/Use_of_surface_energy_distributions_by_inverse_gas_chromatography_to_understand_mechanofusion_processing_and_functionality_of_lactose_coated_with_magnesium_stearate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-0987(11)00164-3 DB - PRIME DP - Unbound Medicine ER -