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Consumption of legumes improves certain bone markers in ovariectomized rats.
Nutr Res. 2011 May; 31(5):397-403.NR

Abstract

Soybeans are known to protect against osteoporosis, but other legumes frequently consumed in Asia have not been studied to learn if they have a similar protective effect. This study investigated the hypothesis that consumption of soybean, mung bean, cowpea, and adzuki bean has beneficial effects on bone biomarkers in ovariectomized rats. Female Sprague-Dawley rats were either sham operated (sham; n = 7) or surgically ovariectomized and then fed a regular AIN-93M diet (OVX; n = 7) or AIN-93M containing soybean (n = 7), mung bean (n = 7), cowpea (n = 7), or adzuki beans (n = 7) for 10 weeks. No bean consumption significantly altered the body, subcutaneous fat, or uterus weight; however, consumption significantly increased the serum calcium/phosphorous ratio and decreased urinary calcium excretion compared with those of the OVX group. Serum concentration of 17β-estradiol was significantly lower in the OVX group compared with that of the sham group and was lowest in the group fed OVX diet containing soybean. Serum osteocalcin concentration was significantly higher in all OVX rats given a diet with beans compared with the same diet without, but urinary deoxypyridinoline excretion was lowest in the group fed OVX diet containing cowpea. There were no significant differences in bone mineral density or bone mineral content of the right femur, tibia, or lumbar spine or in the trabecular bone volume of the tibia among the diet groups. In conclusion, the consumption of soybean, mung bean, cowpea, and adzuki bean in OVX rats improved osteocalcin, but only those fed cowpea showed decreased bone resorption biomarker, suggesting that cowpea may have the most protective effect on bone in OVX rats.

Authors+Show Affiliations

Department of Food and Nutrition, Hanyang University, Haengdang-dong Seongdong-gu, Seoul 133-791, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21636018

Citation

Lee, Sun Hee, et al. "Consumption of Legumes Improves Certain Bone Markers in Ovariectomized Rats." Nutrition Research (New York, N.Y.), vol. 31, no. 5, 2011, pp. 397-403.
Lee SH, Jin N, Paik DJ, et al. Consumption of legumes improves certain bone markers in ovariectomized rats. Nutr Res. 2011;31(5):397-403.
Lee, S. H., Jin, N., Paik, D. J., Kim, D. Y., Chung, I. M., & Park, Y. (2011). Consumption of legumes improves certain bone markers in ovariectomized rats. Nutrition Research (New York, N.Y.), 31(5), 397-403. https://doi.org/10.1016/j.nutres.2011.04.006
Lee SH, et al. Consumption of Legumes Improves Certain Bone Markers in Ovariectomized Rats. Nutr Res. 2011;31(5):397-403. PubMed PMID: 21636018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of legumes improves certain bone markers in ovariectomized rats. AU - Lee,Sun Hee, AU - Jin,Na, AU - Paik,Doo-Jin, AU - Kim,Deog-Yoon, AU - Chung,Ill-Min, AU - Park,Yongsoon, Y1 - 2011/05/17/ PY - 2011/01/27/received PY - 2011/04/26/revised PY - 2011/04/27/accepted PY - 2011/6/4/entrez PY - 2011/6/4/pubmed PY - 2011/10/13/medline SP - 397 EP - 403 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 31 IS - 5 N2 - Soybeans are known to protect against osteoporosis, but other legumes frequently consumed in Asia have not been studied to learn if they have a similar protective effect. This study investigated the hypothesis that consumption of soybean, mung bean, cowpea, and adzuki bean has beneficial effects on bone biomarkers in ovariectomized rats. Female Sprague-Dawley rats were either sham operated (sham; n = 7) or surgically ovariectomized and then fed a regular AIN-93M diet (OVX; n = 7) or AIN-93M containing soybean (n = 7), mung bean (n = 7), cowpea (n = 7), or adzuki beans (n = 7) for 10 weeks. No bean consumption significantly altered the body, subcutaneous fat, or uterus weight; however, consumption significantly increased the serum calcium/phosphorous ratio and decreased urinary calcium excretion compared with those of the OVX group. Serum concentration of 17β-estradiol was significantly lower in the OVX group compared with that of the sham group and was lowest in the group fed OVX diet containing soybean. Serum osteocalcin concentration was significantly higher in all OVX rats given a diet with beans compared with the same diet without, but urinary deoxypyridinoline excretion was lowest in the group fed OVX diet containing cowpea. There were no significant differences in bone mineral density or bone mineral content of the right femur, tibia, or lumbar spine or in the trabecular bone volume of the tibia among the diet groups. In conclusion, the consumption of soybean, mung bean, cowpea, and adzuki bean in OVX rats improved osteocalcin, but only those fed cowpea showed decreased bone resorption biomarker, suggesting that cowpea may have the most protective effect on bone in OVX rats. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/21636018/Consumption_of_legumes_improves_certain_bone_markers_in_ovariectomized_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(11)00088-1 DB - PRIME DP - Unbound Medicine ER -