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Third trimester plasma adiponectin and leptin in gestational diabetes and normal pregnancies.
Diabetes Res Clin Pract 2011; 93(3):350-6DR

Abstract

The aim of this study was to compare pregnant women with and without gestational diabetes (GDM) with regard to third trimester adiponectin, leptin and insulin resistance, as well as to investigate their relation to fetal growth and macrosomia. 134 pregnant women were enrolled in the study: 86 with GDM and 48 controls. Maternal plasma adiponectin, leptin, fasting insulin, glucose and fetal biometry were measured between 27 and 32 weeks of gestation. Birthweight and delivery data were also assessed. Adiponectin in GDM patients was lower when compared to non-diabetic women while mean leptin concentration was not different. In GDM group only mothers' weight gain until third trimester was significantly different between the groups of patients with normal and accelerated fetal growth. No correlation of adiponectin and leptin with fetal growth was shown. Mothers' weight gain until third trimester and mean fasting glucose between 33 and 34 weeks of gestation were associated with neonatal macrosomia. There were no differences in adiponectin and leptin between mothers of macrosomic and non-macrosomic neonates. Fetal growth seems not to be related to third trimester adiponectin and leptin concentrations, while increased third trimester fasting glucose may be an independent risk factor of macrosomia.

Authors+Show Affiliations

1st Department of Obstetrics and Gynaecology, Medical University of Warsaw, Poland. edytahorosz@tlen.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21632143

Citation

Horosz, Edyta, et al. "Third Trimester Plasma Adiponectin and Leptin in Gestational Diabetes and Normal Pregnancies." Diabetes Research and Clinical Practice, vol. 93, no. 3, 2011, pp. 350-6.
Horosz E, Bomba-Opon DA, Szymanska M, et al. Third trimester plasma adiponectin and leptin in gestational diabetes and normal pregnancies. Diabetes Res Clin Pract. 2011;93(3):350-6.
Horosz, E., Bomba-Opon, D. A., Szymanska, M., & Wielgos, M. (2011). Third trimester plasma adiponectin and leptin in gestational diabetes and normal pregnancies. Diabetes Research and Clinical Practice, 93(3), pp. 350-6. doi:10.1016/j.diabres.2011.05.005.
Horosz E, et al. Third Trimester Plasma Adiponectin and Leptin in Gestational Diabetes and Normal Pregnancies. Diabetes Res Clin Pract. 2011;93(3):350-6. PubMed PMID: 21632143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Third trimester plasma adiponectin and leptin in gestational diabetes and normal pregnancies. AU - Horosz,Edyta, AU - Bomba-Opon,Dorota A, AU - Szymanska,Monika, AU - Wielgos,Miroslaw, Y1 - 2011/05/31/ PY - 2011/02/14/received PY - 2011/04/26/revised PY - 2011/05/05/accepted PY - 2011/6/3/entrez PY - 2011/6/3/pubmed PY - 2012/4/25/medline SP - 350 EP - 6 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 93 IS - 3 N2 - The aim of this study was to compare pregnant women with and without gestational diabetes (GDM) with regard to third trimester adiponectin, leptin and insulin resistance, as well as to investigate their relation to fetal growth and macrosomia. 134 pregnant women were enrolled in the study: 86 with GDM and 48 controls. Maternal plasma adiponectin, leptin, fasting insulin, glucose and fetal biometry were measured between 27 and 32 weeks of gestation. Birthweight and delivery data were also assessed. Adiponectin in GDM patients was lower when compared to non-diabetic women while mean leptin concentration was not different. In GDM group only mothers' weight gain until third trimester was significantly different between the groups of patients with normal and accelerated fetal growth. No correlation of adiponectin and leptin with fetal growth was shown. Mothers' weight gain until third trimester and mean fasting glucose between 33 and 34 weeks of gestation were associated with neonatal macrosomia. There were no differences in adiponectin and leptin between mothers of macrosomic and non-macrosomic neonates. Fetal growth seems not to be related to third trimester adiponectin and leptin concentrations, while increased third trimester fasting glucose may be an independent risk factor of macrosomia. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/21632143/Third_trimester_plasma_adiponectin_and_leptin_in_gestational_diabetes_and_normal_pregnancies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(11)00232-4 DB - PRIME DP - Unbound Medicine ER -