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Reproducibility of coronary plaque detection and characterization using low radiation dose coronary computed tomographic angiography in patients with intermediate likelihood of coronary artery disease (ReSCAN study).
Int J Cardiovasc Imaging. 2012 Apr; 28(4):889-99.IJ

Abstract

The purpose of this study is to evaluate the interscan, interobserver and intraobserver agreement for coronary plaque detection, and characterization using low radiation dose high-pitch spiral acquisition coronary CT angiography (CTA). Two experienced observers independently evaluated coronary CTA datasets from 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days. Mean (±SD) estimated radiation exposure was 1.5 ± 0.2 mSv per scan. Observers recorded the presence and characterization of coronary plaques as non-calcified or calcified. A "segment involvement score" (SIS) was computed by summing the numbers of segments with any coronary plaque per patient. Reproducibility was assessed using kappa (κ) statistics, paired t test and Bland-Altman analyses. Interscan, interobserver, and intraobserver agreement (κ-values) for detection of any or calcified plaques were 83-94% (κ-values 0.57-0.85), and 67-84% (0.31-0.67) for non-calcified plaques on a patient level. No significant difference was observed in mean interscan or interobserver SIS. Mean (95% CI) intraobserver SIS difference was -0.88 (-1.25; -0.51), P < 0.001, with limits of agreement from -4.7 to 2.9. Low radiation dose high-pitch coronary CTA permits detection of any or calcified plaques with high interscan, interobserver, intraobserver agreement. However, variability for the detection of non-calcified plaque is substantial.

Authors+Show Affiliations

Department of Cardiology, Lillebealt Hospital-Vejle, Kabbeltoft 25, 7100, Vejle, Denmark. kristianovrehus@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21626043

Citation

Øvrehus, Kristian Altern, et al. "Reproducibility of Coronary Plaque Detection and Characterization Using Low Radiation Dose Coronary Computed Tomographic Angiography in Patients With Intermediate Likelihood of Coronary Artery Disease (ReSCAN Study)." The International Journal of Cardiovascular Imaging, vol. 28, no. 4, 2012, pp. 889-99.
Øvrehus KA, Marwan M, Bøtker HE, et al. Reproducibility of coronary plaque detection and characterization using low radiation dose coronary computed tomographic angiography in patients with intermediate likelihood of coronary artery disease (ReSCAN study). Int J Cardiovasc Imaging. 2012;28(4):889-99.
Øvrehus, K. A., Marwan, M., Bøtker, H. E., Achenbach, S., & Nørgaard, B. L. (2012). Reproducibility of coronary plaque detection and characterization using low radiation dose coronary computed tomographic angiography in patients with intermediate likelihood of coronary artery disease (ReSCAN study). The International Journal of Cardiovascular Imaging, 28(4), 889-99. https://doi.org/10.1007/s10554-011-9895-1
Øvrehus KA, et al. Reproducibility of Coronary Plaque Detection and Characterization Using Low Radiation Dose Coronary Computed Tomographic Angiography in Patients With Intermediate Likelihood of Coronary Artery Disease (ReSCAN Study). Int J Cardiovasc Imaging. 2012;28(4):889-99. PubMed PMID: 21626043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproducibility of coronary plaque detection and characterization using low radiation dose coronary computed tomographic angiography in patients with intermediate likelihood of coronary artery disease (ReSCAN study). AU - Øvrehus,Kristian Altern, AU - Marwan,Mohamed, AU - Bøtker,Hans Erik, AU - Achenbach,Stephan, AU - Nørgaard,Bjarne Linde, Y1 - 2011/05/29/ PY - 2011/03/17/received PY - 2011/05/19/accepted PY - 2011/6/1/entrez PY - 2011/6/1/pubmed PY - 2012/9/20/medline SP - 889 EP - 99 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 28 IS - 4 N2 - The purpose of this study is to evaluate the interscan, interobserver and intraobserver agreement for coronary plaque detection, and characterization using low radiation dose high-pitch spiral acquisition coronary CT angiography (CTA). Two experienced observers independently evaluated coronary CTA datasets from 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days. Mean (±SD) estimated radiation exposure was 1.5 ± 0.2 mSv per scan. Observers recorded the presence and characterization of coronary plaques as non-calcified or calcified. A "segment involvement score" (SIS) was computed by summing the numbers of segments with any coronary plaque per patient. Reproducibility was assessed using kappa (κ) statistics, paired t test and Bland-Altman analyses. Interscan, interobserver, and intraobserver agreement (κ-values) for detection of any or calcified plaques were 83-94% (κ-values 0.57-0.85), and 67-84% (0.31-0.67) for non-calcified plaques on a patient level. No significant difference was observed in mean interscan or interobserver SIS. Mean (95% CI) intraobserver SIS difference was -0.88 (-1.25; -0.51), P < 0.001, with limits of agreement from -4.7 to 2.9. Low radiation dose high-pitch coronary CTA permits detection of any or calcified plaques with high interscan, interobserver, intraobserver agreement. However, variability for the detection of non-calcified plaque is substantial. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/21626043/Reproducibility_of_coronary_plaque_detection_and_characterization_using_low_radiation_dose_coronary_computed_tomographic_angiography_in_patients_with_intermediate_likelihood_of_coronary_artery_disease__ReSCAN_study__ L2 - https://doi.org/10.1007/s10554-011-9895-1 DB - PRIME DP - Unbound Medicine ER -