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Persistence of antibodies in 4-8 year old Austrian children after vaccination with hexavalent DTaP-HBV-IPV/Hib and MMR vaccines.
Vaccine. 2011 Jul 18; 29(32):5130-6.V

Abstract

To determine the proficiency of the Austrian childhood vaccination schedule to induce long lasting seroprotection against vaccine preventable diseases a seroepidemiological study in 348 children between four and eight years of age was conducted. Antibodies against diphtheria, tetanus, pertussis, hepatitis B, measles, mumps and rubella antigens were assessed in children, who had been vaccinated with hexavalent DTaP-HBV-IPV/Hib vaccines at three, four, five months and in the second year of life and/or MMR vaccines in the second year of life at least once, but mostly twice. High seroprotection rates (SPRs) were detected for tetanus (96%) and measles (90%). SPRs regarding diphtheria and mumps were 81% and 72%, respectively. Rubella-SPRs were 68% in females and 58% in males. Hepatitis B-antibody levels ≥10 mIU/mL were present in 52%; antibodies against pertussis were detected in 27% of the children. SPRs for measles and rubella depended on the interval since last vaccination; mumps-antibodies were significantly lower after one MMR-vaccination only. Antibodies against diphtheria, tetanus and pertussis depended on the interval since last vaccination while HBs-antibodies did not. The low levels of antibodies 1-7 years after vaccination against pertussis, rubella and mumps after only one vaccination should be considered when recommending new vaccination schedules.

Authors+Show Affiliations

Department of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21624412

Citation

Paulke-Korinek, Maria, et al. "Persistence of Antibodies in 4-8 Year Old Austrian Children After Vaccination With Hexavalent DTaP-HBV-IPV/Hib and MMR Vaccines." Vaccine, vol. 29, no. 32, 2011, pp. 5130-6.
Paulke-Korinek M, Fischmeister G, Grac A, et al. Persistence of antibodies in 4-8 year old Austrian children after vaccination with hexavalent DTaP-HBV-IPV/Hib and MMR vaccines. Vaccine. 2011;29(32):5130-6.
Paulke-Korinek, M., Fischmeister, G., Grac, A., Rendi-Wagner, P., Kundi, M., Mohsenzadeh-Rabbani, A., Moritz, K., Fenninger, B., Jarisch, R., Jasinska, J., Holzmann, H., Wiedermann, U., & Kollaritsch, H. (2011). Persistence of antibodies in 4-8 year old Austrian children after vaccination with hexavalent DTaP-HBV-IPV/Hib and MMR vaccines. Vaccine, 29(32), 5130-6. https://doi.org/10.1016/j.vaccine.2011.05.046
Paulke-Korinek M, et al. Persistence of Antibodies in 4-8 Year Old Austrian Children After Vaccination With Hexavalent DTaP-HBV-IPV/Hib and MMR Vaccines. Vaccine. 2011 Jul 18;29(32):5130-6. PubMed PMID: 21624412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistence of antibodies in 4-8 year old Austrian children after vaccination with hexavalent DTaP-HBV-IPV/Hib and MMR vaccines. AU - Paulke-Korinek,Maria, AU - Fischmeister,Gustav, AU - Grac,Ana, AU - Rendi-Wagner,Pamela, AU - Kundi,Michael, AU - Mohsenzadeh-Rabbani,Afsaneh, AU - Moritz,Katharina, AU - Fenninger,Beate, AU - Jarisch,Reinhart, AU - Jasinska,Joanna, AU - Holzmann,Heidemarie, AU - Wiedermann,Ursula, AU - Kollaritsch,Herwig, Y1 - 2011/05/30/ PY - 2010/09/04/received PY - 2011/05/08/revised PY - 2011/05/14/accepted PY - 2011/6/1/entrez PY - 2011/6/1/pubmed PY - 2012/1/19/medline SP - 5130 EP - 6 JF - Vaccine JO - Vaccine VL - 29 IS - 32 N2 - To determine the proficiency of the Austrian childhood vaccination schedule to induce long lasting seroprotection against vaccine preventable diseases a seroepidemiological study in 348 children between four and eight years of age was conducted. Antibodies against diphtheria, tetanus, pertussis, hepatitis B, measles, mumps and rubella antigens were assessed in children, who had been vaccinated with hexavalent DTaP-HBV-IPV/Hib vaccines at three, four, five months and in the second year of life and/or MMR vaccines in the second year of life at least once, but mostly twice. High seroprotection rates (SPRs) were detected for tetanus (96%) and measles (90%). SPRs regarding diphtheria and mumps were 81% and 72%, respectively. Rubella-SPRs were 68% in females and 58% in males. Hepatitis B-antibody levels ≥10 mIU/mL were present in 52%; antibodies against pertussis were detected in 27% of the children. SPRs for measles and rubella depended on the interval since last vaccination; mumps-antibodies were significantly lower after one MMR-vaccination only. Antibodies against diphtheria, tetanus and pertussis depended on the interval since last vaccination while HBs-antibodies did not. The low levels of antibodies 1-7 years after vaccination against pertussis, rubella and mumps after only one vaccination should be considered when recommending new vaccination schedules. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21624412/Persistence_of_antibodies_in_4_8_year_old_Austrian_children_after_vaccination_with_hexavalent_DTaP_HBV_IPV/Hib_and_MMR_vaccines_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)00766-3 DB - PRIME DP - Unbound Medicine ER -