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[Aripiprazole use in children and adolescent psychiatric patients].
Therapie. 2011 Mar-Apr; 66(2):123-30.T

Abstract

Aripiprazole inaugurates a new generation of antipsychotics called dopamine-serotonin system stabilizers. Its mechanism of action is different as aripiprazole is a partial dopamine D(2) and serotonin 5-HT(1A) receptor agonist and 5-HT(2A) receptor antagonist. Therefore, aripiprazole is thought to have an antagonistic action in the mesolimbic pathway but an agonistic action in the mesocortical pathway, tending to normalize the dopaminergic transmission regardless of the type of imbalance. Clinical trials involving children and adolescents have demonstrated the efficacy of aripiprazole in bipolar disorders, schizophrenia, mood disorders associated with pervasive developmental disorders, in tics and Tourette's. The most frequent side effects are extrapyramidal symptoms and sleepiness and are dose-dependent. Nevertheless, contrary to other second-generation antipsychotics available in France, it induces little weight gain, does not modify lipid and glucidic profiles, does not increase prolactin levels, or induce QTc lengthening. The main advantage of aripiprazole is its good safety profile, with different toxicity targets to other second-generation antipsychotics available in France. Aripiprazole appears to be an alternative for children and adolescents who are vulnerable to these side effects and are having trouble coping with them.

Authors+Show Affiliations

Service de Psychiatrie Infanto-Juvénile, CH Guillaume Régnier, Rennes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

21635859

Citation

Chevreuil, Claire, et al. "[Aripiprazole Use in Children and Adolescent Psychiatric Patients]." Therapie, vol. 66, no. 2, 2011, pp. 123-30.
Chevreuil C, Polard E, Lemonnier E, et al. [Aripiprazole use in children and adolescent psychiatric patients]. Therapie. 2011;66(2):123-30.
Chevreuil, C., Polard, E., Lemonnier, E., Guillemot, P., & Bentué-Ferrer, D. (2011). [Aripiprazole use in children and adolescent psychiatric patients]. Therapie, 66(2), 123-30.
Chevreuil C, et al. [Aripiprazole Use in Children and Adolescent Psychiatric Patients]. Therapie. 2011 Mar-Apr;66(2):123-30. PubMed PMID: 21635859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Aripiprazole use in children and adolescent psychiatric patients]. AU - Chevreuil,Claire, AU - Polard,Elisabeth, AU - Lemonnier,Eric, AU - Guillemot,Paul, AU - Bentué-Ferrer,Danièle, AU - ,, Y1 - 2011/06/06/ PY - 2010/06/29/received PY - 2010/10/12/accepted PY - 2011/6/4/entrez PY - 2011/6/4/pubmed PY - 2013/1/5/medline SP - 123 EP - 30 JF - Therapie JO - Therapie VL - 66 IS - 2 N2 - Aripiprazole inaugurates a new generation of antipsychotics called dopamine-serotonin system stabilizers. Its mechanism of action is different as aripiprazole is a partial dopamine D(2) and serotonin 5-HT(1A) receptor agonist and 5-HT(2A) receptor antagonist. Therefore, aripiprazole is thought to have an antagonistic action in the mesolimbic pathway but an agonistic action in the mesocortical pathway, tending to normalize the dopaminergic transmission regardless of the type of imbalance. Clinical trials involving children and adolescents have demonstrated the efficacy of aripiprazole in bipolar disorders, schizophrenia, mood disorders associated with pervasive developmental disorders, in tics and Tourette's. The most frequent side effects are extrapyramidal symptoms and sleepiness and are dose-dependent. Nevertheless, contrary to other second-generation antipsychotics available in France, it induces little weight gain, does not modify lipid and glucidic profiles, does not increase prolactin levels, or induce QTc lengthening. The main advantage of aripiprazole is its good safety profile, with different toxicity targets to other second-generation antipsychotics available in France. Aripiprazole appears to be an alternative for children and adolescents who are vulnerable to these side effects and are having trouble coping with them. SN - 0040-5957 UR - https://www.unboundmedicine.com/medline/citation/21635859/[Aripiprazole_use_in_children_and_adolescent_psychiatric_patients]_ L2 - http://publications.edpsciences.org/10.2515/therapie/2011012 DB - PRIME DP - Unbound Medicine ER -