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Correlation of routine examinations for the diagnosis of house dust mite allergic rhinitis.

Abstract

OBJECTIVE

To evaluate the correlation between the routine diagnostic tests for house dust mite (HDM) sensitization in Chinese allergic rhinitis (AR) patients, including the skin prick test (SPT), serum HDM-specific immunoglobulin E (sIgE) and nasal smear eosinophilia.

METHODS

The ImmunoCAP assay was employed to detect serum total IgE and sIgE. The SPT and nasal smear eosinophil counts were performed using standard procedures.

RESULTS

Of 82 subjects with HDM-related symptoms and positive SPT results, 55 individuals showed an sIgE level equal to or greater than CAP class 1 for both Dermatophagoides pteronyssinus (Der p) and D. farinae (Der f), and 62 individuals demonstrated positive eosinophils in nasal smears. sIgE of Der p and Der f presented a linear correlation, and the level of serum HDM-sIgE was also positively correlated with total IgE. An increasing sIgE level was correlated with higher SPT grades in both Der p and Der f. Meanwhile, the correlation coefficient exhibited an increase in value with aging, and the 31- to 40-year age group demonstrated the highest value for both Der p and Der f.

CONCLUSION

The positive correlation between SPT and sIgE reaction to HDM varied according to the age of patients with AR.

Authors+Show Affiliations

Key Laboratory of Otolaryngology-Head and Neck Surgery (Ministry of Education of China), Beijing Institute of Otolaryngology, Beijing, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21625194

Citation

Zhang, Yuan, et al. "Correlation of Routine Examinations for the Diagnosis of House Dust Mite Allergic Rhinitis." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 73, no. 4, 2011, pp. 182-8.
Zhang Y, Liu C, Han D, et al. Correlation of routine examinations for the diagnosis of house dust mite allergic rhinitis. ORL J Otorhinolaryngol Relat Spec. 2011;73(4):182-8.
Zhang, Y., Liu, C., Han, D., & Zhang, L. (2011). Correlation of routine examinations for the diagnosis of house dust mite allergic rhinitis. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 73(4), pp. 182-8. doi:10.1159/000328344.
Zhang Y, et al. Correlation of Routine Examinations for the Diagnosis of House Dust Mite Allergic Rhinitis. ORL J Otorhinolaryngol Relat Spec. 2011;73(4):182-8. PubMed PMID: 21625194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of routine examinations for the diagnosis of house dust mite allergic rhinitis. AU - Zhang,Yuan, AU - Liu,Chengyao, AU - Han,Demin, AU - Zhang,Luo, Y1 - 2011/05/27/ PY - 2011/01/26/received PY - 2011/04/05/accepted PY - 2011/6/1/entrez PY - 2011/6/1/pubmed PY - 2011/12/16/medline SP - 182 EP - 8 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J. Otorhinolaryngol. Relat. Spec. VL - 73 IS - 4 N2 - OBJECTIVE: To evaluate the correlation between the routine diagnostic tests for house dust mite (HDM) sensitization in Chinese allergic rhinitis (AR) patients, including the skin prick test (SPT), serum HDM-specific immunoglobulin E (sIgE) and nasal smear eosinophilia. METHODS: The ImmunoCAP assay was employed to detect serum total IgE and sIgE. The SPT and nasal smear eosinophil counts were performed using standard procedures. RESULTS: Of 82 subjects with HDM-related symptoms and positive SPT results, 55 individuals showed an sIgE level equal to or greater than CAP class 1 for both Dermatophagoides pteronyssinus (Der p) and D. farinae (Der f), and 62 individuals demonstrated positive eosinophils in nasal smears. sIgE of Der p and Der f presented a linear correlation, and the level of serum HDM-sIgE was also positively correlated with total IgE. An increasing sIgE level was correlated with higher SPT grades in both Der p and Der f. Meanwhile, the correlation coefficient exhibited an increase in value with aging, and the 31- to 40-year age group demonstrated the highest value for both Der p and Der f. CONCLUSION: The positive correlation between SPT and sIgE reaction to HDM varied according to the age of patients with AR. SN - 1423-0275 UR - https://www.unboundmedicine.com/medline/citation/21625194/Correlation_of_routine_examinations_for_the_diagnosis_of_house_dust_mite_allergic_rhinitis_ L2 - https://www.karger.com?DOI=10.1159/000328344 DB - PRIME DP - Unbound Medicine ER -