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Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; the HELENA study.
Int J Pediatr Obes. 2011 Aug; 6(3-4):253-60.IJ

Abstract

OBJECTIVE

To examine the independent association of total and central body fat and cardiorespiratory fitness with markers of insulin resistance after controlling for several potential confounders in European adolescents participating in the HELENA-CSS (Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional) study.

METHODS

We conducted a cross sectional study (the HELENA-CSS) which comprised 1053 (12.5-17.5 years) adolescents from 10 European cities. Weight, height, waist circumference and skinfold thickness were measured, and body mass index (BMI) was calculated. Cardiorespiratory fitness was measured by the 20-m shuttle run test. Markers of insulin resistance were fasting insulin and glucose, and homeostasis model assessment (HOMA).

RESULTS

HOMA and insulin were positively associated with BMI, skinfolds and waist circumference after controlling for center, age, pubertal status and cardiorespiratory fitness (all P ? 0.01). HOMA and insulin were negatively associated with cardiorespiratory fitness in adolescents with moderate to high levels of total and central body fat (all P ? 0.01).

CONCLUSIONS

HOMA and insulin were associated with total and central body fat in European adolescents. Moreover, cardiorespiratory fitness explained a part of the HOMA and insulin variance in those adolescents with moderate to high levels of total and central body fat, and also, to some extent, in those with low to middle fat mass.

Authors+Show Affiliations

Department of Medical Physiology, School of Medicine, University of Granada , Spain. davidjimenez@ugr.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21623681

Citation

Jiménez-Pavón, David, et al. "Fitness and Fatness Are Independently Associated With Markers of Insulin Resistance in European Adolescents; the HELENA Study." International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity, vol. 6, no. 3-4, 2011, pp. 253-60.
Jiménez-Pavón D, Castillo MJ, Moreno LA, et al. Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; the HELENA study. Int J Pediatr Obes. 2011;6(3-4):253-60.
Jiménez-Pavón, D., Castillo, M. J., Moreno, L. A., Kafatos, A., Manios, Y., Kondaki, K., Béghin, L., Zaccaria, M., de Henauw, S., Widhalm, K., Moln R, D. N., Sjöström, M., González-Gross, M., & Ruiz, J. R. (2011). Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; the HELENA study. International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity, 6(3-4), 253-60. https://doi.org/10.3109/17477166.2011.575158
Jiménez-Pavón D, et al. Fitness and Fatness Are Independently Associated With Markers of Insulin Resistance in European Adolescents; the HELENA Study. Int J Pediatr Obes. 2011;6(3-4):253-60. PubMed PMID: 21623681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; the HELENA study. AU - Jiménez-Pavón,David, AU - Castillo,Manuel J, AU - Moreno,Luis A, AU - Kafatos,Anthony, AU - Manios,Yannis, AU - Kondaki,Katerine, AU - Béghin,Laurent, AU - Zaccaria,Maria, AU - de Henauw,Stefaan, AU - Widhalm,Kurt, AU - Moln R,D Nes, AU - Sjöström,Michael, AU - González-Gross,Marcela, AU - Ruiz,Jonatan R, AU - ,, Y1 - 2011/05/31/ PY - 2011/6/1/entrez PY - 2011/6/1/pubmed PY - 2011/11/15/medline SP - 253 EP - 60 JF - International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity JO - Int J Pediatr Obes VL - 6 IS - 3-4 N2 - OBJECTIVE: To examine the independent association of total and central body fat and cardiorespiratory fitness with markers of insulin resistance after controlling for several potential confounders in European adolescents participating in the HELENA-CSS (Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional) study. METHODS: We conducted a cross sectional study (the HELENA-CSS) which comprised 1053 (12.5-17.5 years) adolescents from 10 European cities. Weight, height, waist circumference and skinfold thickness were measured, and body mass index (BMI) was calculated. Cardiorespiratory fitness was measured by the 20-m shuttle run test. Markers of insulin resistance were fasting insulin and glucose, and homeostasis model assessment (HOMA). RESULTS: HOMA and insulin were positively associated with BMI, skinfolds and waist circumference after controlling for center, age, pubertal status and cardiorespiratory fitness (all P ? 0.01). HOMA and insulin were negatively associated with cardiorespiratory fitness in adolescents with moderate to high levels of total and central body fat (all P ? 0.01). CONCLUSIONS: HOMA and insulin were associated with total and central body fat in European adolescents. Moreover, cardiorespiratory fitness explained a part of the HOMA and insulin variance in those adolescents with moderate to high levels of total and central body fat, and also, to some extent, in those with low to middle fat mass. SN - 1747-7174 UR - https://www.unboundmedicine.com/medline/citation/21623681/Fitness_and_fatness_are_independently_associated_with_markers_of_insulin_resistance_in_European_adolescents L2 - https://doi.org/10.3109/17477166.2011.575158 DB - PRIME DP - Unbound Medicine ER -