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Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis.
Am J Trop Med Hyg. 2011 Jun; 84(6):858-61.AJ

Abstract

Melioidosis, a bacterial infection caused by Burkholderia pseudomallei, is notoriously difficult to cure despite appropriate antimicrobial therapy and has a mortality rate of up to 40%. We demonstrate that a blood culture positive for B. pseudomallei taken at the end of the first and/or second week after hospitalization for melioidosis is a strong prognostic factor for death (adjusted odds ratio = 4.2, 95% confidence interval = 2.1-8.7, P < 0.001 and adjusted odds ratio = 2.6, 95% confidence interval = 1.1-6.0, P = 0.03, respectively). However, repeat cultures of respiratory secretions, urine, throat swabs, or pus/surface swabs provide no prognostic information. This finding highlights the need for follow-up blood cultures in patients with melioidosis.

Authors+Show Affiliations

Department of Tropical Hygiene, Department of Microbiology and Immunology and Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithee Road, Bangkok, Thailand. direk@tropmedres.acNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21633019

Citation

Limmathurotsakul, Direk, et al. "Repeat Blood Culture Positive for B. Pseudomallei Indicates an Increased Risk of Death From Melioidosis." The American Journal of Tropical Medicine and Hygiene, vol. 84, no. 6, 2011, pp. 858-61.
Limmathurotsakul D, Wuthiekanun V, Wongsuvan G, et al. Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis. Am J Trop Med Hyg. 2011;84(6):858-61.
Limmathurotsakul, D., Wuthiekanun, V., Wongsuvan, G., Pangmee, S., Amornchai, P., Teparrakkul, P., Teerawattanasook, N., Day, N. P., & Peacock, S. J. (2011). Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis. The American Journal of Tropical Medicine and Hygiene, 84(6), 858-61. https://doi.org/10.4269/ajtmh.2011.10-0618
Limmathurotsakul D, et al. Repeat Blood Culture Positive for B. Pseudomallei Indicates an Increased Risk of Death From Melioidosis. Am J Trop Med Hyg. 2011;84(6):858-61. PubMed PMID: 21633019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis. AU - Limmathurotsakul,Direk, AU - Wuthiekanun,Vanaporn, AU - Wongsuvan,Gumphol, AU - Pangmee,Sukanya, AU - Amornchai,Premjit, AU - Teparrakkul,Prapit, AU - Teerawattanasook,Nittaya, AU - Day,Nicholas P J, AU - Peacock,Sharon J, PY - 2011/6/3/entrez PY - 2011/6/3/pubmed PY - 2011/8/5/medline SP - 858 EP - 61 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 84 IS - 6 N2 - Melioidosis, a bacterial infection caused by Burkholderia pseudomallei, is notoriously difficult to cure despite appropriate antimicrobial therapy and has a mortality rate of up to 40%. We demonstrate that a blood culture positive for B. pseudomallei taken at the end of the first and/or second week after hospitalization for melioidosis is a strong prognostic factor for death (adjusted odds ratio = 4.2, 95% confidence interval = 2.1-8.7, P < 0.001 and adjusted odds ratio = 2.6, 95% confidence interval = 1.1-6.0, P = 0.03, respectively). However, repeat cultures of respiratory secretions, urine, throat swabs, or pus/surface swabs provide no prognostic information. This finding highlights the need for follow-up blood cultures in patients with melioidosis. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/21633019/Repeat_blood_culture_positive_for_B__pseudomallei_indicates_an_increased_risk_of_death_from_melioidosis_ L2 - https://ajtmh.org/doi/10.4269/ajtmh.2011.10-0618 DB - PRIME DP - Unbound Medicine ER -