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Hypothalamic-pituitary-adrenal axis reactivity to social stress and adolescent cannabis use: the TRAILS study.
Addiction. 2011 Aug; 106(8):1484-92.A

Abstract

AIMS

To investigate the relationship of life-time and repeated cannabis use with hypothalamic-pituitary-adrenal (HPA) axis reactivity to social stress in a general population sample of adolescents.

DESIGN

Adolescents who reported life-time or repeated cannabis use, life-time or repeated tobacco use and never use of either cannabis or tobacco were compared with respect to their HPA axis reactivity during the Groningen Social Stress Task (GSST), which was based on the Trier Social Stress Task.

SETTING

A large prospective population study of Dutch adolescents [the TRacking Adolescents' Individual Lives Survey (TRAILS) study].

PARTICIPANTS

A total of 591 adolescents (51% male) who participated in the GSST, which was an additional measurement during the third assessment wave.

MEASUREMENTS

HPA axis stress-reactivity was indexed by four cortisol samples collected before, during and after the GSST. Furthermore, all adolescents in our study completed self-reported questionnaires on life-time and repeated cannabis and tobacco use. Models were adjusted for sex, recent alcohol use, experimental session risk status, socio-economic status, mood and time of the experimental session.

FINDINGS

Life-time cannabis users had significantly lower stress-reactivity levels when compared to abstainers [odds ratio (OR) = 0.68, confidence interval (CI) = 0.55-0.85, P < 0.01] and life-time tobacco users (OR = 0.79, CI = 0.64-0.98, P < 0.05). In addition, repeated cannabis users also exhibited lower stress-reactivity levels when compared to life-time ever users of either tobacco or cannabis (OR = 0.74, CI = 0.53-0.98, P < 0.05).

CONCLUSIONS

Lower hypothalamic-pituitary-adrenal-axis stress-reactivity in adolescents is related specifically to life-time and repeated cannabis use.

Authors+Show Affiliations

Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21631618

Citation

van Leeuwen, Andrea Prince, et al. "Hypothalamic-pituitary-adrenal Axis Reactivity to Social Stress and Adolescent Cannabis Use: the TRAILS Study." Addiction (Abingdon, England), vol. 106, no. 8, 2011, pp. 1484-92.
van Leeuwen AP, Creemers HE, Greaves-Lord K, et al. Hypothalamic-pituitary-adrenal axis reactivity to social stress and adolescent cannabis use: the TRAILS study. Addiction. 2011;106(8):1484-92.
van Leeuwen, A. P., Creemers, H. E., Greaves-Lord, K., Verhulst, F. C., Ormel, J., & Huizink, A. C. (2011). Hypothalamic-pituitary-adrenal axis reactivity to social stress and adolescent cannabis use: the TRAILS study. Addiction (Abingdon, England), 106(8), 1484-92. https://doi.org/10.1111/j.1360-0443.2011.03448.x
van Leeuwen AP, et al. Hypothalamic-pituitary-adrenal Axis Reactivity to Social Stress and Adolescent Cannabis Use: the TRAILS Study. Addiction. 2011;106(8):1484-92. PubMed PMID: 21631618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypothalamic-pituitary-adrenal axis reactivity to social stress and adolescent cannabis use: the TRAILS study. AU - van Leeuwen,Andrea Prince, AU - Creemers,Hanneke E, AU - Greaves-Lord,Kirstin, AU - Verhulst,Frank C, AU - Ormel,Johan, AU - Huizink,Anja C, Y1 - 2011/06/01/ PY - 2011/6/3/entrez PY - 2011/6/3/pubmed PY - 2011/12/13/medline SP - 1484 EP - 92 JF - Addiction (Abingdon, England) JO - Addiction VL - 106 IS - 8 N2 - AIMS: To investigate the relationship of life-time and repeated cannabis use with hypothalamic-pituitary-adrenal (HPA) axis reactivity to social stress in a general population sample of adolescents. DESIGN: Adolescents who reported life-time or repeated cannabis use, life-time or repeated tobacco use and never use of either cannabis or tobacco were compared with respect to their HPA axis reactivity during the Groningen Social Stress Task (GSST), which was based on the Trier Social Stress Task. SETTING: A large prospective population study of Dutch adolescents [the TRacking Adolescents' Individual Lives Survey (TRAILS) study]. PARTICIPANTS: A total of 591 adolescents (51% male) who participated in the GSST, which was an additional measurement during the third assessment wave. MEASUREMENTS: HPA axis stress-reactivity was indexed by four cortisol samples collected before, during and after the GSST. Furthermore, all adolescents in our study completed self-reported questionnaires on life-time and repeated cannabis and tobacco use. Models were adjusted for sex, recent alcohol use, experimental session risk status, socio-economic status, mood and time of the experimental session. FINDINGS: Life-time cannabis users had significantly lower stress-reactivity levels when compared to abstainers [odds ratio (OR) = 0.68, confidence interval (CI) = 0.55-0.85, P < 0.01] and life-time tobacco users (OR = 0.79, CI = 0.64-0.98, P < 0.05). In addition, repeated cannabis users also exhibited lower stress-reactivity levels when compared to life-time ever users of either tobacco or cannabis (OR = 0.74, CI = 0.53-0.98, P < 0.05). CONCLUSIONS: Lower hypothalamic-pituitary-adrenal-axis stress-reactivity in adolescents is related specifically to life-time and repeated cannabis use. SN - 1360-0443 UR - https://www.unboundmedicine.com/medline/citation/21631618/Hypothalamic_pituitary_adrenal_axis_reactivity_to_social_stress_and_adolescent_cannabis_use:_the_TRAILS_study_ L2 - https://doi.org/10.1111/j.1360-0443.2011.03448.x DB - PRIME DP - Unbound Medicine ER -