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Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes.
JAMA 2011; 305(21):2184-92JAMA

Abstract

CONTEXT

Type 2 diabetes mellitus (DM) is associated with higher bone mineral density (BMD) and paradoxically with increased fracture risk. It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM.

OBJECTIVE

To determine if femoral neck BMD T score and the World Health Organization Fracture Risk Algorithm (FRAX) score are associated with hip and nonspine fracture risk in older adults with type 2 DM.

DESIGN, SETTING, AND PARTICIPANTS

Data from 3 prospective observational studies with adjudicated fracture outcomes (Study of Osteoporotic Fractures [December 1998-July 2008]; Osteoporotic Fractures in Men Study [March 2000-March 2009]; and Health, Aging, and Body Composition study [April 1997-June 2007]) were analyzed in older community-dwelling adults (9449 women and 7436 men) in the United States.

MAIN OUTCOME MEASURE

Self-reported incident fractures, which were verified by radiology reports.

RESULTS

Of 770 women with DM, 84 experienced a hip fracture and 262 a nonspine fracture during a mean (SD) follow-up of 12.6 (5.3) years. Of 1199 men with DM, 32 experienced a hip fracture and 133 a nonspine fracture during a mean (SD) follow-up of 7.5 (2.0) years. Age-adjusted hazard ratios (HRs) for 1-unit decrease in femoral neck BMD T score in women with DM were 1.88 (95% confidence interval [CI], 1.43-2.48) for hip fracture and 1.52 (95% CI, 1.31-1.75) for nonspine fracture, and in men with DM were 5.71 (95% CI, 3.42-9.53) for hip fracture and 2.17 (95% CI, 1.75-2.69) for nonspine fracture. The FRAX score was also associated with fracture risk in participants with DM (HRs for 1-unit increase in FRAX hip fracture score, 1.05; 95% CI, 1.03-1.07, for women with DM and 1.16; 95% CI, 1.07-1.27, for men with DM; HRs for 1-unit increase in FRAX osteoporotic fracture score, 1.04; 95% CI, 1.02-1.05, for women with DM and 1.09; 95% CI, 1.04-1.14, for men with DM). However, for a given T score and age or for a given FRAX score, participants with DM had a higher fracture risk than those without DM. For a similar fracture risk, participants with DM had a higher T score than participants without DM. For hip fracture, the estimated mean difference in T score for women was 0.59 (95% CI, 0.31-0.87) and for men was 0.38 (95% CI, 0.09-0.66).

CONCLUSIONS

Among older adults with type 2 DM, femoral neck BMD T score and FRAX score were associated with hip and nonspine fracture risk; however, in these patients compared with participants without DM, the fracture risk was higher for a given T score and age or for a given FRAX score.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107-1762, USA. aschwartz@psg.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21632482

Citation

Schwartz, Ann V., et al. "Association of BMD and FRAX Score With Risk of Fracture in Older Adults With Type 2 Diabetes." JAMA, vol. 305, no. 21, 2011, pp. 2184-92.
Schwartz AV, Vittinghoff E, Bauer DC, et al. Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes. JAMA. 2011;305(21):2184-92.
Schwartz, A. V., Vittinghoff, E., Bauer, D. C., Hillier, T. A., Strotmeyer, E. S., Ensrud, K. E., ... Black, D. M. (2011). Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes. JAMA, 305(21), pp. 2184-92. doi:10.1001/jama.2011.715.
Schwartz AV, et al. Association of BMD and FRAX Score With Risk of Fracture in Older Adults With Type 2 Diabetes. JAMA. 2011 Jun 1;305(21):2184-92. PubMed PMID: 21632482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes. AU - Schwartz,Ann V, AU - Vittinghoff,Eric, AU - Bauer,Douglas C, AU - Hillier,Teresa A, AU - Strotmeyer,Elsa S, AU - Ensrud,Kristine E, AU - Donaldson,Meghan G, AU - Cauley,Jane A, AU - Harris,Tamara B, AU - Koster,Annemarie, AU - Womack,Catherine R, AU - Palermo,Lisa, AU - Black,Dennis M, AU - ,, AU - ,, AU - ,, PY - 2011/6/3/entrez PY - 2011/6/3/pubmed PY - 2011/6/4/medline SP - 2184 EP - 92 JF - JAMA JO - JAMA VL - 305 IS - 21 N2 - CONTEXT: Type 2 diabetes mellitus (DM) is associated with higher bone mineral density (BMD) and paradoxically with increased fracture risk. It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM. OBJECTIVE: To determine if femoral neck BMD T score and the World Health Organization Fracture Risk Algorithm (FRAX) score are associated with hip and nonspine fracture risk in older adults with type 2 DM. DESIGN, SETTING, AND PARTICIPANTS: Data from 3 prospective observational studies with adjudicated fracture outcomes (Study of Osteoporotic Fractures [December 1998-July 2008]; Osteoporotic Fractures in Men Study [March 2000-March 2009]; and Health, Aging, and Body Composition study [April 1997-June 2007]) were analyzed in older community-dwelling adults (9449 women and 7436 men) in the United States. MAIN OUTCOME MEASURE: Self-reported incident fractures, which were verified by radiology reports. RESULTS: Of 770 women with DM, 84 experienced a hip fracture and 262 a nonspine fracture during a mean (SD) follow-up of 12.6 (5.3) years. Of 1199 men with DM, 32 experienced a hip fracture and 133 a nonspine fracture during a mean (SD) follow-up of 7.5 (2.0) years. Age-adjusted hazard ratios (HRs) for 1-unit decrease in femoral neck BMD T score in women with DM were 1.88 (95% confidence interval [CI], 1.43-2.48) for hip fracture and 1.52 (95% CI, 1.31-1.75) for nonspine fracture, and in men with DM were 5.71 (95% CI, 3.42-9.53) for hip fracture and 2.17 (95% CI, 1.75-2.69) for nonspine fracture. The FRAX score was also associated with fracture risk in participants with DM (HRs for 1-unit increase in FRAX hip fracture score, 1.05; 95% CI, 1.03-1.07, for women with DM and 1.16; 95% CI, 1.07-1.27, for men with DM; HRs for 1-unit increase in FRAX osteoporotic fracture score, 1.04; 95% CI, 1.02-1.05, for women with DM and 1.09; 95% CI, 1.04-1.14, for men with DM). However, for a given T score and age or for a given FRAX score, participants with DM had a higher fracture risk than those without DM. For a similar fracture risk, participants with DM had a higher T score than participants without DM. For hip fracture, the estimated mean difference in T score for women was 0.59 (95% CI, 0.31-0.87) and for men was 0.38 (95% CI, 0.09-0.66). CONCLUSIONS: Among older adults with type 2 DM, femoral neck BMD T score and FRAX score were associated with hip and nonspine fracture risk; however, in these patients compared with participants without DM, the fracture risk was higher for a given T score and age or for a given FRAX score. SN - 1538-3598 UR - https://www.unboundmedicine.com/medline/citation/21632482/Association_of_BMD_and_FRAX_score_with_risk_of_fracture_in_older_adults_with_type_2_diabetes_ L2 - https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2011.715 DB - PRIME DP - Unbound Medicine ER -