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Effects of extracorporeal shock wave therapy and polysulfated glycosaminoglycan treatment on subchondral bone, serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis.
Am J Vet Res. 2011 Jun; 72(6):772-9.AJ

Abstract

OBJECTIVE

To evaluate effects of extracorporeal shock wave therapy (ESWT) and polysulfated glycosaminoglycan treatment (PSGAGT) on subchondral bone (SCB), serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis.

ANIMALS

24 healthy 2- to 3-year-old horses.

PROCEDURES

An osteochondral fragment was created on the distal aspect of the radial carpal bone in 1 middle carpal joint of each horse. Horses were randomly allocated to receive local application of ESWT (days 14 and 28; n = 8), PSGAGT (IM, q 4 d for 28 days; 8), or a sham ESWT probe (placebo; days 14 and 28; 8). Serum biomarkers were measured every 7 days, and synovial fluid biomarkers were measured every 14 days. Bone density was measured by use of computed tomography on days 0 and 70, and microdamage and bone formation variables were compared among groups at the end of the study (day 70).

RESULTS

There was no significant effect of ESWT or PSGAGT on any bone variable. Serum osteocalcin concentration was significantly greater in horses that received ESWT, compared with placebo-treated horses, and serum concentration of the C-terminal telopeptide of type I collagen was significantly higher in horses that received ESWT, compared with placebo- and PSGAG-treated horses. Concentrations of the synovial fluid epitope CS846 were significantly higher in joints with osteoarthritis treated with ESWT CONCLUSIONS AND CLINICAL RELEVANCE: Treatment of osteoarthritis with ESWT had no effect on SCB but did induce increases in serum biomarkers indicative of bone remodeling. Treatment of osteoarthritis with PSGAG had no effect on SCB or biomarkers.

Authors+Show Affiliations

Gail Holmes Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA. ckawcak@colostate.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21627523

Citation

Kawcak, Chris E., et al. "Effects of Extracorporeal Shock Wave Therapy and Polysulfated Glycosaminoglycan Treatment On Subchondral Bone, Serum Biomarkers, and Synovial Fluid Biomarkers in Horses With Induced Osteoarthritis." American Journal of Veterinary Research, vol. 72, no. 6, 2011, pp. 772-9.
Kawcak CE, Frisbie DD, McIlwraith CW. Effects of extracorporeal shock wave therapy and polysulfated glycosaminoglycan treatment on subchondral bone, serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis. Am J Vet Res. 2011;72(6):772-9.
Kawcak, C. E., Frisbie, D. D., & McIlwraith, C. W. (2011). Effects of extracorporeal shock wave therapy and polysulfated glycosaminoglycan treatment on subchondral bone, serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis. American Journal of Veterinary Research, 72(6), 772-9. https://doi.org/10.2460/ajvr.72.6.772
Kawcak CE, Frisbie DD, McIlwraith CW. Effects of Extracorporeal Shock Wave Therapy and Polysulfated Glycosaminoglycan Treatment On Subchondral Bone, Serum Biomarkers, and Synovial Fluid Biomarkers in Horses With Induced Osteoarthritis. Am J Vet Res. 2011;72(6):772-9. PubMed PMID: 21627523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of extracorporeal shock wave therapy and polysulfated glycosaminoglycan treatment on subchondral bone, serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis. AU - Kawcak,Chris E, AU - Frisbie,David D, AU - McIlwraith,C Wayne, PY - 2011/6/2/entrez PY - 2011/6/2/pubmed PY - 2011/9/29/medline SP - 772 EP - 9 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 72 IS - 6 N2 - OBJECTIVE: To evaluate effects of extracorporeal shock wave therapy (ESWT) and polysulfated glycosaminoglycan treatment (PSGAGT) on subchondral bone (SCB), serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis. ANIMALS: 24 healthy 2- to 3-year-old horses. PROCEDURES: An osteochondral fragment was created on the distal aspect of the radial carpal bone in 1 middle carpal joint of each horse. Horses were randomly allocated to receive local application of ESWT (days 14 and 28; n = 8), PSGAGT (IM, q 4 d for 28 days; 8), or a sham ESWT probe (placebo; days 14 and 28; 8). Serum biomarkers were measured every 7 days, and synovial fluid biomarkers were measured every 14 days. Bone density was measured by use of computed tomography on days 0 and 70, and microdamage and bone formation variables were compared among groups at the end of the study (day 70). RESULTS: There was no significant effect of ESWT or PSGAGT on any bone variable. Serum osteocalcin concentration was significantly greater in horses that received ESWT, compared with placebo-treated horses, and serum concentration of the C-terminal telopeptide of type I collagen was significantly higher in horses that received ESWT, compared with placebo- and PSGAG-treated horses. Concentrations of the synovial fluid epitope CS846 were significantly higher in joints with osteoarthritis treated with ESWT CONCLUSIONS AND CLINICAL RELEVANCE: Treatment of osteoarthritis with ESWT had no effect on SCB but did induce increases in serum biomarkers indicative of bone remodeling. Treatment of osteoarthritis with PSGAG had no effect on SCB or biomarkers. SN - 1943-5681 UR - https://www.unboundmedicine.com/medline/citation/21627523/Effects_of_extracorporeal_shock_wave_therapy_and_polysulfated_glycosaminoglycan_treatment_on_subchondral_bone_serum_biomarkers_and_synovial_fluid_biomarkers_in_horses_with_induced_osteoarthritis_ L2 - http://avmajournals.avma.org/doi/full/10.2460/ajvr.72.6.772?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -