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Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases.
Nephrol Dial Transplant. 2011 Aug; 26(8):2712-4.ND

Abstract

Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a recently described entity that is only rarely associated with a hematological or lymphoproliferative malignancy. We describe the cases of two men with preexisting chronic lymphocytic leukemia (CLL) who developed endocapillary proliferative glomerulonephritis with nonorganized monoclonal IgG(1) deposits. One biopsy also showed CLL infiltration of the cortex. Both patients were treated with rituximab in addition to cyclophosphamide in one case and fludarabine in the other with significant improvement of their renal disease and CLL. This report provides additional evidence to support the use of rituximab in the therapy of CLL-associated PGNMID.

Authors+Show Affiliations

Department of Nephrology, University of British Columbia, Vancouver, Canada. seanbarbour@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21633102

Citation

Barbour, Sean J., et al. "Proliferative Glomerulonephritis With Monoclonal IgG Deposits Secondary to Chronic Lymphocytic Leukemia. Report of Two Cases." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 26, no. 8, 2011, pp. 2712-4.
Barbour SJ, Beaulieu MC, Zalunardo NY, et al. Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases. Nephrol Dial Transplant. 2011;26(8):2712-4.
Barbour, S. J., Beaulieu, M. C., Zalunardo, N. Y., & Magil, A. B. (2011). Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 26(8), 2712-4. https://doi.org/10.1093/ndt/gfr251
Barbour SJ, et al. Proliferative Glomerulonephritis With Monoclonal IgG Deposits Secondary to Chronic Lymphocytic Leukemia. Report of Two Cases. Nephrol Dial Transplant. 2011;26(8):2712-4. PubMed PMID: 21633102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases. AU - Barbour,Sean J, AU - Beaulieu,Monica C, AU - Zalunardo,Nadia Y, AU - Magil,Alex B, Y1 - 2011/06/01/ PY - 2011/6/3/entrez PY - 2011/6/3/pubmed PY - 2011/12/21/medline SP - 2712 EP - 4 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol. Dial. Transplant. VL - 26 IS - 8 N2 - Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a recently described entity that is only rarely associated with a hematological or lymphoproliferative malignancy. We describe the cases of two men with preexisting chronic lymphocytic leukemia (CLL) who developed endocapillary proliferative glomerulonephritis with nonorganized monoclonal IgG(1) deposits. One biopsy also showed CLL infiltration of the cortex. Both patients were treated with rituximab in addition to cyclophosphamide in one case and fludarabine in the other with significant improvement of their renal disease and CLL. This report provides additional evidence to support the use of rituximab in the therapy of CLL-associated PGNMID. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/21633102/Proliferative_glomerulonephritis_with_monoclonal_IgG_deposits_secondary_to_chronic_lymphocytic_leukemia__Report_of_two_cases_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfr251 DB - PRIME DP - Unbound Medicine ER -