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Clinical outcomes using accelerated partial breast irradiation in patients with invasive lobular carcinoma.
Int J Radiat Oncol Biol Phys. 2011 Nov 15; 81(4):e547-51.IJ

Abstract

PURPOSE

We compared clinical outcomes of women diagnosed with either invasive lobular carcinoma (ILC) or invasive ductal carcinoma (IDC) treated with accelerated partial breast irradiation (APBI).

METHODS AND MATERIALS

A total of 16 patients with ILC received APBI as part of their breast-conservation therapy (BCT) and were compared with 410 patients with IDC that received APBI as part of their BCT. Clinical, pathologic, and treatment related variables were analyzed including age, tumor size, hormone receptor status, surgical margins, lymph node status, adjuvant hormonal therapy, adjuvant chemotherapy, and APBI modality. Clinical outcomes including local recurrence (LR), regional recurrence (RR), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS) were analyzed.

RESULTS

Median follow-up was 3.8 years for the ILC patients and 6.0 years for the IDC patients. ILC patients were more likely to have positive margins (20.0% vs. 3.9%, p = 0.006), larger tumors (14.1 mm vs. 10.9 mm, p = 0.03) and less likely to be node positive (0% vs. 9.5%, p < 0.001) when compared with patients diagnosed with IDC. The 5-year rate of LR was 0% for the ILC cohort and 2.5% for the IDC cohort (p = 0.59). No differences were seen in the rates of RR (0% vs. 0.7%, p = 0.80), distant metastases (0% vs. 3.5%, p = 0.54), DFS (100% vs. 94%, p = 0.43), CSS (100% vs. 97%, p = 0.59), or OS (92% vs. 89%, p = 0.88) between the ILC and IDC patients, respectively. Additionally, when node-positive patients were excluded from the IDC cohort, no differences in the rates of LR (0% vs. 2.2%, p = 0.62), RR (0% vs. 0%), DFS (100% vs. 95%, p = 0.46), CSS (100% vs. 98%, p = 0.63), or OS (92% vs. 89%, p = 0.91) were noted between the ILC and IDC patients.

CONCLUSION

Women with ILC had excellent clinical outcomes after APBI. No difference in local control was seen between patients with invasive lobular versus invasive ductal histology.

Authors+Show Affiliations

Department of Radiation Oncology, Beaumont Cancer Institute, Oakland University William Beaumont School of Medicine, Royal Oak, MI 48073, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21640491

Citation

Shah, Chirag, et al. "Clinical Outcomes Using Accelerated Partial Breast Irradiation in Patients With Invasive Lobular Carcinoma." International Journal of Radiation Oncology, Biology, Physics, vol. 81, no. 4, 2011, pp. e547-51.
Shah C, Wilkinson JB, Shaitelman S, et al. Clinical outcomes using accelerated partial breast irradiation in patients with invasive lobular carcinoma. Int J Radiat Oncol Biol Phys. 2011;81(4):e547-51.
Shah, C., Wilkinson, J. B., Shaitelman, S., Grills, I., Wallace, M., Mitchell, C., & Vicini, F. (2011). Clinical outcomes using accelerated partial breast irradiation in patients with invasive lobular carcinoma. International Journal of Radiation Oncology, Biology, Physics, 81(4), e547-51. https://doi.org/10.1016/j.ijrobp.2011.04.050
Shah C, et al. Clinical Outcomes Using Accelerated Partial Breast Irradiation in Patients With Invasive Lobular Carcinoma. Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e547-51. PubMed PMID: 21640491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical outcomes using accelerated partial breast irradiation in patients with invasive lobular carcinoma. AU - Shah,Chirag, AU - Wilkinson,J Ben, AU - Shaitelman,Simona, AU - Grills,Inga, AU - Wallace,Michelle, AU - Mitchell,Christina, AU - Vicini,Frank, Y1 - 2011/06/02/ PY - 2011/02/21/received PY - 2011/04/19/revised PY - 2011/04/19/accepted PY - 2011/6/7/entrez PY - 2011/6/7/pubmed PY - 2012/1/10/medline SP - e547 EP - 51 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 81 IS - 4 N2 - PURPOSE: We compared clinical outcomes of women diagnosed with either invasive lobular carcinoma (ILC) or invasive ductal carcinoma (IDC) treated with accelerated partial breast irradiation (APBI). METHODS AND MATERIALS: A total of 16 patients with ILC received APBI as part of their breast-conservation therapy (BCT) and were compared with 410 patients with IDC that received APBI as part of their BCT. Clinical, pathologic, and treatment related variables were analyzed including age, tumor size, hormone receptor status, surgical margins, lymph node status, adjuvant hormonal therapy, adjuvant chemotherapy, and APBI modality. Clinical outcomes including local recurrence (LR), regional recurrence (RR), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS) were analyzed. RESULTS: Median follow-up was 3.8 years for the ILC patients and 6.0 years for the IDC patients. ILC patients were more likely to have positive margins (20.0% vs. 3.9%, p = 0.006), larger tumors (14.1 mm vs. 10.9 mm, p = 0.03) and less likely to be node positive (0% vs. 9.5%, p < 0.001) when compared with patients diagnosed with IDC. The 5-year rate of LR was 0% for the ILC cohort and 2.5% for the IDC cohort (p = 0.59). No differences were seen in the rates of RR (0% vs. 0.7%, p = 0.80), distant metastases (0% vs. 3.5%, p = 0.54), DFS (100% vs. 94%, p = 0.43), CSS (100% vs. 97%, p = 0.59), or OS (92% vs. 89%, p = 0.88) between the ILC and IDC patients, respectively. Additionally, when node-positive patients were excluded from the IDC cohort, no differences in the rates of LR (0% vs. 2.2%, p = 0.62), RR (0% vs. 0%), DFS (100% vs. 95%, p = 0.46), CSS (100% vs. 98%, p = 0.63), or OS (92% vs. 89%, p = 0.91) were noted between the ILC and IDC patients. CONCLUSION: Women with ILC had excellent clinical outcomes after APBI. No difference in local control was seen between patients with invasive lobular versus invasive ductal histology. SN - 1879-355X UR - https://www.unboundmedicine.com/medline/citation/21640491/Clinical_outcomes_using_accelerated_partial_breast_irradiation_in_patients_with_invasive_lobular_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(11)00571-2 DB - PRIME DP - Unbound Medicine ER -