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Diagnosis of dengue fever in North West Italy in travelers from endemic areas: a retrospective study.
J Clin Virol. 2011 Aug; 51(4):259-63.JC

Abstract

BACKGROUND

Domestic outbreaks of Dengue (DENV) fever from imported cases have to be considered a possible risk in non-endemic countries where Dengue vectors are present, such as in Italy.

OBJECTIVE

To review imported acute/recent DENV infections in a one-year survey in a North West Italy region where the presence of Aedes albopictus is documented.

STUDY DESIGN

We retrospectively reviewed laboratory and clinical records of Italian febrile travelers from Dengue endemic areas referring to the local reference Centre for Infectious Disease, covering a population of about 4 million people.

RESULTS

Acute/recent DENV infection was identified in 15 out of 91 travelers from endemic areas (16.5%) including 12 primary and 3 secondary infections; in 6 patients the virus was detectable in blood according to molecular real-time Polymerase Chain Reaction-based assays: in 9 patients the diagnosis of DENV infection was accomplished by the combination of specific IgM reactivity, high IgG titers, IgG seroconversion from negative to positive and increasing (four-fold) IgG titers in paired serum samples. Two cases of DENV infections were imported from South Egypt in patients travelling together, confirming the importance of returning travelers as sentinels of a rapidly changing epidemiology in specific geographic areas.

CONCLUSIONS

Our findings outline the high rate of imported Dengue infection in North West Italy and emphasize the need for a continued Dengue surveillance in non-endemic countries as well as a careful evaluation and follow-up of febrile patients returning from Dengue endemic countries.

Authors+Show Affiliations

Microbiology and Virology Laboratory, Amedeo di Savoia Hospital, Corso Svizzera 164, 10149 Torino, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21636317

Citation

Burdino, Elisa, et al. "Diagnosis of Dengue Fever in North West Italy in Travelers From Endemic Areas: a Retrospective Study." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 51, no. 4, 2011, pp. 259-63.
Burdino E, Milia MG, Sergi G, et al. Diagnosis of dengue fever in North West Italy in travelers from endemic areas: a retrospective study. J Clin Virol. 2011;51(4):259-63.
Burdino, E., Milia, M. G., Sergi, G., Gregori, G., Allice, T., Cazzato, M. L., Lucchini, A., Lipani, F., Calleri, G., Orofino, G., Di Perri, G., & Ghisetti, V. (2011). Diagnosis of dengue fever in North West Italy in travelers from endemic areas: a retrospective study. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 51(4), 259-63. https://doi.org/10.1016/j.jcv.2011.05.011
Burdino E, et al. Diagnosis of Dengue Fever in North West Italy in Travelers From Endemic Areas: a Retrospective Study. J Clin Virol. 2011;51(4):259-63. PubMed PMID: 21636317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of dengue fever in North West Italy in travelers from endemic areas: a retrospective study. AU - Burdino,Elisa, AU - Milia,Maria Grazia, AU - Sergi,Giuseppina, AU - Gregori,Gabriella, AU - Allice,Tiziano, AU - Cazzato,Maria Lucia, AU - Lucchini,Anna, AU - Lipani,Filippo, AU - Calleri,Guido, AU - Orofino,Giancarlo, AU - Di Perri,Giovanni, AU - Ghisetti,Valeria, Y1 - 2011/06/01/ PY - 2011/01/12/received PY - 2011/04/09/revised PY - 2011/05/07/accepted PY - 2011/6/4/entrez PY - 2011/6/4/pubmed PY - 2011/10/28/medline SP - 259 EP - 63 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 51 IS - 4 N2 - BACKGROUND: Domestic outbreaks of Dengue (DENV) fever from imported cases have to be considered a possible risk in non-endemic countries where Dengue vectors are present, such as in Italy. OBJECTIVE: To review imported acute/recent DENV infections in a one-year survey in a North West Italy region where the presence of Aedes albopictus is documented. STUDY DESIGN: We retrospectively reviewed laboratory and clinical records of Italian febrile travelers from Dengue endemic areas referring to the local reference Centre for Infectious Disease, covering a population of about 4 million people. RESULTS: Acute/recent DENV infection was identified in 15 out of 91 travelers from endemic areas (16.5%) including 12 primary and 3 secondary infections; in 6 patients the virus was detectable in blood according to molecular real-time Polymerase Chain Reaction-based assays: in 9 patients the diagnosis of DENV infection was accomplished by the combination of specific IgM reactivity, high IgG titers, IgG seroconversion from negative to positive and increasing (four-fold) IgG titers in paired serum samples. Two cases of DENV infections were imported from South Egypt in patients travelling together, confirming the importance of returning travelers as sentinels of a rapidly changing epidemiology in specific geographic areas. CONCLUSIONS: Our findings outline the high rate of imported Dengue infection in North West Italy and emphasize the need for a continued Dengue surveillance in non-endemic countries as well as a careful evaluation and follow-up of febrile patients returning from Dengue endemic countries. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/21636317/Diagnosis_of_dengue_fever_in_North_West_Italy_in_travelers_from_endemic_areas:_a_retrospective_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(11)00183-1 DB - PRIME DP - Unbound Medicine ER -