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The alpha (α)-glucosidase inhibitor, acarbose, attenuates the blood pressure and splanchnic blood flow responses to intraduodenal sucrose in older adults.
J Gerontol A Biol Sci Med Sci. 2011 Aug; 66(8):917-24.JG

Abstract

BACKGROUND

Postprandial hypotension is an important problem in the elderly and may be triggered by the increase in splanchnic blood flow induced by a meal. Acarbose attenuates the fall in blood pressure (BP) induced by oral sucrose and may be useful in the management of postprandial hypotension. It is not known whether the effect of acarbose on postprandial BP reflects slowing of gastric emptying and/or carbohydrate absorption nor whether acarbose affects splanchnic blood flow. We examined the effects of intraduodenal (ID) acarbose on the BP, heart rate, superior mesenteric artery (SMA) flow, and glycemic and insulin responses to ID sucrose in older participants--this approach excluded any "gastric" effect of acarbose.

METHODS

Eight healthy participants (four male and four female, age 66-77 years) received an ID infusion of sucrose (~6 kcal/min), with or without acarbose (100 mg), over 60 minutes. BP, heart rate, SMA flow, blood glucose, and serum insulin were measured.

RESULTS

Acarbose markedly attenuated the falls in systolic (p < .01) and diastolic (p < .05) BP and rises in heart rate (p < .05), SMA flow (p < .05), blood glucose (p < .01), and serum insulin (p < .05). The maximum fall in systolic BP and peak SMA flow was inversely related on the control day (r(2) = -.53, p < .05) but not with acarbose (r(2) = .03, p = .70).

CONCLUSIONS

We conclude that in healthy older participants receiving ID sucrose, (a) acarbose markedly attenuates the hypotensive response by slowing carbohydrate absorption and attenuating the rise in splanchnic blood flow and (b) the fall in BP is related to the concomitant increase in SMA flow.

Authors+Show Affiliations

Discipline of Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21628676

Citation

Gentilcore, Diana, et al. "The Alpha (α)-glucosidase Inhibitor, Acarbose, Attenuates the Blood Pressure and Splanchnic Blood Flow Responses to Intraduodenal Sucrose in Older Adults." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 66, no. 8, 2011, pp. 917-24.
Gentilcore D, Vanis L, Wishart JM, et al. The alpha (α)-glucosidase inhibitor, acarbose, attenuates the blood pressure and splanchnic blood flow responses to intraduodenal sucrose in older adults. J Gerontol A Biol Sci Med Sci. 2011;66(8):917-24.
Gentilcore, D., Vanis, L., Wishart, J. M., Rayner, C. K., Horowitz, M., & Jones, K. L. (2011). The alpha (α)-glucosidase inhibitor, acarbose, attenuates the blood pressure and splanchnic blood flow responses to intraduodenal sucrose in older adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 66(8), 917-24. https://doi.org/10.1093/gerona/glr086
Gentilcore D, et al. The Alpha (α)-glucosidase Inhibitor, Acarbose, Attenuates the Blood Pressure and Splanchnic Blood Flow Responses to Intraduodenal Sucrose in Older Adults. J Gerontol A Biol Sci Med Sci. 2011;66(8):917-24. PubMed PMID: 21628676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The alpha (α)-glucosidase inhibitor, acarbose, attenuates the blood pressure and splanchnic blood flow responses to intraduodenal sucrose in older adults. AU - Gentilcore,Diana, AU - Vanis,Lora, AU - Wishart,Judith M, AU - Rayner,Christopher K, AU - Horowitz,Michael, AU - Jones,Karen L, Y1 - 2011/05/31/ PY - 2011/6/2/entrez PY - 2011/6/2/pubmed PY - 2011/9/29/medline SP - 917 EP - 24 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J Gerontol A Biol Sci Med Sci VL - 66 IS - 8 N2 - BACKGROUND: Postprandial hypotension is an important problem in the elderly and may be triggered by the increase in splanchnic blood flow induced by a meal. Acarbose attenuates the fall in blood pressure (BP) induced by oral sucrose and may be useful in the management of postprandial hypotension. It is not known whether the effect of acarbose on postprandial BP reflects slowing of gastric emptying and/or carbohydrate absorption nor whether acarbose affects splanchnic blood flow. We examined the effects of intraduodenal (ID) acarbose on the BP, heart rate, superior mesenteric artery (SMA) flow, and glycemic and insulin responses to ID sucrose in older participants--this approach excluded any "gastric" effect of acarbose. METHODS: Eight healthy participants (four male and four female, age 66-77 years) received an ID infusion of sucrose (~6 kcal/min), with or without acarbose (100 mg), over 60 minutes. BP, heart rate, SMA flow, blood glucose, and serum insulin were measured. RESULTS: Acarbose markedly attenuated the falls in systolic (p < .01) and diastolic (p < .05) BP and rises in heart rate (p < .05), SMA flow (p < .05), blood glucose (p < .01), and serum insulin (p < .05). The maximum fall in systolic BP and peak SMA flow was inversely related on the control day (r(2) = -.53, p < .05) but not with acarbose (r(2) = .03, p = .70). CONCLUSIONS: We conclude that in healthy older participants receiving ID sucrose, (a) acarbose markedly attenuates the hypotensive response by slowing carbohydrate absorption and attenuating the rise in splanchnic blood flow and (b) the fall in BP is related to the concomitant increase in SMA flow. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/21628676/The_alpha__α__glucosidase_inhibitor_acarbose_attenuates_the_blood_pressure_and_splanchnic_blood_flow_responses_to_intraduodenal_sucrose_in_older_adults_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glr086 DB - PRIME DP - Unbound Medicine ER -