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Increased risk of cataract among 28,000 patients with celiac disease.

Abstract

Vitamin deficiencies are prevalent in celiac disease (CD) and are associated with cataract formation, but it is unknown whether persons with CD are at increased risk of cataract. The authors' objective in this population-based cohort study was to determine the risk of cataract among persons with biopsy-verified CD. Data on CD were collected from reports on small intestinal biopsies performed between July 1969 and February 2008 in the 28 regional pathology departments in Sweden. The authors identified 28,756 persons with CD (villous atrophy, Marsh pathology stage 3). For each person with CD, Statistics Sweden selected up to 5 controls matched for age and sex from the Total Population Register. Data on cataract were obtained from the Swedish National Hospital Discharge Register and the National Day-Surgery Register. Cox regression analysis was used to estimate the risk of cataract. During a median follow-up period of 9 years, the authors identified 1,159 cataracts among persons with CD (909 were expected) (hazard ratio = 1.28, 95% confidence interval: 1.19, 1.36). The absolute risk of cataract was 397/100,000 person-years in CD, with an excess risk of 86/100,000 person-years. In conclusion, this study found an increased risk of developing cataract in patients with CD.

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  • Authors+Show Affiliations

    ,

    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Solna, Sweden. kaziwe.mollazadegan@live.se

    , ,

    Source

    American journal of epidemiology 174:2 2011 Jul 15 pg 195-202

    MeSH

    Adolescent
    Adult
    Cataract
    Celiac Disease
    Child
    Child, Preschool
    Female
    Humans
    Infant
    Infant, Newborn
    Male
    Middle Aged
    Risk Factors
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21624959

    Citation

    Mollazadegan, Kaziwe, et al. "Increased Risk of Cataract Among 28,000 Patients With Celiac Disease." American Journal of Epidemiology, vol. 174, no. 2, 2011, pp. 195-202.
    Mollazadegan K, Kugelberg M, Lindblad BE, et al. Increased risk of cataract among 28,000 patients with celiac disease. Am J Epidemiol. 2011;174(2):195-202.
    Mollazadegan, K., Kugelberg, M., Lindblad, B. E., & Ludvigsson, J. F. (2011). Increased risk of cataract among 28,000 patients with celiac disease. American Journal of Epidemiology, 174(2), pp. 195-202. doi:10.1093/aje/kwr069.
    Mollazadegan K, et al. Increased Risk of Cataract Among 28,000 Patients With Celiac Disease. Am J Epidemiol. 2011 Jul 15;174(2):195-202. PubMed PMID: 21624959.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Increased risk of cataract among 28,000 patients with celiac disease. AU - Mollazadegan,Kaziwe, AU - Kugelberg,Maria, AU - Lindblad,Birgitta Ejdervik, AU - Ludvigsson,Jonas F, Y1 - 2011/05/30/ PY - 2011/6/1/entrez PY - 2011/6/1/pubmed PY - 2011/10/1/medline SP - 195 EP - 202 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 174 IS - 2 N2 - Vitamin deficiencies are prevalent in celiac disease (CD) and are associated with cataract formation, but it is unknown whether persons with CD are at increased risk of cataract. The authors' objective in this population-based cohort study was to determine the risk of cataract among persons with biopsy-verified CD. Data on CD were collected from reports on small intestinal biopsies performed between July 1969 and February 2008 in the 28 regional pathology departments in Sweden. The authors identified 28,756 persons with CD (villous atrophy, Marsh pathology stage 3). For each person with CD, Statistics Sweden selected up to 5 controls matched for age and sex from the Total Population Register. Data on cataract were obtained from the Swedish National Hospital Discharge Register and the National Day-Surgery Register. Cox regression analysis was used to estimate the risk of cataract. During a median follow-up period of 9 years, the authors identified 1,159 cataracts among persons with CD (909 were expected) (hazard ratio = 1.28, 95% confidence interval: 1.19, 1.36). The absolute risk of cataract was 397/100,000 person-years in CD, with an excess risk of 86/100,000 person-years. In conclusion, this study found an increased risk of developing cataract in patients with CD. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/21624959/Increased_risk_of_cataract_among_28000_patients_with_celiac_disease_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwr069 DB - PRIME DP - Unbound Medicine ER -