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Prospective study of clinical and histological safety of pure and uncontaminated Canadian oats in the management of celiac disease.
JPEN J Parenter Enteral Nutr 2011; 35(4):459-64JJ

Abstract

BACKGROUND

Pure oats are safe for most patients with celiac disease, but concerns regarding contamination by other grains limit their consumption. The Canadian Celiac Association recently released guidelines governing the production of pure oats. The objective was to test the safety of a product manufactured under these guidelines.

METHODS

Fifteen adults with established, biopsy-confirmed celiac disease of ≥ 1 year duration were challenged with 350 g/wk of pure oats for 12 weeks. Symptom scores, weight, hemoglobin, ferritin, albumin, and tissue transglutaminase (tTG) were assessed at weeks 0, 6, and 12. Duodenal biopsies were obtained before and after oat challenge and assessed based on the modified Marsh-Oberhuber score. Compliance with a gluten-free diet was monitored with random food diaries.

RESULTS

Fifteen patients completed the study and were analyzed in intention-to-treat and per-protocol analyses. There were no significant changes in symptom scores, weight, hemoglobin, ferritin, or albumin during oat consumption. The tTG remained negative in all patients, and the histology scores did not significantly change during oat challenge. The only relapse occurred in a patient who became noncompliant with her gluten-free diet.

CONCLUSION

The findings support the safety of pure, uncontaminated oats manufactured under Canadian Celiac Association guidelines for patients with celiac disease.

Authors+Show Affiliations

Department of Medicine, Division of Gastroenterology, University of Western Ontario, London, Ontario, Canada. msey2@uwo.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21628610

Citation

Sey, Michael Sai Lai, et al. "Prospective Study of Clinical and Histological Safety of Pure and Uncontaminated Canadian Oats in the Management of Celiac Disease." JPEN. Journal of Parenteral and Enteral Nutrition, vol. 35, no. 4, 2011, pp. 459-64.
Sey MS, Parfitt J, Gregor J. Prospective study of clinical and histological safety of pure and uncontaminated Canadian oats in the management of celiac disease. JPEN J Parenter Enteral Nutr. 2011;35(4):459-64.
Sey, M. S., Parfitt, J., & Gregor, J. (2011). Prospective study of clinical and histological safety of pure and uncontaminated Canadian oats in the management of celiac disease. JPEN. Journal of Parenteral and Enteral Nutrition, 35(4), pp. 459-64. doi:10.1177/0148607110387800.
Sey MS, Parfitt J, Gregor J. Prospective Study of Clinical and Histological Safety of Pure and Uncontaminated Canadian Oats in the Management of Celiac Disease. JPEN J Parenter Enteral Nutr. 2011;35(4):459-64. PubMed PMID: 21628610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of clinical and histological safety of pure and uncontaminated Canadian oats in the management of celiac disease. AU - Sey,Michael Sai Lai, AU - Parfitt,Jeremy, AU - Gregor,Jamie, Y1 - 2011/05/31/ PY - 2011/6/2/entrez PY - 2011/6/2/pubmed PY - 2011/11/1/medline SP - 459 EP - 64 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 35 IS - 4 N2 - BACKGROUND: Pure oats are safe for most patients with celiac disease, but concerns regarding contamination by other grains limit their consumption. The Canadian Celiac Association recently released guidelines governing the production of pure oats. The objective was to test the safety of a product manufactured under these guidelines. METHODS: Fifteen adults with established, biopsy-confirmed celiac disease of ≥ 1 year duration were challenged with 350 g/wk of pure oats for 12 weeks. Symptom scores, weight, hemoglobin, ferritin, albumin, and tissue transglutaminase (tTG) were assessed at weeks 0, 6, and 12. Duodenal biopsies were obtained before and after oat challenge and assessed based on the modified Marsh-Oberhuber score. Compliance with a gluten-free diet was monitored with random food diaries. RESULTS: Fifteen patients completed the study and were analyzed in intention-to-treat and per-protocol analyses. There were no significant changes in symptom scores, weight, hemoglobin, ferritin, or albumin during oat consumption. The tTG remained negative in all patients, and the histology scores did not significantly change during oat challenge. The only relapse occurred in a patient who became noncompliant with her gluten-free diet. CONCLUSION: The findings support the safety of pure, uncontaminated oats manufactured under Canadian Celiac Association guidelines for patients with celiac disease. SN - 1941-2444 UR - https://www.unboundmedicine.com/medline/citation/21628610/Prospective_study_of_clinical_and_histological_safety_of_pure_and_uncontaminated_Canadian_oats_in_the_management_of_celiac_disease_ L2 - https://doi.org/10.1177/0148607110387800 DB - PRIME DP - Unbound Medicine ER -