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Effects of synthetic cannabinoids on electroencephalogram power spectra in rats.

Abstract

Several synthetic cannabinoids have recently been distributed as psychoactive adulterants in many herbal products on the illegal drug market around the world. However, there is little information on pharmacology and toxicology of such compounds. Although Δ(9)-tetrahydrocannabinol (Δ(9)-THC), a psychoactive cannabinoid of marijuana, was reported to affect electroencephalograms (EEG) of rats, the effects of synthetic cannabinoids are unknown. We examined the pharmacological activities of three synthetic cannabinoids; cannabicyclohexanol (CCH), CP-47,497 and JWH-018; by analyzing EEG power spectra and locomotor activity after intraperitoneal administration to rats and compared them with those of Δ(9)-THC. The three compounds significantly increased the EEG power in the frequency range of 5.0-6.0 Hz for the first 3h, while Δ(9)-THC decreased the power spectra in the wide range of 7.0-20.0 Hz during the first hour. These results indicate that the effect of the three compounds on EEG is different from that of Δ(9)-THC. Additionally, CCH, CP-47,497 and JWH-018 significantly decreased the locomotor activity for 11.5h, 11h and 4.5h, respectively, after administration which was longer than that of Δ(9)-THC (3.5h). Furthermore, all three compounds significantly reduced the total amounts of locomotor activity during a 3-h, 6-h and 12-h period after injection, whereas no statistical difference was observed for the Δ(9)-THC injection. Among the three compounds, CCH and CP-47,497 exerted a longer duration of the change in the EEG power spectra and suppression of the locomotor activity than JWH-018.

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  • Authors+Show Affiliations

    ,

    National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. nuchiyama@nihs.go.jp

    , , , ,

    Source

    Forensic science international 215:1-3 2012 Feb 10 pg 179-83

    MeSH

    Animals
    Cannabinoids
    Cyclohexanols
    Electroencephalography
    Forensic Toxicology
    Indoles
    Injections, Intraperitoneal
    Locomotion
    Male
    Naphthalenes
    Phenols
    Rats
    Rats, Sprague-Dawley
    Street Drugs

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21640532

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of synthetic cannabinoids on electroencephalogram power spectra in rats. AU - Uchiyama,Nahoko, AU - Kikura-Hanajiri,Ruri, AU - Matsumoto,Naomi, AU - Huang,Zhi-Li, AU - Goda,Yukihiro, AU - Urade,Yoshihiro, Y1 - 2011/06/02/ PY - 2010/11/05/received PY - 2011/04/22/revised PY - 2011/05/05/accepted PY - 2011/6/7/entrez PY - 2011/6/7/pubmed PY - 2012/6/5/medline SP - 179 EP - 83 JF - Forensic science international JO - Forensic Sci. Int. VL - 215 IS - 1-3 N2 - Several synthetic cannabinoids have recently been distributed as psychoactive adulterants in many herbal products on the illegal drug market around the world. However, there is little information on pharmacology and toxicology of such compounds. Although Δ(9)-tetrahydrocannabinol (Δ(9)-THC), a psychoactive cannabinoid of marijuana, was reported to affect electroencephalograms (EEG) of rats, the effects of synthetic cannabinoids are unknown. We examined the pharmacological activities of three synthetic cannabinoids; cannabicyclohexanol (CCH), CP-47,497 and JWH-018; by analyzing EEG power spectra and locomotor activity after intraperitoneal administration to rats and compared them with those of Δ(9)-THC. The three compounds significantly increased the EEG power in the frequency range of 5.0-6.0 Hz for the first 3h, while Δ(9)-THC decreased the power spectra in the wide range of 7.0-20.0 Hz during the first hour. These results indicate that the effect of the three compounds on EEG is different from that of Δ(9)-THC. Additionally, CCH, CP-47,497 and JWH-018 significantly decreased the locomotor activity for 11.5h, 11h and 4.5h, respectively, after administration which was longer than that of Δ(9)-THC (3.5h). Furthermore, all three compounds significantly reduced the total amounts of locomotor activity during a 3-h, 6-h and 12-h period after injection, whereas no statistical difference was observed for the Δ(9)-THC injection. Among the three compounds, CCH and CP-47,497 exerted a longer duration of the change in the EEG power spectra and suppression of the locomotor activity than JWH-018. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/21640532/abstract/Effects_of_synthetic_cannabinoids_on_electroencephalogram_power_spectra_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(11)00220-9 DB - PRIME DP - Unbound Medicine ER -