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Pharmacokinetic and chemoprevention studies on tea in humans.

Abstract

Green tea and its major polyphenols constituents, tea catechins, have been shown to have many health benefits including cancer prevention. Tea catechins and tea catechin metabolites/catabolites are bioavailable in the systemic circulation after oral intake of green tea or green tea catechins. The metabolites/catabolites identified in humans include glucuronide/sulfate conjugates, methylated tea catechin conjugates, and microflora-mediated ring fission products and phenolic acid catabolites. Plasma levels of unchanged tea catechins in humans are mostly in the sub-μM or nM concentration range, which is much lower than the effective concentrations determined in most in vitro studies. However, some of the catechin metabolites/catabolites are present in the systemic circulation at levels much higher than those of the parent catechins. The contribution of catechin derived metabolites/catabolites to the biological effects associated with green tea is yet to be defined. A limited number of chemoprevention trials of green tea or green tea catechins have been conducted to date and have observed potential preventive activity for oral, prostate, and colorectal cancer. Emerging data from multiple ongoing intervention trials will further contribute to defining the cancer preventive activity of green tea or green tea catechins.

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  • Authors+Show Affiliations

    ,

    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, United States. schow@azcc.arizona.edu

    Source

    Pharmacological research 64:2 2011 Aug pg 105-12

    MeSH

    Animals
    Anticarcinogenic Agents
    Catechin
    Flavonoids
    Humans
    Neoplasms
    Phenols
    Plant Extracts
    Polyphenols
    Tea

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    21624470

    Citation

    Chow, H-H Sherry, and Iman A. Hakim. "Pharmacokinetic and Chemoprevention Studies On Tea in Humans." Pharmacological Research, vol. 64, no. 2, 2011, pp. 105-12.
    Chow HH, Hakim IA. Pharmacokinetic and chemoprevention studies on tea in humans. Pharmacol Res. 2011;64(2):105-12.
    Chow, H. H., & Hakim, I. A. (2011). Pharmacokinetic and chemoprevention studies on tea in humans. Pharmacological Research, 64(2), pp. 105-12. doi:10.1016/j.phrs.2011.05.007.
    Chow HH, Hakim IA. Pharmacokinetic and Chemoprevention Studies On Tea in Humans. Pharmacol Res. 2011;64(2):105-12. PubMed PMID: 21624470.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pharmacokinetic and chemoprevention studies on tea in humans. AU - Chow,H-H Sherry, AU - Hakim,Iman A, Y1 - 2011/05/20/ PY - 2010/12/17/received PY - 2011/05/10/revised PY - 2011/05/12/accepted PY - 2011/6/1/entrez PY - 2011/6/1/pubmed PY - 2011/11/10/medline SP - 105 EP - 12 JF - Pharmacological research JO - Pharmacol. Res. VL - 64 IS - 2 N2 - Green tea and its major polyphenols constituents, tea catechins, have been shown to have many health benefits including cancer prevention. Tea catechins and tea catechin metabolites/catabolites are bioavailable in the systemic circulation after oral intake of green tea or green tea catechins. The metabolites/catabolites identified in humans include glucuronide/sulfate conjugates, methylated tea catechin conjugates, and microflora-mediated ring fission products and phenolic acid catabolites. Plasma levels of unchanged tea catechins in humans are mostly in the sub-μM or nM concentration range, which is much lower than the effective concentrations determined in most in vitro studies. However, some of the catechin metabolites/catabolites are present in the systemic circulation at levels much higher than those of the parent catechins. The contribution of catechin derived metabolites/catabolites to the biological effects associated with green tea is yet to be defined. A limited number of chemoprevention trials of green tea or green tea catechins have been conducted to date and have observed potential preventive activity for oral, prostate, and colorectal cancer. Emerging data from multiple ongoing intervention trials will further contribute to defining the cancer preventive activity of green tea or green tea catechins. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/21624470/Pharmacokinetic_and_chemoprevention_studies_on_tea_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(11)00143-5 DB - PRIME DP - Unbound Medicine ER -