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Decreased resting energy expenditure in patients with Duchenne muscular dystrophy.
Brain Dev. 2012 Mar; 34(3):206-12.BD

Abstract

BACKGROUND

Skeletal muscle metabolism is a major determinant of resting energy expenditure (REE). Although the severe muscle loss that characterizes Duchenne muscular dystrophy (DMD) may alter REE, this has not been extensively investigated.

METHODS

We studied REE in 77 patients with DMD ranging in age from 10 to 37 years using a portable indirect calorimeter, together with several clinical parameters (age, height, body weight (BW), body mass index (BMI), vital capacity (VC), creatine kinase, creatinine, albumin, cholinesterase, prealbumin), and assessed their influence on REE. In addition, in 12 patients maintaining a stable body weight, the ratio of energy intake to REE was calculated and defined as an alternative index for the physical activity level (aPAL).

RESULTS

REE (kcal/day, mean±SD) in DMD patients was 1123 (10-11 years), 1186±188 (12-14 years), 1146±214 (15-17 years), 1006±136 (18-29 years) and 1023±97 (≥30 years), each of these values being significantly lower than the corresponding control (p<0.0001). VC (p<0.001) was the parameter most strongly associated with REE, followed by BMI (p<0.01) and BW (p<0.05). The calculated aPAL values were 1.61 (10-11 years), 1.19 (12-14 years), 1.16 (15-17 years), and 1.57 (18-29 years).

CONCLUSION

The REE in DMD patients was significantly lower than the normal value in every age group, and strongly associated with VC. Both the low REE and PAL values during the early teens, resulting in a low energy requirement, might be related to the obesity that frequently occurs in this age group. In contrast, the high PAL value in the late stage of the disease, possibly due to the presence of respiratory failure, may lead to a high energy requirement, and thus become one of the risk factors for development of malnutrition.

Authors+Show Affiliations

Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21632191

Citation

Shimizu-Fujiwara, Mami, et al. "Decreased Resting Energy Expenditure in Patients With Duchenne Muscular Dystrophy." Brain & Development, vol. 34, no. 3, 2012, pp. 206-12.
Shimizu-Fujiwara M, Komaki H, Nakagawa E, et al. Decreased resting energy expenditure in patients with Duchenne muscular dystrophy. Brain Dev. 2012;34(3):206-12.
Shimizu-Fujiwara, M., Komaki, H., Nakagawa, E., Mori-Yoshimura, M., Oya, Y., Fujisaki, T., Tokita, Y., Kubota, N., Shimazaki, R., Sato, K., Ishikawa, T., Goto, K., Mochizuki, H., Takanoha, S., Ogata, K., Kawai, M., Konagaya, M., Miyazaki, T., Tatara, K., ... Sasaki, M. (2012). Decreased resting energy expenditure in patients with Duchenne muscular dystrophy. Brain & Development, 34(3), 206-12. https://doi.org/10.1016/j.braindev.2011.05.005
Shimizu-Fujiwara M, et al. Decreased Resting Energy Expenditure in Patients With Duchenne Muscular Dystrophy. Brain Dev. 2012;34(3):206-12. PubMed PMID: 21632191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased resting energy expenditure in patients with Duchenne muscular dystrophy. AU - Shimizu-Fujiwara,Mami, AU - Komaki,Hirofumi, AU - Nakagawa,Eiji, AU - Mori-Yoshimura,Madoka, AU - Oya,Yasushi, AU - Fujisaki,Toshiyuki, AU - Tokita,Yasuko, AU - Kubota,Norika, AU - Shimazaki,Rie, AU - Sato,Kimiko, AU - Ishikawa,Tomoko, AU - Goto,Katsumasa, AU - Mochizuki,Hitoshi, AU - Takanoha,Satoko, AU - Ogata,Katsuhisa, AU - Kawai,Mitsuru, AU - Konagaya,Masaaki, AU - Miyazaki,Tatsushi, AU - Tatara,Katsunori, AU - Sugai,Kenji, AU - Sasaki,Masayuki, Y1 - 2011/05/31/ PY - 2009/11/25/received PY - 2011/05/05/revised PY - 2011/05/06/accepted PY - 2011/6/3/entrez PY - 2011/6/3/pubmed PY - 2012/6/5/medline SP - 206 EP - 12 JF - Brain & development JO - Brain Dev. VL - 34 IS - 3 N2 - BACKGROUND: Skeletal muscle metabolism is a major determinant of resting energy expenditure (REE). Although the severe muscle loss that characterizes Duchenne muscular dystrophy (DMD) may alter REE, this has not been extensively investigated. METHODS: We studied REE in 77 patients with DMD ranging in age from 10 to 37 years using a portable indirect calorimeter, together with several clinical parameters (age, height, body weight (BW), body mass index (BMI), vital capacity (VC), creatine kinase, creatinine, albumin, cholinesterase, prealbumin), and assessed their influence on REE. In addition, in 12 patients maintaining a stable body weight, the ratio of energy intake to REE was calculated and defined as an alternative index for the physical activity level (aPAL). RESULTS: REE (kcal/day, mean±SD) in DMD patients was 1123 (10-11 years), 1186±188 (12-14 years), 1146±214 (15-17 years), 1006±136 (18-29 years) and 1023±97 (≥30 years), each of these values being significantly lower than the corresponding control (p<0.0001). VC (p<0.001) was the parameter most strongly associated with REE, followed by BMI (p<0.01) and BW (p<0.05). The calculated aPAL values were 1.61 (10-11 years), 1.19 (12-14 years), 1.16 (15-17 years), and 1.57 (18-29 years). CONCLUSION: The REE in DMD patients was significantly lower than the normal value in every age group, and strongly associated with VC. Both the low REE and PAL values during the early teens, resulting in a low energy requirement, might be related to the obesity that frequently occurs in this age group. In contrast, the high PAL value in the late stage of the disease, possibly due to the presence of respiratory failure, may lead to a high energy requirement, and thus become one of the risk factors for development of malnutrition. SN - 1872-7131 UR - https://www.unboundmedicine.com/medline/citation/21632191/Decreased_resting_energy_expenditure_in_patients_with_Duchenne_muscular_dystrophy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0387-7604(11)00139-2 DB - PRIME DP - Unbound Medicine ER -